Microemulsion and bovine serum albumin nanoparticles as a novel hybrid nanocarrier system for efficient multifunctional drug delivery

Gharbavi, Mahmoud; Danafar, Hossein; Sharafi, Ali

doi:10.1002/jbm.a.36935

Cited by 29 publications

(19 citation statements)

References 50 publications

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“…The in vivo distribution of HNPs in mice was investigated using a near-infrared fluorescent dye (DiD), and the HNPs showed significantly higher lung accumulation at 1, 2, and 4 h postinjection than that of DiD-loaded NPs and DiD solution. Gharbavi et al101 designed a versatile and smart microemulsion system for paclitaxel delivery, using folate conjugated-BSA NPs for its development. Microemulsions are typically made by four components: the surfactant, cosurfactant, oil, and water phase.…”

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confidence: 99%

The Uniqueness of Albumin as a Carrier in Nanodrug Delivery

et al. 2021

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Albumin is an appealing carrier in nanomedicine because of its unique features. First, it is the most abundant protein in plasma, endowing high biocompatibility, biodegradability, nonimmunogenicity, and safety for its clinical application. Second, albumin chemical structure and conformation allows interaction with many different drugs, potentially protecting them from elimination and metabolism in vivo, thus improving their pharmacokinetic properties. Finally, albumin can interact with receptors overexpressed in many diseased tissues and cells, providing a unique feature for active targeting of the disease site without the addition of specific ligands to the nanocarrier. For this reason, albumin, characterized by an extended serum half-life of around 19 days, has the potential of promoting half-life extension and targeted delivery of drugs. Therefore, this article focuses on the importance of albumin as a nanodrug delivery carrier for hydrophobic drugs, taking advantage of the passive as well as active targeting potential of this nanocarrier. Particular attention is paid to the breakthrough NAB-Technology, with emphasis on the advantages of Nab-Paclitaxel (Abraxane), compared to the solventbased formulations of Paclitaxel, i.e., CrEL-paclitaxel (Taxol) in a clinical setting. Finally, the role of albumin in carrying anticancer compounds is depicted, with a particular focus on the albumin-based formulations that are currently undergoing clinical trials. The article sheds light on the power of an endogenous substance, such as albumin, as a drug delivery system, signifies the importance of the drug vehicle in drug performance in the biological systems, and highlights the possible future trends in the use of this drug delivery system.

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confidence: 99%

The Uniqueness of Albumin as a Carrier in Nanodrug Delivery

et al. 2021

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“…The EC coefficient, RI, and %transmittance of niosomes samples were recorded at 1.32-1.98 m.s/cm, 1.11-1.22, and 37-42%, respectively. The EC coefficient of niosomes was greater than that of niosome-selegiline, which is associated with the presence of selegiline that may decrease the percentage of water in the sample [ 37 ]. The refractive index (RI) of the niosome-selegiline was higher than niosome sample.…”

Section: Resultsmentioning

confidence: 99%

Mitigated Oxidative Stress and Cognitive Impairments in Transient Global Ischemia using Niosomal Selegiline-NBP delivery

Jafari

Gharbavi

Baghdadchi

et al. 2022

Behavioural Neurology

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Stroke is the most common reason for adult disabilities and the second ground for death worldwide. Our previous study revealed that selegiline serves as an alternative candidate in transient hypoxia-ischemia. However, aggressive and restless behavior was observed in stroke-induced rats receiving 4 mg/kg selegiline. In comparison, 1 mg/kg selegiline could induce negligible therapeutic effects on mitochondrial dysfunction and histopathological changes. Therefore, we designed oral noisome-based selegiline attached to 4-(4-nitrobenzyl) pyridine to improve transient global ischemia by attenuating cognitive impairments, oxidative stress, and histopathological injury. The investigation was performed in transient hypoxia-ischemia-induced rats by oral administration of nanoformulation containing selegiline (0.25-1 mg/kg) for 4 weeks (3 times a week). Novel object recognition (NOR) was considered to evaluate their cognitive dysfunction. Oxidative stress parameters and brain histopathological assessments were determined following the scarification of rats. Outstandingly, our data demonstrated slower selegiline release from niosomes relative to free drug, which was also in a controlled manner. Our data confirmed significant improvement in cognitive behavior in the NOR test, an increase in glutathione level and total antioxidant power, a decline in MDA and protein carbonyl level, as well as a decreased number of dead cells in histopathological assessment after being exposed to (0.5-1 mg/kg) selegiline-NBP nanoformulation. These data manifested that the selegiline-NBP nanoformulation (0.5-1 mg/kg) could significantly reduce oxidative damage, cognitive dysfunction, and histopathological damage compared to transient hypoxia-ischemia rats, which is 20 times lower than the therapeutic dose in humans. Therefore, the proposed nanoformulation would be capable as an alternative candidate without side effects in stroke.

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“…For instance, Pápay et al studied the pulmonary delivery of apigenin, a natural polyphenol with antioxidant activity from BSA nanoparticles [30]. Gharbavi et al developed a microemulsion system based on BSA nanoparticles to investigate the release behavior of paclitaxel and folate [31]. In another experiment by de Redín et al, human serum albumin nanoparticles were prepared to explore the ocular delivery of Bevacizumab [32].…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Molecular-Level Release of Coumarin-3-Carboxylic Acid and Warfarin-Derivatives from BSA-Based Hydrogels

2021

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This investigation aimed at developing BSA hydrogels as a controlled release system to study the release behavior of spin-labeled coumarin-3-carboxylic acid (SL-CCS) and warfarin (SL-WFR). The release profiles of these spin-labeled (SL-) pharmaceuticals from BSA hydrogels prepared with different procedures are compared in detail. The mechanical properties of the gels during formation and release were studied via rheology, while a nanoscopic view on the release behavior was achieved by analyzing SL-drugs–BSA interaction using continuous wave electron paramagnetic resonance (CW EPR) spectroscopy. The influence of type of drug, drug concentration, duration of gel formation, and gelation methods on release behavior were characterized by CW EPR spectroscopy, EPR imaging (EPRI), and dynamic light scattering (DLS), which provide information on the interaction of BSA with SL-drugs, the percentage of drug inside the hydrogel and the nature and size of the released structures, respectively. We found that the release rate of SL-CCS and SL-WFR from BSA hydrogels is tunable through drug ratios, hydrogel incubation time and gelation procedures. All of the results indicate that BSA hydrogels can be potentially exploited in controlled drug delivery applications.

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Microemulsion and bovine serum albumin nanoparticles as a novel hybrid nanocarrier system for efficient multifunctional drug delivery

Cited by 29 publications

References 50 publications

The Uniqueness of Albumin as a Carrier in Nanodrug Delivery

The Uniqueness of Albumin as a Carrier in Nanodrug Delivery

Mitigated Oxidative Stress and Cognitive Impairments in Transient Global Ischemia using Niosomal Selegiline-NBP delivery

Molecular-Level Release of Coumarin-3-Carboxylic Acid and Warfarin-Derivatives from BSA-Based Hydrogels

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