Foods from Mayan Communities of Yucatán as Nutritional Alternative for Diabetes Prevention

Narvaez, Jonatan Jafet Uuh; Campos, Maira Rubí Segura

doi:10.1089/jmf.2019.0125

Cited by 7 publications

(6 citation statements)

References 71 publications

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“…The rind of the fruit is recommended for the treatment of diabetes [ 126 , 139 , 141 ]. The pharmacological properties of watermelon have been identified as antibacterial, antifungal, antiulcer, anti-inflammatory, anti-prostatic hyperplasia, anti-atherosclerotic, gastroprotective, analgesic, hepatoprotective, antioxidant and antidiabetic [ 139 , 141 , 142 ]. Among the main phytochemicals detected in watermelon are carotenoids, which represent from 31% (yellow pulp cultivar) to 99% (red pulp cultivar) of the percentage of total carotenoids.…”

Section: Selected Species Of the Cucurbitaceae Family Used In Mexico ...mentioning

confidence: 99%

“…L-citrulline is involved in the production of endogenous nitroxide (NO), which is considered essential for regulating vasodilatation, immune responses, neurotransmission, and the adhesion of platelets and leukocytes. Thus, in recent years, the potential benefits of supplementing L-citrulline have been explored in cardiometabolic areas that include skeletal muscle and adipose tissue metabolism [ 142 , 144 ].…”

Section: Selected Species Of the Cucurbitaceae Family Used In Mexico ...mentioning

confidence: 99%

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Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus

et al. 2022

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In Mexico, Diabetes mellitus (DM) is a serious health problem, and although the current pharmacological treatments for DM such as insulin and oral hypoglycemics are available, the Mexican population continues to use medicinal plants in the treatment of DM. The antidiabetic properties of the plant species that belong to the Cucurbitaceae family has already been recognized worldwide. Since Mexico is one of the most important centers of diversity of Cucurbitaceae, the present work contributes to the review of the most used species of Cucurbitaceae in the treatment of DM in Mexico. The reviewed species (Cucurbita ficifolia, C. maxima, C. moschata, C. pepo, Ibervillea sonorae, Sechium edule, Citrullus lanatus, Cucumis melo, and C. sativus) revealed that the antidiabetic effects exerted are effective in a number of mechanisms involved in the complex pathogenesis of DM: hypoglycemic, antioxidant, anti-inflammatory, anti-obesity, protective effects on diverse organs and cells, as well as in the control of dyslipidemias; furthermore, the select species of the Cucurbitaceae family could also be essential components of diets for the control of DM in patients with the disease. Thus, the Cucurbitaceae species selected in the present work represent a source of antidiabetic agents that perhaps establish the bases for novel clinical treatments.

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Section: Selected Species Of the Cucurbitaceae Family Used In Mexico ...mentioning

confidence: 99%

Section: Selected Species Of the Cucurbitaceae Family Used In Mexico ...mentioning

confidence: 99%

Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus

et al. 2022

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“…Therefore, BC can be isolated or present in plant extracts and have therapeutic potential by exerting effects on different diseases such as T2D. Some compounds present in plants, such as polysaccharides, galactomannan gums, peptidoglycans, guanidines, glycopeptides, triterpenoids, alkaloids, amino acids, steroids, phenolic acids, flavonoids, and carotenoids, have been shown to inhibit the activity of AMY and GLU enzymes, an antidiabetic effect (Ardalani et al, 2021; Uuh Narvaez & Segura Campos, 2020).…”

Section: Bioactive Compounds: An Alternative In the Treatment Of T2dmentioning

confidence: 99%

Combination therapy of bioactive compounds with acarbose: A proposal to control hyperglycemia in type 2 diabetes

