Formulation consideration and characterization of microemulsion drug delivery system for transnasal administration of carbamazepine

Patel, Rashmin B.; Patel, Mrunali R.; Bhatt, Kashyap K.; Patel, Bankim

doi:10.1016/j.bfopcu.2013.07.002

Cited by 68 publications

(85 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spontaneous formation of ME was evaluated by the addition of a known amount of water at once to a known amount of oil, emulsifier and co-emulsifier with controlled stirring. The ease of formation of clear ME was taken as the criteria of spontaneity of microemulsification (Patel et al 2009(Patel et al , 2011b(Patel et al , 2013a.…”

Section: Construction Of Phase Diagramsmentioning

confidence: 99%

“…The electric conductivity of ME was measured using a conductivity meter (EquipTronics, EQ-664, Mumbai, India) equipped with an inbuilt magnetic stirrer. The viscosity of ME was measured using a Brookfield Viscometer LVDV-IIIU (Brookfield Engineering LABS, Stoughton, USA) with spindle SC 18 at 100 rpm using an interval of 30 s. A rheological study of the MBG was performed using a viscometer with Helipath stand (Patel et al 2009(Patel et al , 2011b(Patel et al , 2013a.…”

Section: Characterization Of Formulationsmentioning

confidence: 99%

“…Tissues were divided into small pieces and stained with hematoxylin and eosin. The sections were observed under 1009 magnifications and photographed (Patel et al 2009(Patel et al , 2011b(Patel et al , 2013a.…”

Section: Histopathological Investigationmentioning

confidence: 99%

“…Also, literature reveals that IPM acts as a chemical enhancer by disordering the prearranged lipids of the horny layer. To study the influence of oil on ME characteristics and penetration-enhancing ability, IPM was chosen for the preparation of MEcontaining ITTN (Patel et al 2009(Patel et al , 2011b(Patel et al , 2013aSubramanian et al 2005).…”

Section: Development and Evaluation Of Microemulsionmentioning

confidence: 99%

“…In comparison, the novel drug delivery systems of recently available anti-acne formulations have potential to reduce the adverse effects without reducing the efficacy. Microemulsion (ME) offers a powerful way for drug delivery as colloidal drug carrier, due to its versatility and favorable advantages (Bachhav and Patravale 2009;Djordjevic 2004;Patel et al 2009Patel et al , 2011bPatel et al , 2013a. The application of ME systems to skin distributes the anti-acne agent(s) steadily and reduce irritation.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Novel isotretinoin microemulsion-based gel for targeted topical therapy of acne: formulation consideration, skin retention and skin irritation studies

Patel¹,

Patel²,

Parikh³

et al. 2015

Appl Nanosci

Self Cite

View full text Add to dashboard Cite

Isotretinoin was formulated in novel microemulsion-based gel formulation with the aim of improving its solubility, skin tolerability, therapeutic efficacy, skin-targeting efficiency and patient compliance. Microemulsion was formulated by the spontaneous microemulsification method using 8 % isopropyl myristate, 24 % Labrasol, 8 % plurol oleique and 60 % water as an external phase. All plain and isotretinoin-loaded microemulsions were clear and showed physicochemical parameters for the desired topical delivery and stability. The permeation profiles of isotretinoin through rat skin from selected microemulsion formulation followed zero-order kinetics. Microemulsion-based gel was prepared by incorporating Carbopol Ò 971 in optimized microemulsion formulation having suitable skin permeation rate and skin uptake. Microemulsion-based gel showed desired physicochemical parameters and demonstrated advantage over marketed formulation in improving the skin tolerability of isotretinoin, indicating its potential in improving topical delivery of isotretinoin. The developed microemulsionbased gel may be a potential drug delivery vehicle for targeted topical delivery of isotretinoin in the treatment of acne.

show abstract

Section: Construction Of Phase Diagramsmentioning

confidence: 99%

Section: Characterization Of Formulationsmentioning

confidence: 99%

Section: Histopathological Investigationmentioning

confidence: 99%

Section: Development and Evaluation Of Microemulsionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Novel isotretinoin microemulsion-based gel for targeted topical therapy of acne: formulation consideration, skin retention and skin irritation studies

Patel¹,

Patel²,

Parikh³

et al. 2015

Appl Nanosci

Self Cite

View full text Add to dashboard Cite

show abstract

Microemulsion and bovine serum albumin nanoparticles as a novel hybrid nanocarrier system for efficient multifunctional drug delivery

Gharbavi

Danafar

Sharafi

2020

J Biomedical Materials Res

View full text Add to dashboard Cite

The present study aims to: (a) design the versatile microemulsions (MEs) system for drug delivery; (b) use the bovine serum albumin nanoparticles for MEs system development; (c) characterize the physicochemical properties, cytotoxicity, and biocompatibility of the modified MEs (MMEs) system; (d) load of paclitaxel (PTX) and folate conjugate of MEs system; and (e) assess the potential of anticancer activity of MEs system. The physicochemical possessions, in vitro and in vivo cytotoxicity, and stability of MMEs system were characterized. The results of our study show that the MEs system was stable, having narrow particle size distribution, nontoxic, biocompatible, and not active for leukocyte proliferation. So it can be concluded that the MMEs system as a promising candidate for a targeted multifunctional drug delivery system (PTX and folate) that is called a smart MEs system.

show abstract

Development of Nutraceutical Emulsions as Risperidone Delivery Systems: Characterization and Toxicological Studies

Igartúa

Calienni

Feas

et al. 2015

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Formulation consideration and characterization of microemulsion drug delivery system for transnasal administration of carbamazepine

Cited by 68 publications

References 22 publications

Novel isotretinoin microemulsion-based gel for targeted topical therapy of acne: formulation consideration, skin retention and skin irritation studies

Novel isotretinoin microemulsion-based gel for targeted topical therapy of acne: formulation consideration, skin retention and skin irritation studies

Microemulsion and bovine serum albumin nanoparticles as a novel hybrid nanocarrier system for efficient multifunctional drug delivery

Development of Nutraceutical Emulsions as Risperidone Delivery Systems: Characterization and Toxicological Studies

Contact Info

Product

Resources

About