The recent scientific and patented literature concluded that an increased interest in novel dosage forms which retained in the stomach for prolong and predictable period of time has been shown. Various technological attempts have been made in the research and development of rate controlled oral drug delivery systems to overcome physiological diversities, as short gastric residence times and unpredictable gastric emptying times using gastro retentive drug delivery system. The present study attempts to give an insight into the gastro-retentive drug delivery systems, and gastric floating dosage forms, in particular. These have attracted the interest of many formulators due to their advantages over the conventional drug delivery systems, recently. The study highlights these advantages with reference to the various types of gastro retentive drug delivery systems, as well as provides an overview of the recent advances that have taken place in this arena. It is a well known fact that differences in gastric physiology such as, gastric pH and motility exhibit both intra as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behavior. Various attempts have been made to develop gastroretntive systems. Several approaches are currently utilized in the prolongation of the GRT, including floating drug livery system, swelling and expanding systems, polymeric Bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices. Floating dosage forms are emerging as a promising dosage forms. Floating dosage forms can be prepared as tablets, capsules by adding suitable ingredients as well as by adding gas generating gent. In this review various techniques used in floating dosage forms along with current and recent developments of stomach specific floating drug delivery systems for gastro retention are discussed.

Liposome was derived from two Greek words “Lipos meaning fat and Soma meaning body”. Liposome were spherical shaped vesicles consist of phospholipids and cholesterol. Due to their size hydrophobic and lipophilic character   they are very promising system for drug delivery. This novel drug delivery system aims to target the drug directly to the site of action. Liposomes are very biocompatible and stable and have unique property to entrap both hydrophilic drug and lipophilic drug (amphiphatic nature) to its compartment and lead to   controlled release effect. They are of 0.05- 5.0 micrometer in diameter. Liposomes are used for the treatment of various diseases like tumors or cancer. This article provides an overview of Liposomal Drug Delivery System and various aspects related to liposome that can be studied. Keywords: Liposomes, novel delivery, amphiphatic, controlled release.

respectively. Maximum drug release after 20 h was 47.1, 55.7, 69.4 and 81.3 % for formulations F1, F2, F3 and F4, respectively. Scanning electron micrographs indicate pores both on the surface and interior of the microspheres. Conclusion:The developed curcumin microsphere system is a promising floating drug delivery system for oral sustained administration of curcumin.

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Transdermal route is an interesting option in this respect because a transdermal route is convenient and safe, avoid first pass metabolism, predictable and extended duration of activity, minimizing undesirable side effects, utility of short half-life drugs, improving physiological and pharmacological responses, avoiding the fluctuation in drug levels and inter and intra-patient variations. However it has got its own limitations its inability to transport large molecules, inability to overcome the barrier properties of stratum corneum and many more. Transfersomes hold great prospective in delivery of huge range of drug substances which includes large molecules like peptides, hormones and antibiotics, drugs with poor penetration due to unfavorable physicochemical characters. Formulating the drug in a transfersome is one such approach to solve these problems. Transfersome, is an ultradeformable vesicle, elastic in nature which can squeeze itself through a pore which is many times smaller than its size owing to its elasticity. Present article deals with the properties of transferosomes, method of preparation and different evaluation parameters.

Aim of novel drug delivery system is to enhance safety and efficacy of drug molecules by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach led to development of fast dissolving tablets. Nowadays fast disintegrating tablets (FDTs) gaining significance with wide variety of drugs serving many purposes. These are novel types of tablets that disintegrate/dissolve/disperse in saliva within few seconds (less than 60 seconds) without chewing and additional water. The basic approach used in development of FDTs is the use of superdisintegrants and the elimination of bitterness. FDTs reduces the disadvantages of conventional dosage form especially dysphasia (difficulty in swallowing) in pediatric and geriatric patients. These oral dosage forms have many benefits such as self medication, increased compliance, ease of manufacturing and noninvasive. This review presents description of fast dissolving tablets including need for development, challenges in formulation, suitability of drug candidates, composition, various technologies involved, advantages, disadvantages, and evaluation parameters.

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