Formulation and Evaluation of Spray-Dried Esomeprazole Magnesium Microspheres

Jain, Ankit; Teja, M.S. Brahma; Pariyani, L; Balamuralidhara, V.; Gupta, N. Vishal

doi:10.4314/tjpr.v12i3.4

Cited by 7 publications

(9 citation statements)

References 8 publications

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“…A Carr index value of 5-15% is indicative of excellent flow, 12-16% is good flow, and 18-21% is fair flow. [ 26 27 28 ] Thus, it could be evaluated from the values obtained from the compressibility index of insulin-loaded Eudragit ® entrapped microspheres (U 1 = 13.43 ± 1.63; U 2 = 22.23 ± 2.08; and U 3 = 18.91 ± 1.54%) that there were varying flow patterns by the various batches of the microspheres. The results showed inconsistency in the flow behavior of the individual batches with respect to increasing proportions of Eudragit ® RL 100 used in formulating the microspheres.…”

Section: Resultsmentioning

confidence: 99%

“…Four kinetic models including the zero-order, first-order, Higuchi square root, and Hixson-Crowell cube root models were applied to process the release data to find out the equation with the best fit. [ 28 33 ]…”

Section: Methodsmentioning

confidence: 99%

“…They aid in the protection of protein by preventing them from interacting with any substance till the complete degradation of the polymer and hence, reducing the contact with solutions, which degrade the protein. [ 28 ] The choice of microencapsulation technique depends on the attributes of the polymers and the drug, the site of the drug action, and the duration of the therapy. [ 29 30 31 ]…”

Section: Introductionmentioning

confidence: 99%

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Formulation, characterization and evaluation of the effect of polymer concentration on the release behavior of insulin-loaded Eudragit^®-entrapped mucoadhesive microspheres

Kenechukwu

Momoh

2016

Int J Pharma Investig

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Introduction:The aim of this study was to use Eudragit® RL 100 (pH-independent polymer) and magnesium stearate (a hydrophobic droplet stabilizer) in combination to improve the controlled release effect of insulin-loaded Eudragit® entrapped microspheres prepared by the emulsification-coacervation technique.Materials and Methods:Mucoadhesive insulin-loaded microspheres containing magnesium stearate and varying proportions of Eudragit® RL 100 were prepared by the emulsification-coacervation technique and evaluated for thermal properties, physicochemical performance, and in vitro dissolution in acidic and subsequently basic media.Results:Stable, spherical, brownish, discrete, free-flowing and mucoadhesive insulin-loaded microspheres with size range of 14.20 ± 0.30-19.80 ± 0.60 μm and loading efficiency of 74.55 ± 1.05-75.90 ± 1.94% were formed. After 3 h, microspheres prepared with insulin: Eudragit® RL 100 ratios of 1:4, 1:6, and 1:8 released 73.40 ± 1.38, 66.20 ± 1.59, and 71.30 ± 1.27 (%) of insulin, respectively.Conclusion:The physicochemical and physico-technical properties of the microspheres developed in this study demonstrated the effectiveness of the Eudragit® RL entrapped mucoadhesive microspheres (prepared by the emulsification-coacervation technique using varying polymer concentration) as a carrier system for oral insulin delivery.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Formulation, characterization and evaluation of the effect of polymer concentration on the release behavior of insulin-loaded Eudragit^®-entrapped mucoadhesive microspheres

Kenechukwu

Momoh

2016

Int J Pharma Investig

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“…2 mg of Esomeprazole Magnesium was triturated in glass mortar along with 200 mg of potassium bromide [16]. The mixture was compressed in hydraulic KBr pellet press at a pressure of 6000 kg/cm 2 to obtain a transparent pellet [17]. This pellet was analyzed under the FTIR spectrophotometer under a scanning range between 4000 cm -1 -400 cm -1 at a resolution of 4 cm -1 [16].…”

Section: Identification Of Esomeprazole Magnesium By Ftirmentioning

confidence: 99%

Qualitative Portrayal of Esomeprazole Magnesium by Exploring Diverse Analytical and Investigative Approaches

