Chronic diseases such as diabetes mellitus have high prevalence all over the world. The purpose of the study is to prepare a transdermal patch that can be used to treat diabetes, reducing pill burden and increasing patient compliance. Based on positive results of a feasibility study, including doctor’s opinion and prescription survey, repaglinide was selected as the active ingredients for developing a transdermal patch. The complexation of repaglinide and β cyclodextrin was done by grinding method. The present study was designed to develop Matrix type systems of transdermal patch containing repaglinide- β cyclodextrin complexes, using different polymeric combinations such as Hydroxy Propyl Methyl cellulose (HPMC), Ethyl Cellulose (EC), and Eudragit L100 with Poly vinyl pyrolidone (PVP) by solvent evaporation technique. The patches were subjected to physicochemical parameters, in-vitro drug release and in-vitro skin permeation studies. Good results were obtained in all the evaluated parameters. The developed transdermal delivery system containing complex of repaglinide and β cyclodextrin can further be studied for launching it in market.
A deeper study revealed that O. sanctum has been attributed with actions that can increase pitta and body heat. It is mentioned to be a microbicidal agent. Because of its pungent taste and sharp and dry properties, it can increase pitta (one of the three doshas representing heat, transformation, digestion and metabolism) and should not be used in high doses or for a prolonged period in individuals with predominance of pitta or in diseases caused by derangement of pitta and rakta (blood), pungent substances with sharp and dry properties and hot potency are not generally considered to be good for fertility and should be used with care as O. sanctum has pungent taste. In the classical formulations the quantity of O. sanctum to be consumed per day varied from 0.74 mg to 86.14 mg. The plant Tulsi or Holy Basil (Botanical name Ocimum sanctum) belongs to family Lamiaceae. It is a tropical plant which grows as weed and also cultivated. Tulsi is worshipped by Hindus and is an important symbol of Hindu religion. It is a very common sight to find Tulsi Vrindavan (A special structure where Tulsi is grown) in houses of Hindus.
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