Formation of multifunctional ZrO2–MgO-hBN nanocomposite for enhanced bone regeneration and E coli bacteria filtration applications

Hussain, Ajaz; Gautam, Chandkiram; Jafri, Asif; Mishra, Vijay Kumar; Madheshiya, Abhishek; Gautam, Amarendra; Singh, Manvandra Kumar; Gautam, Rakesh Kumar; Gupta, Manisha; Ali, Arshad; Vajtai, Róbert; Ajayan, Pulickel M.

doi:10.1016/j.ceramint.2020.06.077

Cited by 13 publications

(6 citation statements)

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“…[27] The remarkable properties of h-BN have stimulated a great deal of research and have established h-BN as a promising material for a wide range of applications, including infrared nanophotonics, quantum photonics, nonlinear optics, and deep-UV optoelectronics, [28] in addition to applications in nanocomposite ceramics for multifunctional biomaterials. [29] Strong Coulomb interactions in h-BN lend excitonic effects a major role in determining the electronic structure and the optical response of h-BN. [30][31][32] The physical mechanisms leading to the bright UV emission of h-BN have been object of debate.…”

Section: Introductionmentioning

confidence: 99%

Ellipsometry Study of Hexagonal Boron Nitride Using Synchrotron Radiation: Transparency Window in the Far‐UVC

Artús

Feneberg

Attaccalite

et al. 2021

Advanced Photonics Research

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The linear optical response of the ultrawide bandgap h‐BN is investigated by spectroscopic ellipsometry. The ordinary dielectric function of h‐BN is determined up to 25 eV on a high‐quality single‐crystal platelet. The direct bandgap and the high‐energy transitions are characterized with the aid of ab initio self‐consistent GW calculations and the optical properties are calculated using the Bethe–Salpeter equation. The dispersion of the ordinary refractive index in the visible and UV part of the spectrum below the bandgap is in excellent agreement with previous transmission experiments. A sharp excitonic peak at 6.1 eV associated with the direct bandgap dominates the absorption spectrum, and a second peak is observed at 6.8 eV. At higher energies, a strong absorption peak emerges at 15 eV associated with higher σ → σ* transitions. As a consequence of the unique electronic band structure of h‐BN, a transparency window is observed in the far‐UV region between 7 and 13 eV, where the light penetration depth reaches a value of 38 nm, as opposed to the value of 0.8 nm at the absorption peak of the fundamental bandgap.

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Section: Introductionmentioning

confidence: 99%

Ellipsometry Study of Hexagonal Boron Nitride Using Synchrotron Radiation: Transparency Window in the Far‐UVC

Artús

Feneberg

Attaccalite

et al. 2021

Advanced Photonics Research

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“…These were characterized by low density, high strength, and mesoporous interconnected architecture. The materials exhibited interesting properties due to their stability in water, minimum essential medium eagle-α modification (α-MEM), acids, and oils (e.g., suitable proliferation of osteoblast such as MG63 cells or filtration of E. coli from water [194]). Magnesium-enriched GO nanoscrolls (MgNPs@GNSs) were designed for the combinational modulation of the inflammatory response.…”

Section: Silicates and Claysmentioning

confidence: 99%

Advances in Use of Nanomaterials for Musculoskeletal Regeneration

Jampílek

Plachá

2021

Pharmaceutics

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Since the worldwide incidence of bone disorders and cartilage damage has been increasing and traditional therapy has reached its limits, nanomaterials can provide a new strategy in the regeneration of bones and cartilage. The nanoscale modifies the properties of materials, and many of the recently prepared nanocomposites can be used in tissue engineering as scaffolds for the development of biomimetic materials involved in the repair and healing of damaged tissues and organs. In addition, some nanomaterials represent a noteworthy alternative for treatment and alleviating inflammation or infections caused by microbial pathogens. On the other hand, some nanomaterials induce inflammation processes, especially by the generation of reactive oxygen species. Therefore, it is necessary to know and understand their effects in living systems and use surface modifications to prevent these negative effects. This contribution is focused on nanostructured scaffolds, providing a closer structural support approximation to native tissue architecture for cells and regulating cell proliferation, differentiation, and migration, which results in cartilage and bone healing and regeneration.

