Formulation and evaluation of glipizide tablets utilizing Hibiscus rosasinensis leaves mucilage

Abstract

This research work aims to develop glipizide tablets using Hibiscus rosasinensis leaves mucilage. The mucilage was extracted by using double distilled water and precipitated with ethanol. The precipitated mucilage was dried and grounded into powder. The tablet utilizing the mucilage as excipient was prepared by wet granulation method. The tablets were subjected to various tests. The evaluatory parameters of tablets were found to be within the limits as per United States Pharmacopoeia NF 24/19. FTIR spectrum reveals that there is no incompatibility between the ingredients used. Diabetes was induced in wistar albino rats using streptozotocin and effect of formulation on blood glucose level was determined. It was observed that the formulation could not sustain the release of glipizide. However, the glipizide release was retarded as the amount of mucilage was increased. It was observed that on the completion of antidiabetic study, the formulation could bring the blood glucose level to normal in group rats. However, the blood glucose level was still elevated in group administered with pure gliplizide. It can be concluded that HRM can be used to formulate glipizide tablets. The formulations with HRM shows better hypoglycemic activity and this may be attributed to antidiabetic activity of Hibiscus rosasinensis.

Hibiscus Rosa-Sinensis Mucilage as a Functional Polymer in Pharmaceutical Applications: A Review

“…HRS mucilage is able to attach to powder mass and convert it into granules, which are further compressed into tablets. Based on a study by Bahadur et al [25], HRS mucilage can be used as a binder in the formulation of glipizide tablets, an antidiabetic medicine. They determined that HRS mucilage has strong binding properties since drug release was delayed as mucilage concentration increased.…”

Formulation and evaluation of inclusion complexed repaglinide with β-cyclodextrin transdermal patches

“…The spectra were recorded in the wavelength region between 4000 cm‾ 1 and 400cm‾ 1 . The spectra obtained for repaglidine and physical mixtures of drug with polymers were compared to study any possible drug polymer interactions [14][15][16][17].…”

Formulation and evaluation of theophylline sustained release matrix tablets using synthetic polymers

“…At started time interval, 5 ml of solution was analyzed spectrophotometrically at 272 nm after appropriate dilution. The volume of the dissolution medium was adjusted to 900 ml at every sampling time by replacing 5 ml with same dissolution medium [22][23][24][25].…”