Carbazole as Fluorescence Carrier for Preparation of Doxycycline Sensor

Abstract

Carbazole is a promising pharmaceutical species. A novel optical sensor for determining doxycycline based on the fluorescence quenching of N-allylcarbazole immobilized on an quartz glass plate surface by covalent bonding has been described. The sensor shows satisfactory virtues in reversibility, repeatability, selectivity and sufficient lifetime resulting from its excellent optode membrane. Its response time is less than 60 s. The determination range and detection limit of the sensor are 6.0 × 10 -7 -2.0 × 10 -3 M and 2.0 × 10 -7 M, respectively. The lifetime of each sensor is at least three to four months. The sensor can be used for direct determination of doxycycline in pharmaceutical preparations and urine samples.

A rapid and sensitive assay for determination of doxycycline using thioglycolic acid-capped cadmium telluride quantum dots

“…Some of these methods are expensive, time-consuming and require expertise operator; however, fluorescence spectroscopy as a simple, efficient and sensitive method [23,24], has attracted interests for analysis of pharmaceutical compounds such as doxycycline. Nowadays, quantum dots (QDs), a type of photoluminescent semiconductor nanomaterials, have been widely used as fluorescent labels and have provided significant improvements in quantitative determinations.…”

Conjugated carbazole-thiophene copolymer: Synthesis, characterization and applications

“…A series of conjugated copolymer containing carbazole group was applied for organic solar cell [9], enhancement of bright pure blue-violet light with high quantum yield [10], recording media [11] and other interesting applications. And this polymer containning carbazole group is applied detecting material for chemical substance, because the nitrogen atom of the carbazole molecule has lone pair-electron [12][13][14][15][16][17][18][19][20]. In fact, carbazole and its derivatives have attracted much attention with it interesting characteristics for fabrication of fluorescent sensor [14][15][16][17]19,21].…”

DFT and experimental studies on structure and spectroscopic parameters of 3,6-diiodo-9-ethyl-9H-carbazole

“…Carbazole derivatives have very interesting photoconductivity [10] and optical [11] properties. Due to their fluorescent ability, carbazoles are used for the production of light emitting diodes (OLEDs) [12,13] and sensors [14][15][16][17]. For these reasons, there is a constant search for new carbazole derivatives as potential substrates for new materials with promising optoelectronic properties.…”

“…Molecular modeling of NMR parameters is widely used to support assignments of experimental spectra [19][20][21]. Satisfactory chemical shifts for several different nuclei including 13 C, 17 O, 15 N and 19 F [19,[22][23][24][25] can be obtained by density functional theory calculations in combination with gauge including atomic orbitals (GIAO) [26,27] and employing the Becke, three-parameter, Lee-Yang-Parr (B3LYP) [27,28] or BHandHLYP hybrid half-and-half functional [29]. In particular the latter was used to predict accurate NMR parameters.…”