Formulation and Evaluation of Xanthan Gum Microspheres for the Sustained Release of Metformin Hydrochloride

Yahoum, Madiha Melha; Toumi, Selma; Tahraoui, Hichem; Lefnaoui, Sonia; Kebir, Mohammed; Amrane, Abdeltif; Assadi, Aymen Amine; Zhang, Jie; Mouni, Lotfi

doi:10.3390/mi14030609

Cited by 13 publications

(17 citation statements)

References 40 publications

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“…The IR spectra of the tara gum samples showed a broad absorption band at 3393–3442 cm −1 due to the stretching frequency of the OH group [ 63 , 64 ]. The presence of –OH stretching could be attributable to sugars such as galactose and arabinose [ 5 ].…”

Section: Resultsmentioning

confidence: 99%

“…The presence of –OH stretching could be attributable to sugars such as galactose and arabinose [ 5 ]. The absorption band between 2924 and 2926 cm −1 is attributable to the stretching of the CH of the alkyl group [ 37 , 65 ], and those located between 1413 and 1424 cm −1 are due to the bending of the CH of the methyl group [ 64 , 65 ]. Likewise, the absorption bands located between 1633 and 1643 cm −1 are attributable to the asymmetric stretching of the carboxylate ion [ 65 ].…”

Section: Resultsmentioning

confidence: 99%

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Preliminary Assessment of Tara Gum as a Wall Material: Physicochemical, Structural, Thermal, and Rheological Analyses of Different Drying Methods

Moscoso-Moscoso,

Ligarda-Samanez,

Choque-Quispe

et al. 2024

Polymers

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Tara gum, a natural biopolymer extracted from Caesalpinia spinosa seeds, was investigated in this study. Wall materials were produced using spray drying, forced convection, and vacuum oven drying. In addition, a commercial sample obtained through mechanical methods and direct milling was used as a reference. The gums exhibited low moisture content (8.63% to 12.55%), water activity (0.37 to 0.41), bulk density (0.43 to 0.76 g/mL), and hygroscopicity (10.51% to 11.42%). This allows adequate physical and microbiological stability during storage. Polydisperse particles were obtained, ranging in size from 3.46 µm to 139.60 µm. Fourier transform infrared spectroscopy characterisation confirmed the polysaccharide nature of tara gum, primarily composed of galactomannans. Among the drying methods, spray drying produced the gum with the best physicochemical characteristics, including higher lightness, moderate stability, smaller particle size, and high glass transition temperature (141.69 °C). Regarding rheological properties, it demonstrated a non-Newtonian pseudoplastic behaviour that the power law could accurately describe. The apparent viscosity of the aqueous dispersions of the gum decreased with increasing temperature. In summary, the results establish the potential of tara gum as a wall material applicable in the food and pharmaceutical industries.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Preliminary Assessment of Tara Gum as a Wall Material: Physicochemical, Structural, Thermal, and Rheological Analyses of Different Drying Methods

Moscoso-Moscoso,

Ligarda-Samanez,

Choque-Quispe

et al. 2024

Polymers

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show abstract

“…This peak became narrower over time, particularly after the 720 W-6 min, however, the peak intensity increased compared to 960 and 1200 W, despite a reduction in the amount of water. The reduced intensity of this signal in treated XG samples at 960 and 1200 W could possibly be ascribed to OH group substitution (Yahoum et al, 2023). The broadening of this peak and its shift to a lower wavenumber with modification implies a gradual increase in the intermolecular hydrogen bonding between the molecules (Solo- de-Zaldívar et al, 2014).…”

Section: Dynamic Rheological Propertiesmentioning

confidence: 96%

Microwave‐modified xanthan gum: Alterations in steady and dynamic rheological behaviors