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“…Recently, nanomaterials with various nanostructures, such as nanoparticles, nanotubes, and nanosheets, have attracted great interest as promising drug carriers or antibacterial agents, attributed to their unique physicochemical, optical, electrical, and mechanical properties as well as tunable structures. − Among them, hexagonal boron nitride (h-BN), as a kind of two-dimensional material, exhibits outstanding biocompatibility, environmental safety, and lower cytotoxicity in comparison with carbon-based nanomaterials. − Despite high chemical inertness and strong oxidation resistance, it is still possible for BN nanosheets to biodegrade in the lungs . h-BN has a lamellar structure with a hexagonal honeycomb shape composed of boron (B) and nitrogen (N) atoms, which in combination with homogeneous interlayer channels and stacked layers, tunable surface modification, adjustable structures, and stable properties can serve as one of the promising inorganic nanocarriers. − In our previous work, boron nitride nanosheets (BNNSs) exfoliated from h-BN possess abundant edge defect sites and hydrophobic properties, which facilitate the introduction of functional groups and the loading of active ingredients through hydrophobic and π–π interactions. − Additionally, BNNSs with fewer layers by exfoliation possess considerable mechanical properties and sharp edges, which can cause physical damage in bacterial cells, also realize a synergistic bacteriostatic effect with active ingredients, and thus improve antibacterial activity . Moreover, the lamellar properties of the BNNSs are favorable for spreading and adhesion on various surfaces, thus reducing the deterioration, degradation, and leaching off of active ingredients .…”

Section: Introductionmentioning

confidence: 99%

Large Ultrathin Polyoxomolybdate-Decorated Boron Nitride Nanosheets with Enhanced Antibacterial Activity for Infection Control

Zheng

Guan

et al. 2023

ACS Appl. Nano Mater.

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To address the challenges in bacterial infection for killing germs without using antibiotics, the development of an efficient and safe antibacterial nanomaterial to control severe bacterial infection has become a critical issue. Herein, ionic liquid (IL)-promoted simultaneous exfoliation and conjugation of boron nitride nanosheets (BNNSs) with ammonium dimolybdate (ADM) are developed. Such an approach provides large ultrathin nanosheets with three to four layers and micron lateral dimensions and facilitates intercalation with a molybdenum (Mo) content of 6.25%. BNNS-IL-ADM provides nanoconfinement inducing capability for sustained release of Mo ions to decelerate the cumulative release rate by 30.45%. BNNS-IL-ADM imparts a superior antibacterial effect especially at a low concentration level of bioactive components, which improves the antibacterial efficiency by 92.00% against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus in comparison with ADM. The enhanced antibacterial performance is strongly dependent on the synergistic effect between the BN nanocarrier and bioactive ADM, in which the bacterial cell adhesion induced by the inherent hydrophobic property of the BNNS and the nanochannels within BNNS-IL-ADM protecting the bioactive ingredient and achieving a sustained release play significant roles. BNNS-IL-ADM can serve as a safe and efficient antibacterial agent with very low cytotoxicity. Such features offer a feasible strategy for simultaneous exfoliation and functionalization of boron nitride nanosheets as a promising platform for the delivery of bioactive ingredients against bacterial infections.

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Formation of multifunctional ZrO2–MgO-hBN nanocomposite for enhanced bone regeneration and E coli bacteria filtration applications

Cited by 13 publications

References 58 publications

Ellipsometry Study of Hexagonal Boron Nitride Using Synchrotron Radiation: Transparency Window in the Far‐UVC

Ellipsometry Study of Hexagonal Boron Nitride Using Synchrotron Radiation: Transparency Window in the Far‐UVC

Advances in Use of Nanomaterials for Musculoskeletal Regeneration

Large Ultrathin Polyoxomolybdate-Decorated Boron Nitride Nanosheets with Enhanced Antibacterial Activity for Infection Control

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