Formulation and physical properties observations of soy lecithin liposome containing 4-n-butylresorcinol

Abstract

ARTICLES YOU MAY BE INTERESTED INHemoglobin level after ingestion of repeated dose of iron shortly after and 2 hours after meal for 12 weeks in second & third trimester pregnant women with iron deficiency anemia AIP Conference Proceedings 1755, 160004 (2016) Abstract.Liposomes are preparations which have many advantages such as high solubility and good stability. The 4-n-butylresorcinol has the effect of hypopigmentation and, similar to resorcinol, is unstable. Liposomes could, therefore, assist the development of 4-n-butylresorcinol in a more appropriate dosage form. The research presented in this article aimed to determine the effect of the concentration of soy lecithin phospholipids to the liposome particle size. Subsequently, the effect of adding 4-n-butylresorcinol as the active compound to the liposomes in the particle size and morphology of the liposomes is also presented. The preparation of liposomes was assisted by sonication, and subsequently, the active compound 4-n-butylrecorcinol was added. Particle size and morphology of liposomes were then characterized as the observed parameters. In this research, there was no evidence that the size of the liposomes was significantly affected by the concentration of phospholipids. Notably, the particle size and morphology of liposomes with 4-n-butylresorcinol as the active substance were not significantly different compared to the liposomes without 4-n-butylresorcinol.

Analytical Method Validation and Determination of Free Drug Content of 4-<i>n</i>-Butylresorcinol in Complex Lipid Nanoparticles Using RP-HPLC Method

“…The polydispersity index during the storage time (0-30 days) met the acceptance criteria for the polydisperse nanoparticle system of < 0.3 [26]. Complex lipid nanoparticles resulting from the heating and sonication method had a particle size similar to the previous study [20]. Morphology of complex lipid nanoparticle from TEM observation was shown in Fig.…”

“…Preparation of complex lipid nanoparticle was prepared by dispersing 8.70 g phospholipid in 100 mL distilled water [19] with 0.1% (w/v) 4-n-butylresorcinol [20]. Phospholipids and water were mixed and blended for 60 sec.…”

Multiple Response Optimization of a HPLC Method for Analyzing Resorcinol and 4-<i>n</i>-Butyl Resorcinol in Lipid Nanoparticles

“…Ikapharmindo Putramas). Lipid nanoparticle was produced in the Faculty of Pharmacy, Sanata Dharma University, Indonesia [43].…”

“…This design was more effective and economical than other three-level designs [38], with fewer experimental runs compared to full factorial or CCD [39]. In addition, BBD was commonly applied in several studies of HPLC method development [40][41][42][43].…”

Transfersome as Topical Drug Delivery: Formulation and Characterization

“…The active substance or drug contained in the supernatant is defined as the amount of drug that is not encapsulated (free drug) (Dwiastuti et al 2016). According to research by Al Shuwaili et al (2016),…”