New clerodane diterpenoids from Laetia procera (Poepp.) Eichler (Flacourtiaceae), with antiplasmodial and antileishmanial activities

Jullian, Valérie; Bonduelle, Colin; Valentin, Alexis; Acebey, Lucia; Duigou, Anne-Gaëlle; Prévost, Marie-Françoise; Sauvain, Michel

doi:10.1016/j.bmcl.2005.07.090

Cited by 39 publications

(27 citation statements)

References 22 publications

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“…The unceasingly crescent interest of terpenes is due to their high antimalarial activities. The IC 50 values recorded for many of them are around 0.1 to 3.5µg/ml (Kalauni et al, 2006;Suksarman et al, 2006;Chukwejeku et al, 2005;Jullian et al, 2005;Ma et al, 2005). TCA1 TCA2 TCA3 TCA4 TOG1 TOG2 TOG3 TOG4 TOG5 TOG6 TOG7 Tchoumbougang et al, 2005) are known to possess many biological activities (Lahlou et al, 2004;Interaminense et al, 2005;Usip et al, 2006).…”

Section: Resultsmentioning

confidence: 98%

In vitro Antimalarial Activity of 11 Terpenes Isolated from Ocimum gratissimum and Cassia alata Leaves. Screening of Their Binding Affinity with Haemin

Kayembe¹,

Taba²,

Ntumba³

et al. 2012

JPS

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Eleven terpenes extracted from Cassia alata and Ocimum gratissimum leaves were screened for in vitro antimalarial activity against Plasmodium falciparum and for their binding affinity with haemin in ethylene Glycol-water 3:7 solvent. Nine terpenes have promising antimalarial activity with IC 50 values below 1µg/ml; two terpenes showed a good activity with IC 50 values below 4µg/ml. All the terpenes bind strongly with haemin as shown by variation of absorbance of the haemin at λ 600nm in UV-Visible spectrum.

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Section: Resultsmentioning

confidence: 98%

In vitro Antimalarial Activity of 11 Terpenes Isolated from Ocimum gratissimum and Cassia alata Leaves. Screening of Their Binding Affinity with Haemin

Kayembe¹,

Taba²,

Ntumba³

et al. 2012

JPS

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“…28 An extract from L. procera revealed the presence of diterpenes, which inhibited breast cancer cell growth. 29 Extract 1151 was obtained from the aerial organs of P. sprucei, a species that has been studied previously. Quassinosides have been isolated from P. sprucei, and several synthetic derivatives were obtained and evaluated against human tumor cells in vitro, exhibiting strong activity against the HL-60 cell line.…”

Section: Discussionmentioning

confidence: 99%

In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity

et al. 2011

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In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity Abstract: Squamous cell carcinoma (SCC) is the most prevalent cancer of the oral cavity and the fifth most prevalent of all malignancies in males. Many researchers have attempted to develop new treatments that will improve the prognosis of SCC patients. Over 20% of the world's biodiversity is located within the Brazilian forests, but little is known about the chemical and/or pharmacological potential of these plants. Certain extracts obtained from Amazon and Atlantic Forest plants have previously been shown to have cytotoxic activity against various cancers. The aim of this study was to screen these extracts for cytotoxic activity against oral SCC cells. The extracts were analyzed for activity against the KB-ADL#12 cell line at various concentrations up to a maximum dose of 100 µg/mL. Comparisons with a control group were performed using one-way ANOVA. Significant cytotoxicity was induced by the extracts obtained from the aerial parts of Picrolemma sprucei (Simaroubaceae), from the leaves and stems of Laetia suaveolens (Salicaceae), from the aerial parts of Abarema auriculata (Fabaceae-Mimosoideae) and from the stem of A. auriculata.

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“…At the end of the treatment, cell viability was evaluated by measuring the mitochondrial enzyme succinate dehydrogenase activity. This test used sodium 3,3-1(1-phenyl-aminocarboxyl)-3-4-tetrazolium + bis-(4-methoxy-6-nitro)] benzene sulfonic acid hydrate] (XTT) as substrate which was converted to a formazan product detected spectrophotometrically at 450 nm (Jullian et al, 2005). Doxorubicin was used as the control drug.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Antiplasmodial activity of New Caledonia and Vanuatu traditional medicines

Hnawia¹,

Hassani

Deharo

et al. 2011

Pharmaceutical Biology

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New clerodane diterpenoids from Laetia procera (Poepp.) Eichler (Flacourtiaceae), with antiplasmodial and antileishmanial activities

Cited by 39 publications

References 22 publications

In vitro Antimalarial Activity of 11 Terpenes Isolated from Ocimum gratissimum and Cassia alata Leaves. Screening of Their Binding Affinity with Haemin

In vitro Antimalarial Activity of 11 Terpenes Isolated from Ocimum gratissimum and Cassia alata Leaves. Screening of Their Binding Affinity with Haemin

In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity

Antiplasmodial activity of New Caledonia and Vanuatu traditional medicines

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