Formation of trimethylsilyl derivatives of tetracyclines for separation and quantitation by gas-liquid chromatography

Tsuji, Kiyoshi; Robertson, J. H.

doi:10.1021/ac60334a037

Cited by 29 publications

(5 citation statements)

References 21 publications

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“…Other compounds examined are α‐tocopherol (vitamin E) (Liebler et al, ), hydroxypipecolic acids (Kitew & Hughes, ), menthols (Bournot et al, ), tetracyclines (Tsuji & Robertson, ), hydroxynoraporphines (Evans & Vouros, ), nicotinamine (Ripperger, ), flavonoids (Füzfai & Molnár‐Perl, ), bisphenol A (Szyrwińska et al, ), phytoestrogens (Ferrer et al, ), haplamine (Ea et al, ), cucurbic acid (Rontani et al, ), mycolic acids (Kaneda et al, ), N , N ‐dialkyl aminoethane‐2‐ols (Reddy et al, ), tricothecenes (Rodrigues‐Fo et al, ), β‐diketone‐containing plant waxes (Tulloch & Hogge, ), alkoxychlorohydrins (Zenkevich & Drugov, ), abietic acids (Azemard et al, ; Rontani et al, ), pectic oligosaccharides from artichoke (Sabater et al, ), lignans (Boldizsár, et al, ), vitamin B6 (Richter, et al, ) and polysaccharides from the Chinese medicinal herb Anemarrhena asphodeloides Bunge (Xia et al, ). Spectra of these compounds are mainly formed by α‐cleavages or cleavages and/or rearrangements of rings and do not present significant additional information on the general fragmentation of TMS derivatives discussed above.…”

Section: Trimethylsilyl Derivativesmentioning

confidence: 99%

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Harvey

Vouros

2019

Mass Spectrometry Reviews

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This review describes the mass spectral fragmentation of trimethylsilyl (TMS) and related alkylsilyl derivatives used for preparing samples for analysis, mainly by combined gas chromatography and mass spectrometry (GC/MS). The review is divided into three sections. The first section is concerned with the TMS derivatives themselves and describes fragmentation of derivatized alcohols, thiols, amines, ketones, carboxylic acids and bifunctional compounds such as hydroxy‐ and amino‐acids, halo acids and hydroxy ethers. More complex compounds such as glycerides, sphingolipids, carbohydrates, organic phosphates, phosphonates, steroids, vitamin D, cannabinoids, and prostaglandins are discussed next. The second section describes intermolecular reactions of siliconium ions such as the TMS cation and the third section discusses other alkylsilyl derivatives. Among these latter compounds are di‐ and trialkyl‐silyl derivatives, various substituted‐alkyldimethylsilyl derivatives such as the tert‐butyldimethylsilyl ethers, cyclic silyl derivatives, alkoxysilyl derivatives, and 3‐pyridylmethyldimethylsilyl esters used for double bond location in fatty acid spectra. © 2019 Wiley Periodicals, Inc. Mass Spec Rev 0000:1–107, 2019

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Section: Trimethylsilyl Derivativesmentioning

confidence: 99%

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Harvey

Vouros

2019

Mass Spectrometry Reviews

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“…To ensure human food safety, a few detection methods have been successfully proposed for determination of TCs, such as gel chromatography , LC , gas–liquid chromatography , and LC–MS/MS . For determination of TCs in milk powder samples, the first step is to purify the low concentrations of analytes in the samples, which requires long sample preparation time.…”

Section: Introductionmentioning

confidence: 99%

Analysis of tetracyclines from milk powder by molecularly imprinted solid‐phase dispersion based on a metal–organic framework followed by ultra high performance liquid chromatography with tandem mass spectrometry

Wang

Zhang

et al. 2018

J of Separation Science

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A novel molecularly imprinted polymer that could selectively recognize tetracyclines in milk powder was synthesized using a metal-organic framework as a support material, tetracycline as template molecule, and 3-aminophenylboronic acid as a functional monomer and a cross-linking agent. The novel molecularly imprinted polymer was characterized by Fourier transform infrared spectrometry, transmission electron microscopy, X-ray diffractometry, thermogravimetric analysis, and N adsorption/desorption measurements. The adsorption isotherms, adsorption kinetics, adsorption thermodynamics, and selective adsorption experiments of the novel molecularly imprinted polymer to tetracycline were also studied. The novel molecularly imprinted polymer was used as dispersant of matrix solid-phase dispersion to extraction tetracyclines. After that, the tetracyclines extracted from milk powder were determined by ultra high performance liquid chromatography with tandem mass spectrometry. Under the optimal conditions, the detection limits of tetracyclines were 0.217-0.318 ng/g. The relative standard deviations of intra- and interday precision ranged from 3.8 to 6.9% and from 2.8 to 7.4%, respectively. In all three concentration levels (1.0, 10, 50 ng/g), the recoveries of tetracyclines ranged from 84.7 to 93.9%. The method was successfully applied to the determination of tetracyclines in milk powder.

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“…Several methods have been used to determine doxycycline. [1][2][3][4][5][6][7][8][9][10][11] An optical sensor for doxycycline has been reported recently. 12 Though a fluorescent compound, carbazole has not been reported as an optical sensor up to now.…”

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Carbazole as Fluorescence Carrier for Preparation of Doxycycline Sensor

et al. 2003

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Carbazole is a promising pharmaceutical species. A novel optical sensor for determining doxycycline based on the fluorescence quenching of N-allylcarbazole immobilized on an quartz glass plate surface by covalent bonding has been described. The sensor shows satisfactory virtues in reversibility, repeatability, selectivity and sufficient lifetime resulting from its excellent optode membrane. Its response time is less than 60 s. The determination range and detection limit of the sensor are 6.0 × 10 -7 -2.0 × 10 -3 M and 2.0 × 10 -7 M, respectively. The lifetime of each sensor is at least three to four months. The sensor can be used for direct determination of doxycycline in pharmaceutical preparations and urine samples.

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Formation of trimethylsilyl derivatives of tetracyclines for separation and quantitation by gas-liquid chromatography

Cited by 29 publications

References 21 publications

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Mass Spectrometric Fragmentation of Trimethylsilyl and Related Alkylsilyl Derivatives

Analysis of tetracyclines from milk powder by molecularly imprinted solid‐phase dispersion based on a metal–organic framework followed by ultra high performance liquid chromatography with tandem mass spectrometry

Carbazole as Fluorescence Carrier for Preparation of Doxycycline Sensor

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