Formation of biocompatible MgO/cellulose grafted hydrogel for efficient bactericidal and controlled release of doxorubicin

Shahzadi, Iram; Islam, Muhammad; Saeed, Hamid; Haider, Ali; Shahzadi, Anum; Haider, Junaid; Ahmed, Nadeem; Ul‐Hamid, Anwar; Nabgan, Walid; Ikram, Muhammad; Rathore, Hassaan Anwer

doi:10.1016/j.ijbiomac.2022.08.142

Cited by 71 publications

(30 citation statements)

References 59 publications

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“…Sybyl-X2.0 was used for molecular docking investigations ( Mehmood et al, 2022 ; Shahzadi et al, 2022 ). Water molecules and co-crystallized ligands were eliminated to create a protein structure.…”

Section: Experimental Partmentioning

confidence: 99%

Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis

et al. 2023

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The emergence of multi-drug resistance (MDR) in aquatic pathogens and the presence of cationic dyes are the leading causes of water contamination on a global scale. In this context, nanotechnology holds immense promise for utilizing various nanomaterials with catalytic and antibacterial properties. This study aimed to evaluate the catalytic and bactericidal potential of undoped and Sr-doped Cr2O3 nanostructures (NSs) synthesized through the co-precipitation method. In addition, the morphological, optical, and structural properties of the resultant NSs were also examined. The optical bandgap energy of Cr2O3 has been substantially reduced by Sr doping, as confirmed through extracted values from absorption spectra recorded by UV-Vis studies. The field-emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) micrographs illustrate that the composition of Cr2O3 primarily consisted of agglomerated, irregularly shaped NSs with a morphology resembling nanoflakes. Moreover, the presence of Sr in the lattice of Cr2O3 increased the roughness of the resulting NSs. The catalytic activity of synthesized NSs was analyzed by their reduction ability of Rhodamine B (RhB) dye in the dark under different pH conditions. Their antibacterial activity was evaluated against MDR Escherichia coli (E. coli). Sr doping increased antibacterial efficiency against MDR E. coli, as indicated by inhibition zone measurements of 10.15 and 11.75 mm at low and high doses, respectively. Furthermore, a molecular docking analysis was conducted to determine the binding interaction pattern between NSs and active sites in the target cell protein. The findings corroborated antimicrobial test results indicating that Sr-Cr2O3 is the most effective inhibitor of FabH and DHFR enzymes.

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Section: Experimental Partmentioning

confidence: 99%

Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis

et al. 2023

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“…Similar to our earlier study, SYBYL-X 2.0 was employed to create 3D structures of the compounds and analyze nanoparticle binding affinities using active site residues of the chosen proteins. 45,46 3…”

Section: Molecular Docking Studiesmentioning

confidence: 99%

Molybdenum-doped iron oxide nanostructures synthesized via a chemical co-precipitation route for efficient dye degradation and antimicrobial performance: in silico molecular docking studies

et al. 2022

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“…GO/PAA-SnO 2 (100 mg: 0.06–1) exhibited highest scavenging performance of up to 53.45% at a 250 μg/mL concentration and scavenged DPPH radicals. The formation of highly reactive • OH and • O 2 radical species can interact with DPPH free radicals and results in its degradation, 67 which is highly correlated with the standard (ascorbic acid).…”

Section: Resultsmentioning

confidence: 99%

Bactericidal Action and Industrial Dye Degradation of Graphene Oxide and Polyacrylic Acid-Doped SnO₂Quantum Dots:In SilicoMolecular Docking Study

et al. 2023

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The present work demonstrates the systematic incorporation of different concentrations of graphene oxide (GO) into a fixed amount of polyacrylic acid (PAA)-doped SnO 2 quantum dots (QDs) through a coprecipitation approach. The research aimed to evaluate the catalytic and antibacterial actions of GO/PAA-SnO 2 QDs. Moreover, optical properties, surface morphologies, crystal structures, elemental compositions, and d-spacings of prepared QDs were examined. X-ray diffraction patterns revealed the tetragonal configuration of SnO 2 , and the crystallinity of QDs was suppressed upon dopants verified by the SAED patterns. Electronic spectra identified the blue shift by incorporating GO and PAA led to a reduction in band gap energy. Fourier transform infrared spectra showed the existence of rotational and vibrational modes associated with the functional groups during the synthesis process. A drastic increase in the catalytic efficacy of QDs was observed in the neutral medium by including dopants, indicating that GO/PAA-SnO 2 is a promising catalyst. GO/PAA-SnO 2 showed strong bactericidal efficacy against Escherichia coli (E. coli) at higher GO concentrations. Molecular docking studies predicted the given nanocomposites, i.e., SnO 2 , PAA-SnO 2 , and GO/PAA-SnO 2 , as potential inhibitors of beta-lactamase E. coli and DNA gyrase E. coli .

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Formation of biocompatible MgO/cellulose grafted hydrogel for efficient bactericidal and controlled release of doxorubicin

Cited by 71 publications

References 59 publications

Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis

Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis

Molybdenum-doped iron oxide nanostructures synthesized via a chemical co-precipitation route for efficient dye degradation and antimicrobial performance: in silico molecular docking studies

Bactericidal Action and Industrial Dye Degradation of Graphene Oxide and Polyacrylic Acid-Doped SnO₂Quantum Dots:In SilicoMolecular Docking Study

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Formation of biocompatible MgO/cellulose grafted hydrogel for efficient bactericidal and controlled release of doxorubicin

Cited by 71 publications

References 59 publications

Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis

Strontium-doped chromium oxide for RhB reduction and antibacterial activity with evidence of molecular docking analysis

Molybdenum-doped iron oxide nanostructures synthesized via a chemical co-precipitation route for efficient dye degradation and antimicrobial performance: in silico molecular docking studies

Bactericidal Action and Industrial Dye Degradation of Graphene Oxide and Polyacrylic Acid-Doped SnO2Quantum Dots:In SilicoMolecular Docking Study

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Bactericidal Action and Industrial Dye Degradation of Graphene Oxide and Polyacrylic Acid-Doped SnO₂Quantum Dots:In SilicoMolecular Docking Study