Formulation and Physical Stability Test of Griseofulvin Microemulsion Gel

Iradhati, Anindya Hana; Jufri, Mahdi

doi:10.22159/ijap.2017.v9s1.22_27

Cited by 28 publications

(27 citation statements)

References 4 publications

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“…Stability studies were carried out for the formulation of snakehead fish powder, the double emulsion as per ICH guidelines at 40±4 °C. Thermodynamic stability of prepared double emulsion formulation was assessed by stability under centrifugation and Freeze-Thaw cycles [12,17].…”

Section: Stability Studymentioning

confidence: 99%

Formulation Development and Characterization of Snakehead Fish Powder in Oral Double Emulsion

Tungadi

Imran

2018

Int J App Pharm

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Objective: Snakehead fish has been scientifically proven to increase levels of albumin and boost the immune system so that the formulation development is required. The objective of this study was to formulate and characterize snakehead fish powder (SFP) in the form of the oral double emulsion.Methods: The manufacture of snakehead fish powder used the conventional method with dry heating at 50 °C. Characterization of SFP utilized proximate analysis method per 3 g of SFP. The double emulsion preparation was carried out by mixing 30% of the primary emulsion (w/o) into 70% of the secondary emulsion (w) to form the w/o/w emulsion. This preparation was prepared in 4 formulas having variations in Tween 80 concentrations at the secondary emulsions of 0.7%, 3.5%, 7.0% and 10.5% w/v, respectively using the spontaneous emulsification method. After that, all formulations were doing some tests, i.e. organoleptic test, pH, viscosity, flow types, globular diameter test and stability tests.Results: The results of proximate analysis every 3 g of SFP have obtained the contents of protein, 16.89%, lipid 24.52%, water 1.73% and ash 1.05%. Based on the optimization of the formula, the preparation of F4 with the content of Tween 80 at 10.5% secondary emulsion is the best formula due to slow phase separation, pH 7, unchanged organoleptic properties, large internal and external globular diameter (6.35 μm and 8.9 μm), as well as having a high viscosity value (1569.84 p) which correspond to pseudo plastic flow.Conclusion: The novelty of SFP can be developed as double emulsion orally based on the results of characterization and evaluation of double emulsion.

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Section: Stability Studymentioning

confidence: 99%

Formulation Development and Characterization of Snakehead Fish Powder in Oral Double Emulsion

Tungadi

Imran

2018

Int J App Pharm

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“…The physical appearance of ZOL gel emulsion during the storage at 25°C showed that the formulation was stable and homogenous till day 28. The consistency and color of the gel emulsion were smooth and did not exhibit phase separation before or after the addition of the gelling agent, showing that the gel emulsion was stable [21]. Its color, taste, and odor were also acceptable.…”

Section: Discussionmentioning

confidence: 98%

“…Owen et al reported that an increase in storage temperature also increases the apparent viscosity [25]. In addition, Iradhati and Juhfri noted that globule flocculation could increase the viscosity during the preparation of ZOL gel emulsion [21]. The fluctuation in the viscosity values on day 14 at 40°C storage and day 14 at 25°C storage might be caused by syneresis, the discharge of the entangled fluid in the gel emulsion to the surface [27].…”

Section: Discussionmentioning

confidence: 99%

Stability of Zoledronate Gel Emulsion in Virgin Coconut Oil

Gayatri

Krisnawati²,

Sahlan³

et al. 2019

Int J App Pharm

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Objective: This study aimed to analyze the physical stability and drug content of zoledronate (ZOL) gel emulsion in virgin coconut oil (VCO) as a newpharmaceutical product at 25°C as room temperature and 40°C as an accelerated temperature for a stability physics test.Methods: The ZOL gel emulsion comprises the following ingredients: 0.16% ZOL powder, 2% carboxymethyl cellulose, 5% VCO, 0.44% sodiumbenzoate, and 0.009% antioxidant butylated hydroxytoluene, and distilled water. Samples of this gel emulsion were stored for 1 month at 25°C and40°C, and the parameters used for stability tests were pH, viscosity, spreadability, and adhesive strength. The drug content was also evaluated with aspectrophotometer. The ZOL gel emulsion was evaluated against these metrics on days 1, 7, 14, and 28.Results: The results showed that ZOL pH, viscosity, spreadability, adhesive strength, and drug content gel emulsion were clinically stable over 28 daysof storage at 25°C, whereas it was not stable when stored at 40°C for the same duration. pH value of ZOL gel emulsion significantly decreased at 28 days(p<0.05). Also for viscosity, adhesive strength, and drug content of ZOL gel emulsion showed statistically significant (p<0.05), except for spreadabilityvalue (p>0.05). The spreadability value between ZOL gel emulsion that stored at 25°C and at 40°C showed no significant result at 7 and 14 days (p>0.05).Conclusion: ZOL gel emulsion was stable at 25°C when stored for 28 days, suggesting that this is a suitable storage temperature at which its physicalstability and drug content can be maintained.

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“…The viscosity values at each rpm like 5, 10, 20, 50, 100 were noted. For the same gel sample, the experiment was repeated thrice, and the average reading was recorded (Andrews, 2009;Iradhati and Jufri, 2017).…”

Section: Viscositymentioning

confidence: 99%

Formulation and Evaluation of Microemulsion Based in Situ Gel of Acyclovir for Vaginal Delivery

Deshkar

Bokare

Todmal

2020

ijrps

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The purpose of the present study was to formulate and evaluate microemulsion based in situ gel of Acyclovir (ACV) for the vaginal delivery. The solubility of ACV in oils and surfactants and co-surfactant was evaluated to identify the components of the microemulsion. Microemulsion region was determined by using the pseudo-ternary phase diagrams for different formulations. Microemulsion formulation was prepared using Labrafil M1994C as oil phase, Cremophor RH40 as surfactant and Polyethylene glycol 400 and Transcutol P as co-surfactant and water. Microemulsion formulations were evaluated for pH, viscosity, conductivity and stability study. In situ gel of ACV, microemulsion was prepared using thermosensitive polymer, poloxamer.In situ gelwas characterized for viscosity, gelling temperature, the effect of dilution on gelling temperature, gelling ability, and in vitro drug release and release kinetics. The globule size of developed microemulsion was less than 100 nm with PDI in the range 0.307 to 0.641. The optimized microemulsion based in situ gel demonstrated shear thinning behaviour, the gelation temperature with and without dilution was in the range of 30-35ºC, and the drug release was sustained over eight hours. Mucoadhesive properties of microemulsion based in situ gel formulations were determined with a texture analyzer using a goat vaginal tissue, and the results indicated that the presence of microemulsion increased the mucoadhesion significantly. Microemulsion based in situ gel was successfully developed for vaginal delivery of Acyclovir.

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Formulation and Physical Stability Test of Griseofulvin Microemulsion Gel

Cited by 28 publications

References 4 publications

Formulation Development and Characterization of Snakehead Fish Powder in Oral Double Emulsion

Formulation Development and Characterization of Snakehead Fish Powder in Oral Double Emulsion

Stability of Zoledronate Gel Emulsion in Virgin Coconut Oil

Formulation and Evaluation of Microemulsion Based in Situ Gel of Acyclovir for Vaginal Delivery

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