Formulation and pH-Physical Stability Evaluation of Gel and Cream of Plantago major Leaves Extract

Kartini, Kartini; Winarjo, Babtista Merchyta; Fitriani, Endang Wahyu; Islamie, Ridho

doi:10.24123/mpi.v1i3.330

Cited by 9 publications

(11 citation statements)

References 4 publications

(5 reference statements)

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“…The pH range should not be too acidic or alkaline, because irritation to the skin might be unavoidable. The pH mitigation is probably due to separation of the cream emulsion from its matrix and ionization, resulting in net negative charge and causing the rise in acidity [ 41 , 42 ]. To avoid exceedingly high pH values beyond the skin’s physiological range, a preservative solution was added to the formulations.…”

Section: Resultsmentioning

confidence: 99%

Synergistics of Carboxymethyl Chitosan and Mangosteen Extract as Enhancing Moisturizing, Antioxidant, Antibacterial, and Deodorizing Properties in Emulsion Cream

et al. 2022

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Carboxymethyl chitosan (CMCH) from native chitosan of high molecular weight (H, 310–375 kDa) was synthesized for improving water solubility. The water solubility of high-molecular-weight carboxymethyl chitosan (H-CMCH) was higher than that of native chitosan by 89%. The application of H-CMCH as enhancing the moisturizer in mangosteen extract deodorant cream was evaluated. Different concentrations of H-CMCH (0.5–2.5%) were investigated in physicochemical characteristics of creams, including appearance, phase separation, pH, and viscosity, by an accelerated stability test. The different degrees of skin moisturizing (DM) on pig skin after applying H-CMCH solution, compared with untreated skin, water, and propylene glycol for 15 and 30 min using a Corneometer®, were investigated. The results showed that the 0.5% H-CMCH provided the best DM after applying the solution on pig skin for 30 min. Trans-2-nonenal, as an unsatisfied odor component, was also evaluated against components of the mangosteen extract deodorant cream, which were compared to the standard, epigallocatechin gallate (EGCG). In addition, DPPH and ABTS radical scavenging activity, ferric reducing antioxidant power (FRAP), and antibacterial activities were examined for the mangosteen extract deodorant cream using 0.5% H-CMCH. Results indicated that the mangosteen extract synergized with H-CMCH, which had a good potential as an effective skin moisturizing agent enhancer, deodorizing activity on trans-2-nonenal odor, antioxidant properties, and antibacterial properties.

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Section: Resultsmentioning

confidence: 99%

Synergistics of Carboxymethyl Chitosan and Mangosteen Extract as Enhancing Moisturizing, Antioxidant, Antibacterial, and Deodorizing Properties in Emulsion Cream

et al. 2022

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“…The use of centrifugation methods in viewing emulsion phase separation is very useful for predicting the storage time of preparation [33]. Stokes's law showed that increasing gravity could accelerate separation.…”

Section: Results Of Cream Phase Separation Testingmentioning

confidence: 99%

Formulation and Evaluation of Alpha Arbutin Skin Lightening Cream Using Polyacrylate Base by Cold Process

Mustarichie

Sopyan

2019

Int J App Pharm

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Objective: The objective of this research was to formulate and evaluate alpha arbutin skin lightening cream using polyacrylate base by cold process.Methods: Five formulas of alpha arbutin skin lightening cream were prepared with Polyacrylate Base with different polyacrylate concentrations as a cream base for each formula. The various concentrations of polyacrylate (2, 3, 4, 5, and 6%) was used as a cream base. The resulting preparation was then examined and observed for consistency, color, odor, and stability for 28 d of storage.Results: The phase separation test results stated that the five cream formulas did not experience phase separation in 2500, 3000, and 3750 rpm centrifugations so that it could be concluded that the five cream formulas were stable in storage at room temperature for at least 12 mo. From the physical evaluation of cream preparations, it was found that the cream formula with 6% polyacrylate concentration gave the best stability results. Cream safety testing results stated that the cream did not irritate the skin of the wearer.Conclusion: The results obtained in this research work clearly indicated alpha arbutin cream can be formulated using polyacrylate as a cream base, and in its manufacture, it can be carried out with a cold process.

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“…Apart from viscosity, pH value also plays a crucial role in the properties of the gel. Alkaline formulations with a pH >8 will agglomerate and become too concentrated, affecting the spreadability on human skin, while acidic formulations with pH <5 dilutes the formulation and irritates the skin [81]. The optimum viscosity of Carbopol for good spreadability is typically achieved at a pH range of 6.5-7.5 [82].…”

Section: Hydrogel Formulationsmentioning

confidence: 99%

Hydrophobic Drug Carrier from Polycaprolactone-b-Poly(Ethylene Glycol) Star-Shaped Polymers Hydrogel Blend as Potential for Wound Healing Application

et al. 2023

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Blending hydrogel with an amphiphilic polymer can increase the hydrophobic drug loading and entrapment efficiency of hydrogel-based formulations. In this study, a hydrogel formulation with star-shaped polycaprolactone-b-poly(ethylene glycol) (PCL-b-PEG) as the hydrophobic drug cargo is produced. The 4-arm and 6-arm star-shaped PCL are synthesized with different molecular weights (5000, 10,000, 15,000 g/mol) via ROP and MPEG as the hydrophilic segment is attached via the Steglich esterification. FTIR and 1H-NMR analysis showed the presence of all functional groups for homopolymers and copolymers. Mn for all synthesized polymers is close to the theoretical value while GPC spectra showed a monomodal peak with narrow molecular weight distribution (PDI:1.01–1.25). The thermal degradation temperature and crystalline melting point of synthesized polymers increase with the increase in molecular weight and number of arms. All formulations possess high drug loading and entrapment efficiency (>99%) and increase with increasing molecular weight, number of arms, and amount of polymer in the formulations. All formulations showed a sustained drug release pattern with no initial burst, which follows the Korsmeyer–Peppas kinetic model. The polymer hydrogel formulations showed antibacterial activity against E. coli and S. aureus. The hydrogel containing 4-arm PCL15k-PEG is chosen as the best formulation due to its high drug release, good antimicrobial activity, and morphology.

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Formulation and pH-Physical Stability Evaluation of Gel and Cream of Plantago major Leaves Extract

Abstract: Plantago major has been widely used for wound healing. This activity is supported by empirical as well as preclinical data. The aims of this study were to (1) formulate Plantago major leaves extracts (PMLE) into topical dosage forms i.e. creams and gels and; (2)

Cited by 9 publications

References 4 publications

Synergistics of Carboxymethyl Chitosan and Mangosteen Extract as Enhancing Moisturizing, Antioxidant, Antibacterial, and Deodorizing Properties in Emulsion Cream

Synergistics of Carboxymethyl Chitosan and Mangosteen Extract as Enhancing Moisturizing, Antioxidant, Antibacterial, and Deodorizing Properties in Emulsion Cream

Formulation and Evaluation of Alpha Arbutin Skin Lightening Cream Using Polyacrylate Base by Cold Process

Hydrophobic Drug Carrier from Polycaprolactone-b-Poly(Ethylene Glycol) Star-Shaped Polymers Hydrogel Blend as Potential for Wound Healing Application

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