Kurt,

Ozturk,

Ozmen

et al. 2024

J Food Process Engineering

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In this study, microwave modification of xanthan gum (XG) powder under various power and time settings was aimed at achieving diversity for different applications requiring different flow behaviors. Microwave treatment for 6 min at various powers showed no noticeable effect on the properties of XG. The apparent viscosity, consistency coefficient and viscoelastic properties (G′–G″) increased as powders were subjected to microwave treatment for up to 8 min and the highest increase was observed in XGs with 720 W application. The increasing power to 1200 W resulted in a decrease in consistency at 8 min. At all levels of power, a prolonged microwave treatment (10 min) resulted in the degradation of the molecules, leading to a decrease in the mentioned rheological properties of XG. The values for intercepts (K′ and K″) began to increase at 960 W‐6 min, with the largest increase occurring at 720 W‐8 min. Fourier transform infrared (FTIR) analysis revealed that the primary structure and repeated units were not negatively impacted by the use of microwave treatment. Therefore, with adjustable modification, microwaves may be employed to produce xanthan gum with a high economic value that is suitable for a variety of applications, while maintaining the gum's color properties.Practical applicationsOur research demonstrated that the use of microwave technology as a non‐thermal physical process to modify xanthan gum powder without dissolving it in water is a highly effective technique. This approach enables the flow characteristics of xanthan gum to be conveniently modified, regardless of its concentration, and increases its economic value by diversifying its techno‐functional properties. The increase in apparent viscosity and viscoelastic properties by increasing the interaction of polymer molecules or the adaptation of xanthan gum to different purposes by polymer degradation can be adjusted depending on the power and time of the microwave.

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“…Furthermore, it was recently reported that xanthan gum has a potential bloodsugar-lowering and stabilizing effect. This last particular property makes xanthan gum an excellent candidate for the administration of active antidiabetic substances [6,7] . Given that natural polymers are safe, biocompatible, and biodegradable, their contribution to the formulation of dosage forms is noteworthy.…”

Section: Introductionmentioning

confidence: 99%

Formulation and in-vitro Evaluation of Vildagliptin Microspheres Using Pectin and Xanthan Gum as Polymers

MANUBOLU,

PEERIGA,

BABA

et al. 2024

Preprint

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Aim The aim of the work is a formulation and in vitro evaluation of the vildagliptin microsphere using pectin and xanthan gum. Objective Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor extensively associated with the therapy of type-2 diabetes mellitus. A controlled release of the drug in the gastrointestinal tract may aid in maintaining the therapeutic range for an extended period. Sodium alginate, pectin, and xanthan gum are commonly used as biopolymers in drug delivery with favourable biocompatibility and biodegradation. Materials and method Sodium alginate-pectin and sodium alginate-xanthan gum beads were developed to deliver vildagliptin. A calcium chloride ion (cacl2) induced ionic gelation technique was employed for synthesizing pH-sensitive beads by varying the ratio of sodium alginate, pectin, and xanthan gum. Results The FTIR investigation verified that drugs and polymers are compatible. The developed beads were evaluated for scanning electron microscopic and DSC study, drug content, swelling ratio, and in-vitro dissolution study. The microscopic images exhibited some are in spherical and semi-spherical shaped beads with cracked and rough surfaces. A pH-dependent swelling was seen, indicating that water intake was restricted in an acidic medium and elevated in an alkaline pH environment. The in-vitro dissolution study demonstrated a controlled release of the drug. optimized formulation Exhibiting diffusion release. Conclusion The study reported the successful development of vildagliptin microspheres by using sodium alginate, pectin, and xanthan beads for controlled delivery of Vildagliptin.

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Formulation and Evaluation of Xanthan Gum Microspheres for the Sustained Release of Metformin Hydrochloride

Cited by 13 publications

References 40 publications

Preliminary Assessment of Tara Gum as a Wall Material: Physicochemical, Structural, Thermal, and Rheological Analyses of Different Drying Methods

Preliminary Assessment of Tara Gum as a Wall Material: Physicochemical, Structural, Thermal, and Rheological Analyses of Different Drying Methods

Microwave‐modified xanthan gum: Alterations in steady and dynamic rheological behaviors

Formulation and in-vitro Evaluation of Vildagliptin Microspheres Using Pectin and Xanthan Gum as Polymers

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