Formulation, Physicochemical Characterization, and In Vitro Study of Chitosan/HPMC Blends-Based Herbal Blended Patches

Abstract

Abstract. The current work prepared chitosan/hydroxypropyl methylcellulose (HPMC) blends and studied the possibility of chitosan/HPMC blended patches for Zingiber cassumunar Roxb. The blended patches without/with crude Z. cassumunar oil were prepared by homogeneously mixing the 3.5% w/v of chitosan solution and 20% w/v of HPMC solution, and glycerine was used as plasticizer. Then, they were poured into Petri dish and produced the blended patches in hot air oven at 70±2°C. The blended patches were tested and evaluated by the physicochemical properties: moisture uptake, swelling ratio, erosion, porosity, Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction, and photographed the surface and cross-section morphology under SEM technique. Herbal blended patches were studied by the in vitro release and skin permeation of active compound D. The blended patches could absorb the moisture and became hydrated patches that occurred during the swelling of blended patches. They were eroded and increased by the number of porous channels to pass through out for active compound D. In addition, the blended patches indicated the compatibility of the blended ingredients and homogeneous smooth and compact. The blended patches made from chitosan/HPMC blends provide a controlled release and skin permeation behavior of compound D. Thus, the blended patches could be suitably used for herbal medicine application.

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

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Floating ability and drug release evaluation of gastroretentive microparticles system containing metronidazole obtained by spray drying

“…Polymers showed two peaks: CS at 10.18 and 19.72° 2θ, HPMC at 9.58 and 19.36° 2θ and EC at 7.96 and 20.04° 2θ. These polymers present crystalline and amorphous phase when pure and in solid state (Suksaeree et al, 2015).…”

Transdermal patches: Design and current approaches to painless drug delivery

“…Macromolecule penetration was enabled in topically applied medication in the third generation. Physicochemical properties, chemical nature, strength, molecular weight, ionization degree, drug partition coefficients, and the hydrophile-lipophile balance (HLB) of polymers are parameters that should be considered in transdermal patch development (17)(18)(19)(20)(21)(22).…”