2021
DOI: 10.1097/mao.0000000000003126
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Formations of Host Fibers and Bacteria in Human Temporal Bones With Otitis Media

Abstract: Hypothesis:In temporal bones with otitis media, fibrin and neutrophil extracellular traps (NETs) form a fibrous network with bacteria, which is involved in growth of bacterial clusters/biofilms and chronicity of disease.Background:NETs and fibrin are important in host defense against pathogens; however, their role in otitis media is not well understood.Methods:Eight human temporal bones with serous otitis media, 30 with serous-purulent otitis media, 7 with mucoid otitis media, 23 with mucoid-purulent otitis me… Show more

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Cited by 4 publications
(5 citation statements)
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“…The formation of NETs and biofilm promote each other [155,156]. Similar to what has been described for otitis media [157], these numerous fibers could be incorporated into the biofilm and help to reinforce the biofilm scaffold, so that therapeutically only mechanical removal is promising.…”
Section: Schematic Illustration Of the Discussed Pathogenesis Of Equi...mentioning
confidence: 69%
“…The formation of NETs and biofilm promote each other [155,156]. Similar to what has been described for otitis media [157], these numerous fibers could be incorporated into the biofilm and help to reinforce the biofilm scaffold, so that therapeutically only mechanical removal is promising.…”
Section: Schematic Illustration Of the Discussed Pathogenesis Of Equi...mentioning
confidence: 69%
“…It is conceivable that this network of fibrous material becomes integrated into the leptospiral biofilm, making pathogen elimination increasingly impossible, similar to what has been described for chronic recurrent otitis in children [449]. It is therefore clear why vitrectomy is the most effective treatment option for typical ERU.…”
Section: Vitreous Structure Eru and Biofilmmentioning
confidence: 89%
“…Fibrous material such as NET and fibrin is suggested to prevent the clearance of bacteria by phagocytic cells, and thus promotes the growth of bacterial clusters or biofilms. Fibrin and NETs are discussed to be important for the recurrence and chronicity of otitis media in children [449].…”
Section: Neutrophil Extracellular Traps (Nets)mentioning
confidence: 99%
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