Formulation and Evaluation of Anticancer Drug (Tamoxifen) Loaded Nanosponges

Abstract

The purpose of this research was to prepare Tamoxifen loaded Nanosponge gel for Sustained release of drug, increase the drug solubility, and increase the drug permeability, to reduce the dosing frequency and side effects. The FTIR studies proved that there were no interactions between the drug and Polymers. Homogenization technique followed by centrifugation was employed to prepare Nanosponge using various polymers. The formulation were prepared using different Polymers (hydroxy Ethyl cellulose and PVA) in different ratios (Drug:

Nanosponge-An Emerging Nanomaterial in Recent Advancement of Novel Drug Delivery: An Overview and Future Perspectives

“…It may assist in the process of material transferring i.e., liquid formulation can be converted to powder [36] . NSs are biodegradable [37] , free flowing [38] , and highly compatible with an extensive variety of substances [39] . They can offer extended release of drugs up to 12 h [40] .…”

The effect of formulation and process variables on prepared etoricoxib ‎Nanosponges

“…After that, the resulting drug solution was diluted with Dichloromethane, and the drug solution was tested for drug content with a UVspectrophotometer at the specific λmax [7]. The percentage of drug content in the obtained nanosponge was determined using the following equation [8]:…”

“…The entrapment efficiency was determined by dissolving 10 mg of dried NS in 10 ml of PBS of pH 7.4; in a volumetric flask, then put it in the bath sonicator for 1 minute. After centrifuging, the free drug remained in supernatant while entrapped drug retained in the NS; 1 ml from the clear solution was taken and filtered, diluted with PBS of pH 7.4 then the drug was detected by a UV spectrophotometric by using PBS of pH 7.4 as a blank, the measurement of drug EE% was carried out in triplicate, and average values used (8,9). The highest EE%, the greater the amount of drug entrapped inside each NS, drug entrapment efficiency can be determined by the following equation:…”

“…These spherical Ns are non-toxic, non-irritant, and stable at high temperatures up to 300 °C in comparison with other drug delivery systems, act preferentially as a topical delivery system, and may extend an incorporated drug for up to 12 hours. These structures have a wide range of pH (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) and self-sterilizing because of the average diameter of the cavity or pore (250 nm -1μm). Furthermore, formulations of NS are low-cost with free-flowing properties as general and highly compatible with a wide range of ingredients.…”

The ascension of nanosponges as a drug delivery carrier: preparation, characterization, and applications

“…NSs are solid in nature and are found to be safe to be administered by other routes [16]. For administering parenteral formulations, aqueous solutions like saline and sterile water are used as solvents for incorporating NSs containing drug [17]. For administering drugs via topical route, topical hydrogel is used to incorporate the NSs.…”