BACKGROUND: Diabetes Mellitus (DM) is a heterogeneous group of disorders characterized by increasing blood glucose levels caused by insufficiency of insulin hormone production and activities. There are significant increases in DM case every year in Indonesia, as a consequent, alternative and better drug is needed to be developed. One of the plants that were often used as traditional medicine for DM in Indonesia was Muntingia carabula L. (kersen) leaf. The aim of this research was to evaluate the antidiabetes activity of M. carabula leaves.METHODS: This study was conducted in vivo by evaluating the antidiabetic activity of M. carabula leaf water extract on two animal models, those are insulin deficiency and insulin resistant model animal. The insulin deficiency animal model was developed by aloxan administration at dose of 50 mg/Kg body weight (bw) intravenously. While the insulin resistance animal model was developed by lipid emulsion administration at dose of 0.42 mL/20 grams bw orally. Both groups were randomly devided into 6 groups, which are negative control group, positive control group, standard drug group (glybenclamide 0.65 mg/Kg bw or metformin 135 mg/Kg bw), and extract groups at dose of 100, 200 and 400 mg/Kg bw. Parameters which were evaluated are fasting blood glucose (FBG) levels for insulin deficiency models and values of constant of insulin tolerance (KITT) for insulin resistant models.RESULTS: In insulin deficient model group, administration of glibenclamide lower the FBG by 43%, furthermore, the extract of M. calabura at doses of 100, 200 and 400 mg/Kg bw also lower the FBG by 13%, 22% and 29%, subsequently. In insulin resistant models, metformin increased the value of KITT from less than 0.5 to 2.91, and administration of the extract at doses of 400, 200 and 100 mg/Kg bw also increased the KITT value to 2.31, 1.57, 1.13, respectively.CONCLUSION: The conclusion was M. carabula leaves water extract with dose of 400 mg/Kg bw had the antidiabetic activities with mechanisms to lower blood glucose level, regenerate pancreatic β cells, and increase insulin sensitivity.KEYWORDS: diabetes mellitus, kersen leaves, Muntingia calabura L., insulin deficiency, insulin resistance
Objective: Inflammation is body reactions in response to tissue injury and infection. In 2011, non-steroidal anti-inflammatory drug (NSAID) was thehighest demand drug in Indonesia. However, long-term treatment using NSAID can cause several side effects to cardiovascular and digestive system.This research aimed to investigate anti-inflammatory properties of binahong leaves (Anredera cordifolia) and pegagan herbs (Centella asiatica).Methods: Ethyl alcohol extract of A. cordifolia leaves and C. asiatica herbs was evaluated for its anti-inflammatory properties using human redblood cell (RBC) – membrane stabilization assay. The extract concentrations used in this study was 100, 200, 400, and 800-ppm, and apigenin andasiaticoside concentration were 1, 2, 3, 4, 5, 6, 10, and 100 ppm. Diclofenac natrium (DN) was used as a standard drug.Results: The results showed that A. cordifolia extract (ACE) alone, C. asiatica extract (CAE) alone, and the combination of ACE and CAE could inhibit thehemolysis of RBC in hypotonic solution. The optimum concentration for ACE alone was 100 ppm; for CAE alone was 400 ppm; and for the combinationof ACE and CAE was 50 ppm and 50 ppm, respectively. Apigenin and asiaticoside in concentration of 1-10 ppm showed more than 97% inhibition ofhemolysis. DN as a standard drug showed optimum inhibition at concentration of 400 ppm.Conclusion: The ethyl alcohol extract of A. cordifolia leaves and C. asiatica herbs showed anti-inflammatory activity, both as a single treatment or ascombinations, and apigenin and asiaticoside were responsible for anti-inflammatory activity in C. asiatica.Keywords: Anti-inflammation, Human red blood cell – membrane stabilization, Anredera cordifolia, Centella asiatica.
