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The main objective of the present study was to design a controlled release dosage form for an oral anti diabetic drug i.e. repaglinide employing polymers like eudragit s- 100. One of the other objective of this present study was to increase the biological half-life the drug by formulating into microspheres. The microspheres of repaglinide were prepared by solvent evaporation method by using eudragit s-100 and ethyl cellulose as polymers with different concentrations. Formulations (F1-F10) were prepared and evaluated for various micrometric properties and it was observed that though all the formulations were exhibited good flow properties, The F5 formulation exhibits higher in- vitro buoyancy time and entrapment efficiency which is considered for in- vitro and mucoadhesive studies. The FTIR results reveal that there was no interaction between the drug and the excipients. The in- vitro release profiles of F1-F5 indicated that all formulations showed controlled release over an extended period, with acceptable release kinetics. Among the all formulations F5 were considered as a promising candidate for sustain release of repaglinide.
The main objective of the present study was to design a controlled release dosage form for an oral anti diabetic drug i.e. repaglinide employing polymers like eudragit s- 100. One of the other objective of this present study was to increase the biological half-life the drug by formulating into microspheres. The microspheres of repaglinide were prepared by solvent evaporation method by using eudragit s-100 and ethyl cellulose as polymers with different concentrations. Formulations (F1-F10) were prepared and evaluated for various micrometric properties and it was observed that though all the formulations were exhibited good flow properties, The F5 formulation exhibits higher in- vitro buoyancy time and entrapment efficiency which is considered for in- vitro and mucoadhesive studies. The FTIR results reveal that there was no interaction between the drug and the excipients. The in- vitro release profiles of F1-F5 indicated that all formulations showed controlled release over an extended period, with acceptable release kinetics. Among the all formulations F5 were considered as a promising candidate for sustain release of repaglinide.
Dengue is endemic in more than 100 countries and it is estimated that annually above 390 million infections occur globally. During the period between 1996-2015, a massive increase of more than 500 percent has been recorded in number of dengue cases reported in India. Dengue is a disease caused by any one of four closely related viruses (DEN-1, DEN-2, DEN-3, or DEN-4). The viruses are transmitted to humans by the bite of an infected mosquito (Aedes aegypti). The Aedes aegypti mosquito is the vector of dengue/dengue hemorrhagic fever. Dengue Hemorrhagic Fever is a more severe form of dengue. There is no specific medication for treatment of a dengue infection. In India mostly herbal products are majorly used for many treatments. The development of polyherbal formulation for Dengue Fever in the form of tablets was performed in this present study. The polyherbal tablets were prepared by using herbals like Andrographis paniculata Nees, Carica papaya Linn and Ocimum sanctum Linn leafs with excipients like Lactose Monohydrate, Microcrystalline Cellulose, Cross Povidone, Colloidal Silicon Dioxide, Methyl Paraben and Magnesium Stearate for the treatment of dengue fever. The plants are collected and plants materials was identified and authenticated taxonomically. The presence of active constituents in herbals was confirmed by preliminary phytochemical screening tests. The preformulation studies were carried out for the powder blends; it was evaluated to determine the bulk density, tapped density and the flow characteristics by angle of repose, carr’s index and hausner’s ratio. The data obtained from these studies indicated that the powder blends have good flow properties. The tablets were prepared with powdered herbals leafs and different ratios of excipients by direct compression. The formulated tablets were evaluated for physical characterization like appearance, weight variation, thickness, hardness, friability, and disintegration. Evaluation studies of all formulations shows that the weight variation, friability and disintegration complies with specification. The disintegration study of formulation F3 was concluded the best formulation among other formulation, which shows the faster disintegration. So, formulation F3 was considered as optimized formulation. Finally, among the three formulations, the formulation F3 showed better results than other formulations in respect of evaluation parameters.
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