Formation of mannitol core microparticles for sustained release with lipid coating in a mini fluid bed system

Wang, Bifeng; Frieß, Wolfgang

doi:10.1016/j.ejpb.2017.09.003

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…That was because the larger cores carried a thicker lipid layer under the same lipid to mannitol ratio. On the other hand, as expected, sparingly water-soluble methyl blue showed a lower release rate than freely soluble aspartame (34). For hydrophilic drugs, their relatively faster release rate and poor intestinal absorption are both against the preparation of sustained-release dosage forms.…”

Section: Fluid Bed Coating Techniquesupporting

confidence: 58%

“…What's more, the size and solubility of inner cores might also be factors associated with the sustained release behavior. In a study, methyl blue and aspartame, sparingly and freely water-soluble materials, respectively, were used as model drugs and coated with a lipid film by fluidized bed coating (34). Thereinto, drug-loaded mannitol microparticles with the size of 500 or 300 μm served as inner cores and two lipids 'hard fat and glyceryl stearate' acted as coating materials.…”

Section: Fluid Bed Coating Techniquementioning

confidence: 99%

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Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems

et al. 2019

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Particle engineering has become a hot topic in the field of modified-release delivery systems during last decades. It has a wide range of pharmaceutical applications and is a bridge linking between drugs and drug delivery systems. Particles are an important part of many dosage forms and viewed as a carrier of drugs. Their size, shape, crystalline form, and structure directly affect the stability and releasing pattern of drugs. Engineering size or modifying particles by forming porous, core-shell, or skeleton structures can realize the development and utilization of functionally modified release systems (including fast-release systems, sustained-release systems, and targeted-release systems). However, there are certain problems in the practical application, such as bitter taste and coating damage. Combining with some polymer or lipid materials to form core-shell or embedded structures is considered as the key to taste masking. And, using cushioning agents is proven to be effective in preserving the integrity of the functional coating film of multiparticulates during tableting. To sum up, this review, from a particle engineering point, expounds the influence of different factors on the functionality of particles and offers some useful comments and suggestions for industry personnel.

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Section: Fluid Bed Coating Techniquesupporting

confidence: 58%

Section: Fluid Bed Coating Techniquementioning

confidence: 99%

Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems

et al. 2019

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“…Moreover, the quadratic effects (X1 2 and X2 2 ) as well as the interactive effect on pellet wet mass torque were not significant, as their recorded p values were higher than 0.05 in all cases (Table 4a). The antagonistic effect of mannitol on the wet mass consistency (especially when lower PVP concentration was used as the binder solution) may be due to the hydrophilic nature of mannitol (Wang and Friess, 2017). This hydrophilic nature allows good wetting of the powder bed with the binder solution, which results in a subsequent reduction in the wet mass consistency (torque).…”

Section: Resultsmentioning

confidence: 99%

Utilizing mixer torque rheometer in the prediction of optimal wet massing parameters for pellet formulation by extrusion/spheronization

Ibrahim

Zayed

Alsharif

et al. 2019

Saudi Pharmaceutical Journal

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In this study, we aimed to optimize theophylline pellet formulations using a two-factor three-level full-factorial design (32) by monitoring the concentration of two pellet excipients, polyvinyl pyrrolidone K30 (PVP) binder solution (X1) and the hydrophilic excipient mannitol (X2). Their impact on pellet characteristics (responses) were evaluated. Increasing PVP concentration in the binder solution resulted in an increase in the wet mass torque value. The effect of mannitol, however, was antagonistic. Moreover, the pellet particle size was significantly influenced by the level of mannitol, PVP solution, and quadratic effect of mannitol. Mannitol significantly antagonized the pellet particle size. Furthermore, increased mannitol concentrations significantly enhanced drug dissolution rate from the pellets, whereas PVP concentration in the binder solution significantly reduced the drug dissolution rate. In conclusion, wet granulations can be controlled by monitoring the composition of the binder solution and pellet composition.

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“…The dissolution in coated tablets is controlled by properties of the film such as composition, thickness, pore size, number of pores, coating weight, etc. [ 12 , 13 ]. Typically, dissolution is empirically determined, which is a tedious and time-consuming process.…”

Section: Introductionmentioning

confidence: 99%

Development of a Multivariate Predictive Dissolution Model for Tablets Coated with Cellulose Ester Blends

et al. 2020

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The focus of the present investigation was to develop a predictive dissolution model for tablets coated with blends of cellulose acetate butyrate (CAB) 171-15 and cellulose acetate phthalate (C-A-P) using the design of experiment and chemometric approaches. Diclofenac sodium was used as a model drug. Coating weight gain (X1, 5, 7.5 and 10%) and CAB 171-15 percentage (X2, 33.3, 50 and 66.7%) in the coating composition relative to C-A-P and were selected as independent variables by full factorial experimental design. The responses monitored were dissolution at 1 (Y1), 8 (Y2), and 24 (Y3) h. Statistically significant (p < 0.05) effects of X1 on Y1 and X2 on Y1, Y2, and Y3 were observed. The models showed a good correlation between actual and predicted values as indicated by the correlation coefficients of 0.964, 0.914, and 0.932 for Y1, Y2, and Y3, respectively. For the chemometric model development, the near infrared spectra of the coated tablets were collected, and partial least square regression (PLSR) was performed. PLSR also showed a good correlation between actual and model predicted values as indicated by correlation coefficients of 0.916, 0.964, and 0.974 for Y1, Y2, and Y3, respectively. Y1, Y2, and Y3 predicted values of the independent sample by both approaches were close to the actual values. In conclusion, it is possible to predict the dissolution of tablets coated with blends of cellulose esters by both approaches.

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Formation of mannitol core microparticles for sustained release with lipid coating in a mini fluid bed system

Cited by 4 publications

References 31 publications

Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems

Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems

Utilizing mixer torque rheometer in the prediction of optimal wet massing parameters for pellet formulation by extrusion/spheronization

Development of a Multivariate Predictive Dissolution Model for Tablets Coated with Cellulose Ester Blends

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