Forensic electrochemistry: simultaneous voltammetric detection of MDMA and its fatal counterpart “Dr Death” (PMA)

Cumba, Loanda R.; Smith, Jamie P.; Zuway, Khaled Y.; Sutcliffe, Oliver B.; Carmo, Devaney Ribeiro do; Banks, Craig E.

doi:10.1039/c5ay02924d

Cited by 56 publications

(33 citation statements)

References 49 publications

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“…Their novel electrochemical protocol was independently validated in a synthetic MDMA/PMA sample with HPLC. 12 The continuous and progressive increase in the adulteration of common illicit street drugs causes overdoses, sometimes with fatal consequences. The need for the development of sensitive, selective and reliable analytical protocols for their separation and quantication is being addressed by the simultaneous electrochemical (amperometric) detection using a commercially available impinging jet ow-cell that incorporates in-house SPEs demonstrating high sensitivity and reproducibility for the analysis of illicit drugs of abuse in the presence of common adulterants (e.g.…”

Section: Introductionmentioning

confidence: 99%

¹H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

2019

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Section: Introductionmentioning

confidence: 99%

¹H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

2019

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“…The development of screen-printed electrodes (SPEs) has become a major revolution in the construction of electrochemical sensors/biosensors [32]. The SPEs have been designed especially for miniaturization of electrochemical analytical systems [33].…”

Section: Introductionmentioning

confidence: 99%

Nonenzymatic coated screen-printed electrode for electrochemical determination of acetylcholine

Mohammadi

Beitollahi

Tajik

2018

Micro and Nano Syst Lett

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In the present study, a screen-printed electrode based-sensor with electrochemical detection was developed for rapid and sensitive determination of acetylcholine. At first, the screen-printed carbon electrode was modified by using a magnetic core shell and then was used for voltammetric determination of acetylcholine in ampoule, serum and urine samples. The electrochemical behaviour of acetylcholine at the modified electrode was investigated by cyclic voltammetry. The modified electrode displayed a decrease in the overpotential (ca. 130 mV) and an obvious increase in the peak current compared to the non-modified screen-printed electrode. The results indicated that modified screenprinted electrode enhanced electrocatalytic activity towards the oxidation of acetylcholine. Under optimized conditions, the limit of detection from the experiment of acetylcholine determination was 0.02 µM with acetylcholine concentration in range of 0.1-500.0 µM. The reproducibility of the measurements was tested by recording the responses for 50.0 µM acetylcholine with four different developed sensors prepared on the same manner and the same day. A relative standard deviation value of 4.3% was obtained. Finally, a recovery test is done as a part of accuracy evaluation of the system. which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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“…The development of the screen-printed electrodes (SPEs) has become a major revolution in the construction of electrochemical sensors/biosensors. 21 The SPEs have been designed especially for the miniaturization of the electrochemical analytical systems. 22 SPEs are highly-versatile, easy to use, cost-effective analytical tools, also suitable to miniaturization.…”

mentioning

confidence: 99%

Screen printed carbon electrode modified with magnetic core shell manganese ferrite nanoparticles for electrochemical detection of amlodipine

Mohammadi

Tajik

Beitollahi

2019

JSCS

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In the present work, a rapid and sensitive detection of the amlodipine (AML) based on the modified screen printed carbon electrode (SPCE) is developed. At first, SPCE was modified with magnetic core shell manganese ferrite nanoparticles (MCSNP). Cyclic voltammetry (CV) was used to study the electrochemical behaviour of AML and its determination was conducted by applying differential pulse voltammetry (DPV). The results were showed that, the modified SPCE in comparison with unmodified SPCE exhibited the enhanced electrocatalytic activity toward the oxidation of AML. A single irreversible oxidation peak was observed at a potentials of 600 and 725 mV (on the scale of Ag/AgCl electrode) on the modified SPCE and unmodified SPCE, respectively. Under the optimized conditions, the anodic peak current of AML recorded by DPV varies linearly with AML concentration in the range 0.5-400 µM with a detection limit of 0.1 µM. The modified SPCE was used for the quantitative analysis of AML in AML tablet and urine samples and the results indicated the feasibility of the developed method for AML analysis in routine detection.

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Forensic electrochemistry: simultaneous voltammetric detection of MDMA and its fatal counterpart “Dr Death” (PMA)

Abstract: For the first time MDMA and PMA are simultaneously detected using electrochemical techniques.

Cited by 56 publications

References 49 publications

¹H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

¹H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

Nonenzymatic coated screen-printed electrode for electrochemical determination of acetylcholine

Screen printed carbon electrode modified with magnetic core shell manganese ferrite nanoparticles for electrochemical detection of amlodipine

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Forensic electrochemistry: simultaneous voltammetric detection of MDMA and its fatal counterpart “Dr Death” (PMA)

Abstract: For the first time MDMA and PMA are simultaneously detected using electrochemical techniques.

Cited by 56 publications

References 49 publications

1H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

1H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

Nonenzymatic coated screen-printed electrode for electrochemical determination of acetylcholine

Screen printed carbon electrode modified with magnetic core shell manganese ferrite nanoparticles for electrochemical detection of amlodipine

Contact Info

Product

Resources

About

¹H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

¹H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues