Formosadimers A, B, and C from the Bark of Calocedrus macrolepis var. formosana

Abstract

Terpenes U 0200 Formosadimers A, B, and C from the Bark of Calocedrus macrolepis var. formosana -[isolation and structure elucidation of the abietane-O-abietane type title compounds (I)]. -(HSIEH, C.-L.; TSENG, M.-H.; KUO*, Y.-H.; Chem.

Naturally Occurring Diterpenoid Dimers: Source, Biosynthesis, Chemistry and Bioactivities

“…In a phytochemical investigation of the black heartwood of Cryptomeria japonica, sugikurojin B (30) was identified as a dimer of 6,7-dihydroxyferruginol and 6,7-dehydroferruginol with a 6-O-12′ linkage [41]. In chemical studies of the barks of Calocedrus macrolepis, five abietanoid dimers with the same linkage pattern as sugikurojin B were isolated, including formosadimers A-C (31-33) [42] and calocedimers C and D (34, 35) [43]. Formosaninol (36) and formosanin (37) were isolated from the heartwood of Juniperus formosana [44].…”

“…Obtusanols A and B have a rare peroxide bond linking two abietanoid units between C-7 and C-12′. In another study, bicunningines A and B (41,42) were isolated from Cunninghamia lanceolata [46].…”

Anti-lymphangiogenic diterpenes from the bark of Calocedrus macrolepis var. formosana

“…Previous studies of Calocedrus macrolepis Kurz var. formosana (Florin) W. C. Cheng & L. K. Fu identified various classes of chemical constituents, such as fatty acids, monoterpenes, shonanic acids [ 7 – 9 ], sesquiterpenes [ 10 ], diterpenes [ 4 , 11 – 15 ], furanones [ 10 ], sesquarterpene (C 35 ) [ 16 , 17 ], and lignans [ 4 ]. Some of them showed cytotoxicity [ 4 , 16 – 18 ], anti-inflammatory [ 19 ], anti-oxidant [ 19 , 20 ], anti-microbial [ 20 ], anti-plant pathogenic fungi [ 21 ], and arteriosclerosis prevention [ 14 ] activity.…”