Narvaez

Campos

2022

Journal of Food Biochemistry

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Type 2 diabetes (T2D) is a chronic metabolic disease with a high impact on public health and social welfare. Hyperglycemia is a characteristic of T2D that leads to different complications. Acarbose (ACB) reduces hyperglycemia by inhibiting α‐amylase (AMY) and α‐glucosidase (GLU) enzymes. However, ACB causes low adherence to treatment by patients with diabetes due to its side effects. Consequently, reducing the side effects produced by ACB without compromising its efficacy is a challenge in treating T2D. Bioactive compounds (BC) are safe and could decrease the side effects compared to antidiabetic drugs such as ACB. Nevertheless, their efficacy alone concerning that drug is unknown. The scientific advances have been directed toward searching for new approaches, such as combination therapies between BC and ACB. This review analyzes the combined therapy of BC (extracts or isolates) with ACB in inhibiting AMY and GLU as a proposal to control hyperglycemia in T2D. Practical application Postprandial hyperglycemia is one most typical signs of type 2 diabetes, and it can have significant consequences, including cardiovascular problems. Acarbose has side effects that lead to the abandonment of treatment. Bioactive compounds in extracts or isolated forms have become a viable option for controlling hyperglycemia without side effects, but their administration alone is insufficient. The scientific advances of acarbose/bioactive compound combination therapy as a proposal for controlling hyperglycemia in T2D were analyzed. The findings suggested that bioactive compounds combined with acarbose are effective when they function synergistically or additively; however, they are not recommended in therapy when they have an antagonistic effect.

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“…Plant food compounds, such as polyphenols, especially flavonoids, phenolic acids, tannins, phytosterols, vitamins, triterpenoids, and carotenoids, have been shown antidiabetic effects (Ardalani et al, 2021;Uuh Narvaez & Segura Campos, 2020). Bioactive compounds can impact glucose regulation by inhibiting the activity of carbohydrate hydrolyzing enzymes (α-amylase and α-glucosidase), which are essential to slow glucose uptake and prevent postprandial hyperglycemia (Gothai et al, 2016;Zhu et al, 2019).…”

Section: Effect Of Bioactive Compounds On T2dm and Their Mechanism Of Actionmentioning

confidence: 99%

“…The antidiabetic effects of foods have often been attributed to the presence of chemical compounds called bioactive compounds. T2DM prevention and management (Alkhatib et al., 2017; Gothai et al., 2016; Russell et al., 2016; Uuh Narvaez & Segura Campos, 2020).…”

Section: The Alternative In the Prevention Of T2dm: Functional Foods And Bioactive Compoundsmentioning

confidence: 99%

Cabbage (Brassica oleracea var. capitata): A food with functional properties aimed to type 2 diabetes prevention and management

Narvaez

Campos

2021

Journal of Food Science

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Type 2 diabetes mellitus (T2DM) is increasing the prevalence worldwide at an alarming rate, becoming a serious public health problem that mainly affects developing countries. Functional food research is currently of great interest because it contributes to developing nutritional therapy strategies for T2DM prevention and treatment. Bioactive compounds identified in some plant foods contribute to human health by mechanisms of action that exert biological effects on metabolic pathways involved in the development of T2DM. Hence, vegetables with high bioactive compounds content may be a source of functional value for the control of T2DM. Cabbages varieties (Brassica oleracea var. capitata) such as green (GCB), white (WCB), and red (RCB) are foods consumed (raw or cooked) and cultivated in different regions of the world. Scientific evidence shows that cabbage has multi-target effects on glucose homeostatic regulation due to its high content of bioactive compounds. It has also been shown to decrease damage to organs affected by T2DM complications, such as the liver and kidney. Additionally, it could contribute as a preventive by attenuating problems underlying the development of T2DM as oxidative stress and obesity. This review highlights the functional properties of cabbage varieties involved in glucose regulation and the main mechanisms of the action exerted by their bioactive compounds. In conclusion, cabbage is a valuable food that can be employed as part of nutritional therapy or functional ingredient aimed at the prevention and treatment of T2DM.

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Foods from Mayan Communities of Yucatán as Nutritional Alternative for Diabetes Prevention

Cited by 7 publications

References 71 publications

Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus

Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus

Combination therapy of bioactive compounds with acarbose: A proposal to control hyperglycemia in type 2 diabetes

Cabbage (Brassica oleracea var. capitata): A food with functional properties aimed to type 2 diabetes prevention and management

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