Formulation and Evaluation of Chloramphenicol Hydrogel Ophthalmic Preparation

Kurniawansyah, Insan Sunan; Sopyan, Iyan; Wardhana, Yoga Windu; Gunasekaran, Mohanapriya

doi:10.5530/jyp.2018.2s.14

Cited by 6 publications

(11 citation statements)

References 2 publications

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“…Organoleptic evaluation was done by looking at the changes in the color, odor, and clarity of the preparation visually on the day of production and the 3 rd , 5 th , 7 th , 14 th , 21 th , and 28 th days of storage. It was expected that during the 28 storage days the preparation become colorless, clear, and odorless [26,27].…”

Section: Organolepticmentioning

confidence: 99%

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In situ ophthalmic gel forming systems of poloxamer 407 and hydroxypropyl methyl cellulose mixtures for sustained ocular delivery of chloramphenicole: optimization study by factorial design

Kurniawansyah

Rusdiana

Sopyan

et al. 2020

Heliyon

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Section: Organolepticmentioning

confidence: 99%

“…The measurements of pH were carried out on the day of production, and on the 3 rd , 5 th , 7 th , 14 th , 21 th and 28 th days of storage at room temperature. The pH ranges expected to maintain stability of the in situ gel preparations are 5-7.4 [26,27].…”

Section: Phmentioning

confidence: 99%

In situ ophthalmic gel forming systems of poloxamer 407 and hydroxypropyl methyl cellulose mixtures for sustained ocular delivery of chloramphenicole: optimization study by factorial design

Kurniawansyah

Rusdiana

Sopyan

et al. 2020

Heliyon

Self Cite

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“…The temperature was maintained at 37+0.5 °C with the speed of rotation maintained at 100 rpm. The samples were withdrawn at various time intervals and analysed spectrophotometrically for the drug content [1,[42][43][44][45][46].…”

Section: F In Vitro Studiesmentioning

confidence: 99%

A Review on Poloxamer and Hydroxy Propyl Methyl Cellulose Combination as Thermoresponsive Polymers in Novel Ophthalmic in Situ Gel Formulation and Their Characterization

et al. 2021

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Poor bioavailability is one of the most significant problems in the delivery of the ocular drug system. Ophthalmic ointments, solutions and suspensions are the most frequently used dosage forms to treat ocular disease, and their effectiveness as a drug are compromised by several limitations that lead to poor ocular bioavailability. In situ gel is one of the most promising strategy and solutions to improve the ocular bioavailability of drugs. The purpose of this review is to discuss the formulation and characterization of in situ gel. This review is written based on the data or information obtained by using several search engines and several scientific journals, focused on Poloxamer 407 and Hydroxy Propyl Methyl Cellulose (HPMC) bases combination. Active ingredients to treat ocular disease such as Ciprofloxacin, Fluconazole and Ofloxacin can be formulated with the combination of Poloxamer 407 as polymer gelling agent and HPMC as viscosity enhancer to produce good quality in situ gel dosage forms. The in situ gel dosage forms can be a promising alternate solution for the ophthalmic delivery system.

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“…Gel extract formulation: Extracts have been weighed according to the formula, put into mortars, added to the base gel little by a little while crushed until homogeneous [7]. (control blank); Group XVII: Alavie ® (positive control) market preparedness treatment; Group XVIII: Without treatment (negative control).…”

Section: Formulation Of Gelmentioning

confidence: 99%

Antiaging Activity of Gel Preparation Containing Three Varieties of Passion Fruit Peel Ethanolic Extract

Nazliniwaty¹,

Harun²,

Putra³

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Antiaging cosmetics are cosmetics that can prevent or correct the signs of premature aging. Passion fruit (Passiflora sp.) peel is an agricultural waste contains polyphenol compounds and flavonoids which are a source of natural antioxidants to prevent premature aging. The passion fruit peel extract formulated into gel preparations which can increase the economic value of the passion fruit peel waste. OBJECTIVE: The objective of the study was to test the antiaging activity of gel preparations containing ethanolic extracts of purple, red, and yellow passion fruit on experimental animal skins with several parameters (wrinkle, melanin, pore, moisture, and elasticity). METHODS: Gel was made by adding passion fruit peel extract with several concentrations (0.05%, 0.10%, 0.15%, 0.20%, and 0.25%) in gel base. The blank used is a gel base without extracts. Measurement of wrinkle, black pigment (melanin), pore size, moisture content, and elasticity was performed using a skin analyzer. The use of gel is done 2 times a day for 28 days. RESULTS: Gel with purple, red, and yellow passion fruit peel extract can be formulated into gel preparations. The higher concentration of passion fruit peel extract shows a higher antiaging activity. Gel preparations with purple, red, and yellow passion fruit peel extract, respectively, show the recovery of wrinkle 16.16%, 8.73%, and 6.49%; recovery of melanin 20.11%, 10.75%, and 8.06%; recovery of pore 18.78%, 10.15%, and 7.69%; recovery of moisture 32.74%, 17.70%, and 13.04%; and recovery of elasticity 30.08%, 16.13%, and 12.30%. CONCLUSIONS: The highest antiaging activity was given by gel preparations containing purple passion fruit peel extract and the lowest antiaging activity was given by gel preparations with yellow passion fruit peel extracts.

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Formulation and Evaluation of Chloramphenicol Hydrogel Ophthalmic Preparation

Cited by 6 publications

References 2 publications

In situ ophthalmic gel forming systems of poloxamer 407 and hydroxypropyl methyl cellulose mixtures for sustained ocular delivery of chloramphenicole: optimization study by factorial design

In situ ophthalmic gel forming systems of poloxamer 407 and hydroxypropyl methyl cellulose mixtures for sustained ocular delivery of chloramphenicole: optimization study by factorial design

A Review on Poloxamer and Hydroxy Propyl Methyl Cellulose Combination as Thermoresponsive Polymers in Novel Ophthalmic in Situ Gel Formulation and Their Characterization

Antiaging Activity of Gel Preparation Containing Three Varieties of Passion Fruit Peel Ethanolic Extract

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