Foot‐and‐mouth disease vaccine production and research in the Netherlands

Barteling, S. J.

doi:10.1080/01652176.1987.9694134

Cited by 5 publications

(2 citation statements)

References 48 publications

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“…In 1950, this inactivation method, using in vitro culture technology on viable tongue epithelium, allowed FMD virus growth for vaccine production on a large scale [ 27 ]. Neither mass vaccine production nor a systematic annual vaccination program against FMDV were begun till early 1950 [ 28 ]. However, in 1953, the Netherlands launched a yearly cattle vaccination program using the ‘’Frenkel type’’ of vaccine.…”

Section: Introductionmentioning

confidence: 99%

B and T Cell Epitopes of the Incursionary Foot-and-Mouth Disease Virus Serotype SAT2 for Vaccine Development

Wubshet

Wang

et al. 2023

Viruses

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Failure of cross-protection among interserotypes and intratypes of foot-and-mouth disease virus (FMDV) is a big threat to endemic countries and their prevention and control strategies. However, insights into practices relating to the development of a multi-epitope vaccine appear as a best alternative approach to alleviate the cross-protection-associated problems. In order to facilitate the development of such a vaccine design approach, identification and prediction of the antigenic B and T cell epitopes along with determining the level of immunogenicity are essential bioinformatics steps. These steps are well applied in Eurasian serotypes, but very rare in South African Territories (SAT) Types, particularly in serotype SAT2. For this reason, the available scattered immunogenic information on SAT2 epitopes needs to be organized and clearly understood. Therefore, in this review, we compiled relevant bioinformatic reports about B and T cell epitopes of the incursionary SAT2 FMDV and the promising experimental demonstrations of such designed and developed vaccines against this serotype.

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Section: Introductionmentioning

confidence: 99%

B and T Cell Epitopes of the Incursionary Foot-and-Mouth Disease Virus Serotype SAT2 for Vaccine Development

Wubshet

Wang

et al. 2023

Viruses

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“…Because of the cell culture-based vaccine production process, the efficiency of FMD vaccine production could vary based on the type of cell culture medium used as have been demonstrated in the case of other cell-based viral vaccines (Sanson et al 2017;Dill et al 2018;Bissinger et al 2019). Originally, most of the animal vaccines were produced with serum-containing media, and the use of bovine serum-containing basal media has been reported in the early production stages of FMD vaccines (Barteling 1987). However, in recent times, animal component-free media or chemically defined media are preferred by pharmaceuticals owing a lower number of concerns regarding lot-to-lot variation and unintended contamination caused by adventitious micro-organisms (Merten 2002).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the optimal medium and application strategy for foot‐and‐mouth disease vaccine antigen production

Kim

Park

et al. 2021

J of Applied Microbiology

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Aims: For the effective production of 146S particles, which determines footand-mouth disease (FMD) vaccine efficacy, we aimed to identify the optimal medium that is easy-to-use, productive and economically affordable for the large-scale production of FMD vaccine. Methods and Results: Nine combinations of cell growth media and replacement media were tested for virus propagation. Apart from the replacement strategy, we tested a simple addition strategy involving the addition of 30% v/v of fresh medium to the total spent medium using the Cellvento BHK-200 (Vento). Unlike other tested media that produced poor yields of 146S particles when the spent media were not eliminated, Vento exhibited high productivity with the 30% addition strategy. Conclusions: Considering its lower price and media consumption compared to those of other media that require media replacement, the 30% addition strategy of Vento is highly effective. Furthermore, owing to its simple application strategy, it makes the scale-up process easy and helps in saving the time and labour involved in spent media removal. Significance and Impact of the Study: Through the first comparative assessment of commercial media for the 146S particle recovery, this study suggests the best practical medium for the industrial-scale production of FMD vaccines.

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Modern Inactivated Foot-and-Mouth Disease (FMD) Vaccines

Barteling¹

2004

Foot and Mouth Disease

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Foot‐and‐mouth disease vaccine production and research in the Netherlands

Abstract: Summary The paper reviews developments in foot-and-mouth disease research with an emphasis on the Netherlands and research developments at the Central Veterinary Institute.

Cited by 5 publications

References 48 publications

B and T Cell Epitopes of the Incursionary Foot-and-Mouth Disease Virus Serotype SAT2 for Vaccine Development

B and T Cell Epitopes of the Incursionary Foot-and-Mouth Disease Virus Serotype SAT2 for Vaccine Development

Investigation of the optimal medium and application strategy for foot‐and‐mouth disease vaccine antigen production

Modern Inactivated Foot-and-Mouth Disease (FMD) Vaccines

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