Kanwar

Gautam

2021

JPRI

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Purpose: The present study was intended to qualitatively analyze and drive meaningful statistics for Esomeprazole magnesium; to establish its inherent properties qualitatively & quantitatively. Methods: Esomeprazole magnesium was analyzed using various traditional & modern analytical and investigative tools viz FTIR, HPLC, UV spectroscopy, X-ray diffraction, zetasizer. Results: The absorption maxima were found at 301 nm with UV Spectrophotometric and HPLC analysis. The particle size of the drug was analyzed through Malvern zetasizer employing water as diluent and found to be 11.818 µm. The quantitative solubility of Esomeprazole magnesium was predicted in various solvents at 25 0C and found that it was most soluble in methanol and was least soluble in distilled water. Solubility was also found to be pH-dependent. Solubility increases with an increase in pH. The order of solubility determined was; Methanol (1.214 mg/ml) > Phosphate buffer pH- 7.4 (0.521 mg/ml) > Simulated Intestinal fluid pH-6.8 (0.475 mg/ml) > Phosphate buffer pH- 6.8 (0.466 mg/ml) > Simulated Gastric fluid pH-1.2 (0.147 mg/ml) > 0.1 N HCl (0.131 mg/ml) > Distilled water (0.017 mg/ml). The predicted log P value was found to be 2.39. Conclusion: Esomeprazole magnesium was qualitatively analyzed using various analytical techniques to establish its inherent properties quantitatively. It is an off-white amorphous powder with a characteristic obnoxious odor and slightly bitter taste. The drug was identified through FTIR, using the classification of characteristic peaks of functional groups in the spectrum and also additionally through analytical methods viz HPLC, UV spectroscopy and found the absorption maxima at 301 nm. The linear regression analyses of a standard plot from UV spectrophotometric analysis demonstrate an unswerving relationship in the concentration range of 5-30μg/ml. The log P value indicates that the drug is significantly lipophilic. Various Micromeritic parameters like the Angle of repose, compressibility index, and Hausner's ratio predict the inherent flow properties of Esomeprazole magnesium as Fair (aid not needed). The present study will be an asset in the development of a modified released quick action formulation (Tablet-in-Tablet), to offer quick and protracted relief in gastritis and allied disorders.

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“…There is currently a very limited number of studies in the literature concerning esomeprazole and esomeprazole impregnated into carriers. Some of these carriers include locust bean and xanthan gum polymers applied in a spray drying process [ 23 ], pH-sensitive starch hydrogels [ 24 ], and zinc (Zn) solid dispersion for delayed release [ 25 ]. The target for the release of the esomeprazole is the stomach.…”

Section: Introductionmentioning

confidence: 99%

Influence of the Impregnation Technique on the Release of Esomeprazole from Various Bioaerogels

et al. 2021

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The presented study shows the possibility of using bioaerogels, namely neat alginate, pectin, chitosan aerogels, and alginate and pectin aerogels coated with chitosan, as drug delivery systems for esomeprazole. Two different techniques were used for the impregnation of esomeprazole: Supercritical impregnation, and diffusion via ethanol during the sol-gel synthesis. The prepared samples were characterized by employing N2 adsorption-desorption analysis, TGA/DSC, and FTIR. The achieved loadings were satisfactory for all the tested samples and showed to be dependent on the technique used for impregnation. In all cases, higher loadings were achieved when impregnation via diffusion from ethanol was used. Extensive release studies were performed for all impregnated samples. The in vitro dissolution profiles were found to be dependent on the carrier and impregnation method used. Most importantly, in all cases more controlled and delayed release was achieved with the bioaerogels compared to using pure esomeprazole.

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Formulation and Evaluation of Spray-Dried Esomeprazole Magnesium Microspheres

Cited by 7 publications

References 8 publications

Formulation, characterization and evaluation of the effect of polymer concentration on the release behavior of insulin-loaded Eudragit^®-entrapped mucoadhesive microspheres

Formulation, characterization and evaluation of the effect of polymer concentration on the release behavior of insulin-loaded Eudragit^®-entrapped mucoadhesive microspheres

Qualitative Portrayal of Esomeprazole Magnesium by Exploring Diverse Analytical and Investigative Approaches

Influence of the Impregnation Technique on the Release of Esomeprazole from Various Bioaerogels

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Formulation and Evaluation of Spray-Dried Esomeprazole Magnesium Microspheres

Cited by 7 publications

References 8 publications

Formulation, characterization and evaluation of the effect of polymer concentration on the release behavior of insulin-loaded Eudragit®-entrapped mucoadhesive microspheres

Formulation, characterization and evaluation of the effect of polymer concentration on the release behavior of insulin-loaded Eudragit®-entrapped mucoadhesive microspheres

Qualitative Portrayal of Esomeprazole Magnesium by Exploring Diverse Analytical and Investigative Approaches

Influence of the Impregnation Technique on the Release of Esomeprazole from Various Bioaerogels

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Formulation, characterization and evaluation of the effect of polymer concentration on the release behavior of insulin-loaded Eudragit^®-entrapped mucoadhesive microspheres

Formulation, characterization and evaluation of the effect of polymer concentration on the release behavior of insulin-loaded Eudragit^®-entrapped mucoadhesive microspheres