Four New Clerodane Diterpenes from the Leaves ofCasearia guianensisWhich Inhibit the Interaction of Leukocyte Function Antigen 1 with Intercellular Adhesion Molecule 1

Abstract

Four new clerodane diterpenes, casearinols A and B (1 and 2) and casearinones A and B (3 and 4), were isolated from the leaves of Casearia guianensis. These immunomodulatory compounds have been structurally elucidated primarily on the basis of 2D NMR analysis and spectral data comparison with known compounds. These compounds inhibited the binding of T-cell leukocyte function antigen 1 to intercellular adhesion molecule 1.

New clerodane diterpenoids from Laetia procera (Poepp.) Eichler (Flacourtiaceae), with antiplasmodial and antileishmanial activities

“…12,13 Recently, antiplasmodial activity and a moderate activity against Mycobacterium tuberculosis have been reported. 3 We believe that the present work is the first report of the antileishmanial activity of such compounds.…”

Two New Cytotoxic Clerodane Diterpenoids from Casearia membranacea

“…[1][2][3][4][5] Casearia membranacea HANCE (Flacourtiaceae) is the only species that belongs to the genus Casearia in Taiwan. 6) During the course of searching for novel antitumor agents from the terrestrial plants in Taiwan,[7][8][9] an ethanolic extract of the leaves and twigs of C. membranacea collected in Ken-ting showed significant cytotoxicity against the human prostate tumor cells (PC-3). To explore the origin of biological activity, bioassay-guided fractionation of the extract of the leaves and twigs of this species has resulted in the isolation of two new clerodane diterpenes, designated as caseamenbrols A (1) and B (2), together with the known casearlucin A (3).…”

Expression of cytokines and respiratory burst activity of milk cells in response to Azadirachta indica during bovine mastitis

“…In the present study intramammary infusion of neem extract significantly (P<0.05) reduced the SCC, milk neutrophil % and TBC on day 7, reduction of SCC, milk neutrophil % and TBC reflects the anti-inflammatory and antimicrobial activities of the herb. The phytochemical analysis of the extract revealed presence of triterpene, carbohydrate and phenol, it has been recorded that triterpene possesses anti inflammatory and antimicrobial effects (Hunter et al 1997;Kaur et al 2004;Siddique et al 1992). Similarly, Williamson Biswa and colleagues (2001) reported that the neem extract exerts its bactericidal action by inhibiting cell membrane synthesis against pathogenic microorganisms.…”