Formulation and Evaluation of Colon Targeted Matrix Tablets Containing Extract of Solenostemma Argel (Hargel)

Maad, Abdullah Hameed; Shayoub, Mohammed Elhassan; Elnima, Elamin Ibrahim; Osman, Zuheir; Magbool, Fatehalrahman F.

doi:10.22270/ujpr.v4i4.297

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…It was noted when the tablet had completely broken down and no mass remained in the apparatus. 12,18…”

Section: Disintegration Studiesmentioning

confidence: 99%

Formulation and in vitro Evaluation of pH Dependent Colon Targeted Controlled Release Tablet of Mesalamine Containing Cyamopsis tetragonoloba Gum and Sodium Alginate

Mustafa,

Khan,

Ali

et al. 2023

Int J. Pharm. Investigation

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Curiosity in colon-specific drug delivery has increased recently due to an increasing number of colonic ailments, such as diverticulosis, polyps, Irritable Bowel Syndrome (IBS), Ulcerative Colitis (UC), local bacterial infections, colorectal cancer, Crohn's Disease (CD), intestinal wound healing, and fistula. 3 By utilizing a variety of techniques, such as incorporating tablets with pH-sensitive polymers, prodrugs, pressure-control systems, osmotic pumps, and gastrointestinal tablets, one can target drug delivery not only for localized colonic diseases but also for protein and peptide delivery. 4 The existence of microbial flora in the colon ABSTRACT Objectives: The goal of the study was to treat ulcerative colitis by targeting drug delivery to the colon via the novel ingredient's guar gum and pH-dependent polymer sodium alginate. The drug was released at a high pH in the colon due to the sodium alginates. Guar gum was a novel ingredient that was used as a release retarder, binder, and swelling agent. The galactomannan enzyme naturally degrades the guar gum. Because this enzyme is only found in the human body's GIT colon, the tablet colon is naturally target-specific. Materials and Methods: The tablet was prepared through wet granulation using an IPA solution. The formed granules subjected to the pre-formulation studies had free flow ability and a uniform size or shape. After the pre-formulations, the tablets were formed using the ZP-17 machine, and post-compression studies such as the hardness test, friability test, weight variation test, and thickness or diameter test were performed. Results: The precompression and post-compression studies, including the hardness test, friability test, weight variation test, and thickness or diameter test, were in the specification. The disintegration test was performed on the tablets, but due to the swelling nature of guar gum, they did not disintegrate. The dissolution studies were performed for 24 hr using acidic and basic buffers. The drug releases at a basic pH of 7.4 in the presence of the galactomannose enzyme, which shows its pH dependence and colon targeting. The various kinetic models were used to release kinetic models. According to the kinetic release studies, the R 2 explained that formulations were controlled releases and followed the zero order, which is independent of drug concentration.

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“…It was noted when the tablet had completely broken down and no mass remained in the apparatus. 12,18…”

Section: Disintegration Studiesmentioning

confidence: 99%

Formulation and in vitro Evaluation of pH Dependent Colon Targeted Controlled Release Tablet of Mesalamine Containing Cyamopsis tetragonoloba Gum and Sodium Alginate

Mustafa,

Khan,

Ali

et al. 2023

Int J. Pharm. Investigation

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A comprehensive review on buccal patches

Seema¹,

Kumar²,

Teotia³

2020

GSC Biol. and Pharm. Sci.

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Buccal Patches are the type of drug formulation that has normally a different course of administration through the buccal mucosa for drug delivery. The product is placed between upper gingiva (gums) and cheek to treat local and systemic conditions. Buccal patch have good accessibility to the membranes that line the oral cavity. These patches tend to help drug enter directly into the systemic circulation escaping hepatic first pass metabolism. This type of drug delivery method is considered useful for elevating the bioavailability of drugs. This review is a thorough study to apprehend the procedures involved in assessment of buccal patches and the modern approach towards this type of drug delivery. This article intends to analyze the overall profile of Buccal Patches and scope of future advances.

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Formulation and Evaluation of Colon Targeted Matrix Tablets Containing Extract of Solenostemma Argel (Hargel)

Cited by 2 publications

References 11 publications

Formulation and in vitro Evaluation of pH Dependent Colon Targeted Controlled Release Tablet of Mesalamine Containing Cyamopsis tetragonoloba Gum and Sodium Alginate

Formulation and in vitro Evaluation of pH Dependent Colon Targeted Controlled Release Tablet of Mesalamine Containing Cyamopsis tetragonoloba Gum and Sodium Alginate

A comprehensive review on buccal patches

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