Transdermal patches: Design and current approaches to painless drug delivery

Hanbali, Othman A. Al; Khan, Haji Muhammad Shoaib; Sarfraz, Muhammad; Arafat, M. Tarik; Ijaz, S.; Hameed, Abdul

doi:10.2478/acph-2019-0016

Cited by 122 publications

(102 citation statements)

References 88 publications

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“…This property can determine about the contact duration of the applied formulation on skin. This test can be evaluated by a number of test methods such as peel force test, adhesive strength test, and tack test (Al Hanbali et al., 2019). In this experiment, the bioadhesive strength of the formulations was quantified by a self-made device (Figure 2; Xiang et al., 2002).…”

Section: Methodsmentioning

confidence: 99%

Eprinomectin nanoemulgel for transdermal delivery against endoparasites and ectoparasites: preparation, in vitro and in vivo evaluation

Mao

Chen

et al. 2019

Drug Delivery

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Nanoemulgels are composed of O/W nanoemulsion and hydrogels and are considered as ideal carriers for the transdermal drug delivery because these have high affinity to load hydrophobic drugs. The stable formulation of eprinomectin (EPR) is very challenging because of it is high hydrophobic nature. In this work, we have prepared EPR loaded nanoemulgel for the treatment of endo-and ectoparasites. The surface morphology of optimized formulations was characterized by scanning electron microscopy. Additionally, skin permeability and irritation tests were conducted for in vitro safety and in vivo skin retention and pearmeation test of EPR nanoemulgel were conducted for efficacy study. Obtained results indicated that the optimized formulation had good shear-thinning behavior, bioadhesiveness properties, and are nanosized droplets with porous internal structure, which are required for topical application. Furthermore, this formulation has showed good skin permeability in comparison to suspension and has no skin irritating property. Overall, the obtained results proved that nanoemulgel is a promising carrier for transdermal drug delivery and EPR nanoemulgel is a promising formulation for the treatment of endo-and ectoparasites.

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Section: Methodsmentioning

confidence: 99%

Eprinomectin nanoemulgel for transdermal delivery against endoparasites and ectoparasites: preparation, in vitro and in vivo evaluation

Mao

Chen

et al. 2019

Drug Delivery

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“…Patch Thickness: Patch thickness is calculated by taking readings at three to five places on the patch with a digital micrometer screw gauge. Mean thickness and standard deviation of such multiple readings are determined to make sure that patch thickness is appropriate 14 .…”

Section: Characterization and Assessment Tools For Transdermal Patch mentioning

confidence: 99%

“…Folding Endurance: When a particular part of the patch is sliced evenly and repeatedly folded at an identical point until it breaks, folding endurance is the number of times the film is folded without breaking 14 .…”

Section: Characterization and Assessment Tools For Transdermal Patch mentioning

confidence: 99%

Untitled

2020

IJPSR

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Transdermal drug delivery system (TDDS) provides an alternate safe way of drug delivery compared to other invasive techniques. Documented advancement in transdermal science provides sustainable delivery of drug molecules, improved bioavailability, the better therapeutic efficacy of embedded drug's and ability to deliver the drug at a constant rate and also reduces the adverse effects associated with oral delivery of drugs. Skin provides a formidable barrier for topical delivery of drugs to overcome its various agents have been used. TDDS have received more attention recently due to their unique features such as improve bioavailability, controlled release of medication and better patient compliance. Transdermal patches, which consist of the drug along with other ingredients provide an effective way to overcome this barrier. The present review mainly focuses on the various advancement of transdermal drug delivery, the various available method for preparation of transdermal patches, characterization and assessment tools for transdermal patch preparation, patents filled, clinical trial performed on transdermal compounds along with drug approved and future applications of transdermal drug delivery system.

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“…Additionally, it is possible to associate different drugs in these easy-to-use devices. These aspects improve bioavailability, as they result in more uniform plasma levels, with a longer duration of action, which will reduce dose frequency [3]. Although transdermal therapy has real benefits for the patient, over the last four decades, the Food and Drug Administration (FDA) has only approved a small number of these products.…”

Section: Introductionmentioning

confidence: 99%

Compatibility Study of Four Binary Combinations of Active Ingredients for Dermal Film Forming Systems

Rusu¹

2020

FARMACIA

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Adapalene (ADA), levofloxacin (LEV), meloxicam (MEL) and miconazole nitrate (MIC) were selected as potential active ingredients for film systems with dermal or transdermal delivery. This study aimed to evaluate the compatibility of four binary mixtures-ADA and LEV (M1), ADA and MIC (M2), LEV and MEL (M3), and LEV and MIC (M4)combinations for new bioadhesive polymeric matrix dermal systems produced by the casting solvent evaporation technique. The Fouriertransform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and molecular modelling (MM) were used to characterise and evaluate the compatibility between the selected active substances. In the FTIR data, M1, M2, and M4 mixtures presented a good compatibility. DSC revealed different chemical interactions as the temperature rose above 160°C, especially for M3 and M4. Through MM technique, interactions were found on the M2 and M3 mixtures. Following the correlation of all obtained results, the best compatibility was found to be on M1 and M4 combinations. Rezumat Adapalenul (ADA), levofloxacina (LEV), meloxicamul (MEL) şi nitratul de miconazol (MIC) au fost selectate ca potenţiale ingrediente active în sistemele de tip film cu eliberare dermică sau transdermică. Scopul acestui studiu este de a evalua compatibilitatea a patru amestecuri binare-ADA şi LEV (M1), ADA şi MIC (M2), LEV şi MEL (M3), şi LEV şi MIC (M4)-combinaţii pentru noi sisteme dermice de tip matriţă polimerică bioadezivă produse prin tehnica de turnare şi evaporare a solventului. Pentru a caracteriza şi evalua compatibilitatea dintre substanţele active selectate au fost utilizate spectroscopia cu transformată Fourier (FTIR), calorimetria cu scanare diferenţială (DSC) şi modelarea moleculară (MM). Din datele FTIR, amestecurile M1, M2 şi M4 au fost compatibilite. DSC a arătat diferite interacţiuni chimice, în special pentru M3 şi M4, la temperaturi mai mari de 160°C. Prin metoda MM au fost semnalate interacţiuni în combinaţiile M2 şi M3. Ca urmare a corelării tuturor rezultatelor obţinute, cea mai bună compatibilitate a fost găsită în combinaţiile M1 şi M4.

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Transdermal patches: Design and current approaches to painless drug delivery

Cited by 122 publications

References 88 publications

Eprinomectin nanoemulgel for transdermal delivery against endoparasites and ectoparasites: preparation, in vitro and in vivo evaluation

Eprinomectin nanoemulgel for transdermal delivery against endoparasites and ectoparasites: preparation, in vitro and in vivo evaluation

Untitled

Compatibility Study of Four Binary Combinations of Active Ingredients for Dermal Film Forming Systems

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