Formulation and Evaluation of Metformin Hydrochloride Loaded Floating Microspheres

Abstract

Objective: The main objective of this study was to develop and evaluate the eudragit and HPMC coated metformin hydrochloride floating microspheres, in which HPMC helps in floating and eudragit as a coating material for a site-specific drug release in a controlled manner and the active moiety metformin used as anti-hyperglycemic agent.
 Methods: The floating microsphere was prepared by the solvent evaporation method incorporating metformin as a model drug. The prepared floating microsphere were characterized for particle size, %yield, drug loading and entrapment efficiency, compatibility study, %buoyancy, surface morphology and In vitro drug release and release kinetics.
 Results: The result metformin loaded floating microsphere was successfully prepared and the particle size range from 397±23.22 to 595±15.82 µm, the entrapment efficiency range from 83.49±1.33 to 60.02±1.65% and drug loading capacity range from 14.3±0.54 to 13.31±0.47% and %buoyancy range from 85.67±0.58 to 80.67±1.15%. The FT-IR and X-RD analysis confirmed that no any interaction between drug and excipient, and surface morphology confirmed those particles are sphere. The floating microsphere show maximum 96% drug release in pH 0.1N HCL and follow the Korsmeyer peppas model of the super case-2 transport mechanism.
 Conclusion: These results suggest that metformin loaded floating microspheres could be retain in stomach for long time and give site specific drug release in controlled manner.

Formulation and Evaluation of Xanthan Gum Microspheres for the Sustained Release of Metformin Hydrochloride

“…However, very little work has been done on the microencapsulation of MTH using xanthan gum. A single study was conducted in 2016 by Ramalingam Nethaji et al [ 26 ], where sodium alginate and different concentrations of natural mucoadhesive polymers such as xanthan gum and guar gum were used to develop gastroretentive formulations via the ionic gelation technique. In this study, the effect of the xanthan gum/guar gum mixture ratio on the properties of the microparticles obtained and on the release of MTH in the gastric medium (1.2) was evaluated.…”

Enhancement of Therapeutic Window of Metformin Hydrochloride by Fabrication of Microspheres Comprising Polymeric Inculcation With Semi-Synthetic and Synthetic Polymers by Implementation of Box-Behnken Design

“…It was observed from the obtained data that mean particle size of MFH loaded microspheres ranged between 246.01±0.49 µm to 289.13±0.07 µm for all fabricated formulations, whereas in one study executed by Kesharwani S et al, 2020 [31] they had fabricated MFH microspheres incorporating eudragit and HPMC with particle size range 397±23.22 µm to 595±15.82 µm and entrapment efficiency ranged from (83.49±1.33) % to (60.02±1.65) %. On implementation of BBD to the parameter mean particle size yielded superior microspheres with spherical surface, smaller particle size and microsphere size increased on increasing polymer concentration for all the seven formulations.…”

Development of Bilayer Tablets of Losartan Potassium and Metformin Hydrochloride Layer Using Natural Gums as Polymers

“…Optimized IR granules of losartan potassium (L4) + SR granules of metformin hydrochloride were (F2) fed in to separate hoppers of the bilayer tablet compression machine (Cadmach, Ahmedabad). Single compression of SR granules was done followed by the filing of IR granules on SR layer [20]. Finally, compression of IR layer over SR layer resulting in the formation of bilayer tablets.…”