Forestalling the Epidemics of Parkinson's Disease Through Plant-Based Remedies

Banjari, Ines; Marček, Tihana; Tomić, Svetlana; Waisundara, Viduranga Y.

doi:10.3389/fnut.2018.00095

Cited by 20 publications

(15 citation statements)

References 66 publications

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“…It may be related to mitochondrial dysfunction, oxidative stress, genetics and the environmental factors. Clinical pathological diagnosis of PD is rather difficult 6 . Therefore, screening accurate and objective PD‐related diagnostic indicators has always been an important mission for majority of medical workers.…”

Section: Introductionmentioning

confidence: 99%

Serum lipids and the pathogenesis of Parkinson's disease: A systematic review and meta‐analysis

Jin

Zhao

2020

Int J Clin Pract

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Background The role of serum lipids in the pathogenesis of Parkinson's disease (PD) remains unclear, and the results of previous reports remain conflicting. We aimed to conduct this systematic review and meta‐analysis to identify the potential relationships of blood lipids and the pathogenesis of PD. Methods PubMed, Medline, Web of Science, Cochrane Library, and China National Knowledge Infrastructure (CNKI) databases were searched from inception to March 31, 2020, to identify potential studies with case‐control or cohort study design on the relationship of serum lipids and PD. Stata 15.1 software was used for data syntheses after extraction of relevant data. Results A total of 12 studies with 1506 PD patients and 7330 healthy controls were included. There were no significant differences in the TC (SMD = −0.08, 95% CI [−0.45, 0.33]), LDL‐C (SMD = −0.12, 95% CI [−0.46, 0.18]), and TG (SMD = −0.05, 95% CI [−0.18, 0.06]) among PD patients and healthy controls. There was significant difference (SMD = −0.32, 95% CI [−0.42, −0.25]) in the TG level among PD patients and healthy controls. Subgroup analysis by Asian and non‐Asian countries indicated that geographical location was not the source of heterogeneity. And no significant publication bias was found (all P > .05). Conclusions TG serum levels are significantly lower in PD patients, more studies are needed to further elucidate role of lipid in the PD development.

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Section: Introductionmentioning

confidence: 99%

Serum lipids and the pathogenesis of Parkinson's disease: A systematic review and meta‐analysis

Jin

Zhao

2020

Int J Clin Pract

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“…Secara keseluruhan PD lebih banyak ditemukan pada laki-laki daripada perempuan dengan perbandingan 3:2 (Muliawan et al, 2018). Prevalensinya diprediksi akan meningkat dua kali lebih banyak pada tahun 2030 (Banjari et al, 2018), dan lima kali lebih banyak pada tahun 2050 (Savica et al, 2016). Dampak yang akan terjadi jika PD tidak terobati yaitu dapat mengganggu aktivitas sehari-hari, kualitas hidup menurun, usia harapan hidup pendek, serta membutuhkan lebih banyak biaya untuk perawatan (Anitasari et al, 2017).…”

Section: Pendahuluanunclassified

Kajian potensi antioksidan dari tanaman herbal dan pengaruhnya terhadap penyakit Parkinson

Pratiwi¹,

Aligita²,

Kaniawati³

2021

JIF

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Background: Parkinson's disease is the most common neurodegenerative disorder affecting more than 10 million people worldwide. This disease is characterized by progressive dopaminergic neuron damage in the substantia nigra. This damage can be triggered by aging and the presence of oxidative stress because of free radicals. Antioxidants can inhibit the formation of free radicals and reduce oxidative stress, so they can be used as an alternative treatment for Parkinson's disease. Objective: This review article aimed to provide information about the antioxidant effects of selected herbal plants on Parkinson's disease. Method: This study used literature study methods sourced from national and international scientific journals published in the last 5 years (2016-2020). Literature search were carried out using databases such as Google Scholar, PubMed®, ScienceDirect, and Garuda Portal. Results: The high content of antioxidants in plants could protect nerve cells from oxidative damage and reduce symptoms such as tremors, muscle stiffness, impaired coordination and motor balance in test animals. Conclusion: Natural antioxidants from herbal plants proved to be able to prevent oxidative stress caused by free radicals and reduce symptoms of Parkinson's disease. Keywords: Parkinson's disease, antioxidants, oxidative stress, herbal plants

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“…Болезнь Паркинсона -это многофакторное расстройство нервной системы, основными характеристиками которого являются прогрессирующая дегенерация дофаминергических нейронов в nigra pars compacta нигростриарного тракта и последующий дефицит нейротрансмиттера дофамина в областях мозга, приводящие к потере моторной функции, появлению немоторных симптомов, ригидности, брадикинезии или акинезии, моторного блока, снижению когнитивных функций. Недавние исследования показали, что окислительный стресс, митохондриальная дисфункция и нарушение системы убиквитин-протеасома являются основными факторами, влияющими на патогенез болезни Паркинсона [1][2][3].…”

Section: Introductionunclassified

Review of Mucuna pruriens L. therapeutic potential for Parkinson’s disease

et al. 2020

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Parkinson’s disease is a multifactorial disorder of the nervous system, the main features of which are progressive degeneration of dopaminergic neurons in the nigra pars compacta nigrostriatal tract and subsequent deficiency of the neurotransmitter dopamine in the areas of the brain, leading to the loss of motor function, the emergence of non-motor symptoms, rigidity, akinesia or bradykinesia, motor block, and decline in cognitive functions. Parkinson’s disease has high prevalence throughout the world, and has no curative treatment in modern medicine. The available drugs such as anticholinergics, levodopa and a DOPA-decarboxylase inhibitor provide symptomatic relief only. Although dopaminergic therapy is the standard treatment of motor disabilities associated with Parkinson’s disease, it does not managed all the aspects of the disease. For this reason, the increasing numbers of patients are looking for more holistic approach to the treatment of this disease. Mucuna pruriens L. – an annual self-pollinating legume plant, can be considered as a potential complementary therapy for patients with Parkinson’s disease, as it is an extremely rich source of levodopa. Numerous studies have shown that Mucuna pruriens extracts restore biochemical and behavioral abnormalities in animals with the experimental model of Parkinson’s disease. The plant also demonstrates some antioxidant activity. The clinical effects of high-dose Mucuna pruriens are similar to levodopa, but have a more favorable tolerance profile. If long-term use of Mucuna pruriens proves safe and effective in controlled clinical trials, it could become a sustainable complementary therapy for the treatment of Parkinson’s disease, especially in low-income countries.

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Forestalling the Epidemics of Parkinson's Disease Through Plant-Based Remedies

Cited by 20 publications

References 66 publications

Serum lipids and the pathogenesis of Parkinson's disease: A systematic review and meta‐analysis

Serum lipids and the pathogenesis of Parkinson's disease: A systematic review and meta‐analysis

Kajian potensi antioksidan dari tanaman herbal dan pengaruhnya terhadap penyakit Parkinson

Review of Mucuna pruriens L. therapeutic potential for Parkinson’s disease

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