Formation of DNA adducts using nickel(II) complexes of redox-active ligands: a comparison of salen and peptide complexes

The interaction of native DNA with iron(III)-N,N′-ethylene-bis(salicylideneiminato)-chloride

“…Moreover, the affinity of Fe(Salen)Cl for the oxygen molecule and the capability to form oxo-complexes is similar to what observed for Fe III porphyrin derivatives [21,22] and for all the transition metal-Salen complexes showing the property to cleave DNA [11][12][13][14][15][16][17][18][19].…”

“…The interaction of H 2 Salen transition metal complexes, including Cu [11,12], Ni [11,[13][14][15], Mn [11,16,17], Co [11,18] and Ru [19], with DNA was studied and great changes of spectroscopic properties were generally noticed, indicating binding interactions between DNA and such compounds. An intercalating interaction mode was proposed for Co(Salen) [11,18]; an external binding with the surface of the double helix was suggested for a functionalized Cu(Salen) complex [11,12], while Ni(Salen) presented a high affinity toward the N7 atom of guanosine residues [11,[13][14][15].…”

“…An intercalating interaction mode was proposed for Co(Salen) [11,18]; an external binding with the surface of the double helix was suggested for a functionalized Cu(Salen) complex [11,12], while Ni(Salen) presented a high affinity toward the N7 atom of guanosine residues [11,[13][14][15]. Moreover, all the investigated transition metal-Salen complexes showed the ability to cleave DNA via redox processes [11][12][13][14][15][16][17][18][19]. The solubilities of these metal complexes in water solutions usually increase by functionalizing the ligand by means of polar groups [11][12][13][14][15][16][17][18][19].…”

“…Moreover, all the investigated transition metal-Salen complexes showed the ability to cleave DNA via redox processes [11][12][13][14][15][16][17][18][19]. The solubilities of these metal complexes in water solutions usually increase by functionalizing the ligand by means of polar groups [11][12][13][14][15][16][17][18][19].…”

The interaction of native DNA with Zn(II) and Cu(II) complexes of 5-triethyl ammonium methyl salicylidene orto-phenylendiimine

“…Since H 2 Salen and most of its derivatives are usually sparingly soluble in water [23], the synthesis of water-soluble derivatives is an important first step for possible applications in biological systems. To this aim, an increasing number of papers have been reported to introduce charged groups to the salicylidene or diamine moieties [24][25][26][27]. In particular, it has been reported that cationic Schiff base complexes of copper(II) strongly interact with DNA by groove or intercalating binding mode, depending on the size and the nature of the substituents [27].…”