Utilizing mixer torque rheometer in the prediction of optimal wet massing parameters for pellet formulation by extrusion/spheronization

Ibrahim, Mohamed A.; Zayed, Gamal; Alsharif, Fahd M.; Abdelhafez, Wael A.

doi:10.1016/j.jsps.2018.10.002

Cited by 9 publications

(6 citation statements)

References 13 publications

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“…Each wet massing measuring cycle involved 60 s for mixing and 20 s for data logging (gathering). During the wet massing procedures, the consistency of pellet wet mass (represented by the mean line torque; Nm) was computed [21]. Moreover, the binder ratio (mL of PVP binder solution required for 1 g of powder to attain wet mass peak torque) was determined.…”

Section: Assessment Of Pellet Wet Mass (Mixer Torque Rheometry (Mtr))mentioning

confidence: 99%

“…A similar finding was obtained by Ibrahim et al [27], who revealed an inverse relationship between the peak torque values of pellet wet mass and indomethacin release rate from pellet formulations. Moreover, Ibrahim et al [21] indicated that at a low pellet wet mass, the peak torque was associated with small pellet size and, hence, a rapid drug release rate.…”

Section: Effect On In Vitro Releasementioning

confidence: 99%

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Development and Characterization of Eudragit-RL-100-Based Aceclofenac Sustained-Release Matrix Pellets Prepared via Extrusion/Spheronization

Ibrahim

Alshora

2021

Polymers

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Aceclofenac (AC) is a nonsteroidal anti-inflammatory drug used in the treatment of chronic pain in conditions such as rheumatoid arthritis, with frequent administration during the day. The formulation of sustained release matrix pellets can provide a promising alternative dosage form that controls the release of the drug, with less blood fluctuation and side effects—especially those related to the gastric system. The extrusion/spheronization technique was used to formulate AC matrix pellets. The response surface methodology (version 17.2.02.; Statgraphics Centurion) was used to study the impacts of Eudragit RL 100 and PVP K90 binder solution concentrations on the pellets’ wet mass peak torque, pellet size, and the release of the drug. Statistically, a significant synergistic effect of PVP K90 concentration on the peak torque and pellet size was observed (p = 0.0156 and 0.031, respectively), while Eudragit RL 100 showed significant antagonistic effects (p = 0.042 and 0.013, respectively). The peak torque decreased from 0.513 ± 0.022 to 0.41 ± 0.021 when increasing the Eudragit RL 100 from 0 to 20%, and the pellet size decreased from 0.914 ± 0.047 to 0.789 ± 0.074 nm. The tested independent factors did not significantly affect the drug release in the acidic medium within 2 h, but these pellet formulae maintained the drug release at less than 10% in the acidic medium (pH 1.2), which may decrease gastric irritation side effects. In contrast, a highly significant synergistic effect of Eudragit and highly antagonistic effect of the PVP solution on drug release in the alkaline-pH medium were observed (p = 0.002 and 0.007, respectively). The optimized pellet formula derived from the statistical program, composed of 3.21% Eudragit and 5% PVP solution, showed peak torque of 0.861 ± 0.056 Nm and pellet size of 1090 ± 85 µm, and resulted in a significant retardation effect on the release after 8 h compared to the untreated drug.

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Section: Assessment Of Pellet Wet Mass (Mixer Torque Rheometry (Mtr))mentioning

confidence: 99%

Section: Effect On In Vitro Releasementioning

confidence: 99%

Development and Characterization of Eudragit-RL-100-Based Aceclofenac Sustained-Release Matrix Pellets Prepared via Extrusion/Spheronization

Ibrahim

Alshora

2021

Polymers

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“…Wet powder rheometry is used to determine the granulation point of pharmaceutical formulations [24,26]. This method uses a mixer torque rheometer (MTR), and the software can be programmed to perform an analysis of the components of a formulation to obtain the exact amount of binding liquid and subsequently determine whether the flow of the granules is adequate to assess whether it will be difficult to compress in a compression machine.…”

Section: Introductionmentioning

confidence: 99%

Using Chia Powder as a Binder to Obtain Chewable Tablets Containing Quinoa for Dietary Fiber Supplementation

da Silva,

Reyes,

Daniel

et al. 2024

Powders

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The consumption of fiber in the human diet is a global recommendation to ensure a healthy diet. Quinoa (Chenopodium quinoa Willd.), a gluten-free grain, and chia (Salvia hispanica), a seed, contain a high fiber content, and both have the potential to be used in the development of nutraceutical and pharmaceutical formulations. An interesting characteristic of chia is its ability to form viscous mucilage when in contact with water, making it a potential binder in solid formulations. However, there are no studies on chia as a binder, and therefore, the objective of the present study was to evaluate the feasibility of using chia as a binder to produce quinoa granules and, subsequently, develop chewable tablet formulations. The quinoa and chia were in a powder form and then transformed into a wet mass with the help of mixer torque rheometer (MTR) equipment. In the wet granulation form, the following parameters were tested: multiple additions, 15 g of material, and 25 timepoints for the addition of 1 mL of water. An experimental design was carried out to evaluate the impact of the variables on the MTR results for subsequent granulation. The granulation point was possible for T1–T9, and most formulations gave satisfactory results, such as an acceptable resistance of the granules. In the end, a formulation was selected for the development of chewable tablets containing quinoa and chia fibers.

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“…A tool that has been explored to determine the granulation point of pharmaceutical formulations is wet powder rheometry [18,20]. The equipment is the Mixer Torque Rheometer (MTR) which, by simple programming the method and weighing 15-22 grams of each sample, is capable of indicating the granulation point by the relation of torque (Nm) versus Binder Ratio (mg.mL).…”

Section: Introductionmentioning

confidence: 99%

Use of Chia as a Binder to Obtain Chewable Tablets Containing Quinoa for Dietary Fiber Supplementation

Da Silva,

Reyes,

Daniel

et al. 2023

Preprint

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The consumption of fiber in the human diet is a global recommendation to ensure a healthy diet. Quinoa (Chenopodium quinoa Willd.), a gluten-free grain, and chia (Salvia hispanica), a seed, contain high fiber content and both have the potential to be explored in the development of nutraceutical and pharmaceutical formulations. An interesting characteristic of chia is its ability to form viscous mucilage when in contact with water, bringing the prospect of a binder in solid formulations. To produce tablets with a high fiber content, it is more appropriate to transform the material into granules using a wet process, with the help of a tool that exploits this possibility. Therefore, the objective of the present work was to study, using the Mixer Torque Rheometer, the feasibility of using chia as a binder to produce granulated quinoa and the development of chewable tablets. To this end, an experimental design was carried out to evaluate the impact of variables on the rheometer results for subsequent granulation. It was possible to obtain the granulation point for the formulations and after producing the granules, physical tests were carried out in which we noticed improvements in the flow. In the end, a formulation was selected for the development of chewable tablets containing quinoa and chia fibers.

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Utilizing mixer torque rheometer in the prediction of optimal wet massing parameters for pellet formulation by extrusion/spheronization

Cited by 9 publications

References 13 publications

Development and Characterization of Eudragit-RL-100-Based Aceclofenac Sustained-Release Matrix Pellets Prepared via Extrusion/Spheronization

Development and Characterization of Eudragit-RL-100-Based Aceclofenac Sustained-Release Matrix Pellets Prepared via Extrusion/Spheronization

Using Chia Powder as a Binder to Obtain Chewable Tablets Containing Quinoa for Dietary Fiber Supplementation

Use of Chia as a Binder to Obtain Chewable Tablets Containing Quinoa for Dietary Fiber Supplementation

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