PARTNER VILLAGE IN FAMILY MEDICINE PLANT CULTIVATION TOWARDS CIBIRU WETAN VILLAGE AS A HERBAL CENTER. The area of Cibiru Wetan Village is a farming area because besides the limited water supply, the land is hilly. With the initiative and participation of women farmer groups which had so many achievements and skills, it was necessary to explore the potential that could provide a new icon for Cibiru Wetan Village. The purpose of the activity was to socialize and practice the cultivating of the medicinal plants carried out by a group of women farmers with simple and effective technology and finally able to become a center of dried herbs production. The method used in the cultivation program for medicinal plants was divided into three stages. The first stage was to provide material counseling on family medicinal plants including the understanding of the benefits of the plant, the second stage was to provide an explanation or training in planting family medicinal plants and the last stage or third stage was to practice directly in planting these medicinal plants. The results showed a positive understanding of both groups for both the socialization and counseling stages as well as for the practice of medicinal plants cultivation. It could be concluded, the partner village activities in medicinal plants cultivation could improve the understanding of the target group.
Diabetes mellitus is a heterogeneous group of disorders characterized by increasing blood glucose level caused by lack of insulin hormone. One of the plants that were often used as traditional medicine for diabetes in Indonesia was okra (Abelmoschus esculentus L.) fruit. The aim of this research was to evaluate the antidiabetes activity of okra fruit extract. The study was divided into several steps: a preliminary study of anthyperglycemia of okra fruit after glucose, sucrose, and amylum administration; antidiabetic activity in insulin deficiency animal model developed by aloxan administration and insulin resistance animal model developed by lipid emulsion administration, and in vitro study of α-glucosidase and α-amylase enzyme inhibition activity. The result showed that the extract group had antihyperglycemia activity after glucose, sucrose, and amylum administration. In insulin deficiency animal model, glibenclamide and extract could decrease blood glucose level. In insulin resistance animal, metformin and extract could increase constantly of insulin tolerance test. From the α-glucosidase inhibition activity, it was known the acarbose's IC50 was 44.374 µg/mL, while okra fruit extract was 1533.742 µg/mL. And the IC50 value of acarbose to α-amylase enzyme was 46.821 µg / mL, while okra fruit extract was 1228.469 µg / mL. In conclusion, okra (Abelmoschus esculentus L.) fruit extract with a dose of 50 mg/kg bw had the antidiabetic activity with the mechanism of action by increasing insulin secretion, increasing insulin sensitivity, and inhibiting carbohydrate absorption in the intestine; but couldn't inhibit alpha-glucosidase and alpha-amylase enzyme.
POTENTIAL DEVELOPMENT OF WOMAN FARMING GROUP IN THE UTILIZATION OF THE YARD FOR DRUG AND COSMETICS PLANTS USING VERTICAL GARDEN METHOD IN CIBIRU WETAN VILLAGE, BANDUNG REGENCY. The village of Cibiru Wetan is largely a rice field and swidden area with hilly contours and insufficient water availability. One of the utilization of fields with a lack of water is by growing plants that require minimal water, including medicinal plants and cosmetics. The initiation of this activity has a high prospect of success due to the high initiative and participation of the population in the form of women's farmer groups and the family welfare team as evidenced by the many achievements, awards, and skills gained by the Cibiru Wetan Village through the participation of its citizens. Therefore, the purpose of the project activity was socialization and practice at women’s farmer group of Cibiru Wetan Village through the use of medicinal plants and cosmetics with simple appropriate technology through vertical gardening. The method of implementation used in the training program for planting medicinal plants was divided two stage, that was providing information about family medicinal plants ranging from understanding to the benefits of the plants, and the last step was explaining or training and direct practice of planting medicinal plants and cosmetics using vertical planting. The results showed a positive understanding of the two groups of women’s farmer group I and II and the family welfare team, both for the stage of socialization and counseling as well as for the practice phase of planting medicinal plants and cosmetics vertically. The conclusion was the use of medicinal plants and cosmetics could increase the understanding of the target group and the compost produced by residents could be utilized through this activity.
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