2022
DOI: 10.1111/jfbc.14268
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Combination therapy of bioactive compounds with acarbose: A proposal to control hyperglycemia in type 2 diabetes

Abstract: Type 2 diabetes (T2D) is a chronic metabolic disease with a high impact on public health and social welfare. Hyperglycemia is a characteristic of T2D that leads to different complications. Acarbose (ACB) reduces hyperglycemia by inhibiting α‐amylase (AMY) and α‐glucosidase (GLU) enzymes. However, ACB causes low adherence to treatment by patients with diabetes due to its side effects. Consequently, reducing the side effects produced by ACB without compromising its efficacy is a challenge in treating T2D. Bioact… Show more

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Cited by 9 publications
(5 citation statements)
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References 110 publications
(138 reference statements)
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“…[ 75 ] Similarly, the efficacy of α‐amylase inhibitory drugs is affected by many factors (adsorption, excretion, mode of action, and metabolism). [ 111 ] Being nanometer‐sized, AgNPs could easily cross the cell barriers (cell membrane) and may exhibit long‐term effects on the biological system. [ 75 ] The current consequences are coherent with prior studies, which suggested that the excellent anti‐α‐amylase potential of Zea mays extract‐mediated AgNPs might be associated with the electrostatic attraction between cells and NPs.…”
Section: Discussionmentioning
confidence: 99%
“…[ 75 ] Similarly, the efficacy of α‐amylase inhibitory drugs is affected by many factors (adsorption, excretion, mode of action, and metabolism). [ 111 ] Being nanometer‐sized, AgNPs could easily cross the cell barriers (cell membrane) and may exhibit long‐term effects on the biological system. [ 75 ] The current consequences are coherent with prior studies, which suggested that the excellent anti‐α‐amylase potential of Zea mays extract‐mediated AgNPs might be associated with the electrostatic attraction between cells and NPs.…”
Section: Discussionmentioning
confidence: 99%
“…In addition to its other effects, inhibiting carbohydrate-hydrolyzing enzymes such as α-amylases and α-glucosidases in the digestive system can help prevent glucose absorption, thereby reducing postprandial hyperglycemia. This is particularly important as postprandial hyperglycemia is a significant component of all forms of diabetes [ 48 ]. Concurrently, intestinal lipase plays an important role in triacylglycerols absorption, which is related to body weight control and obesity [ 49 ].…”
Section: Effects Of Gp On Intestinal Nutrient Digestion and Absorptionmentioning
confidence: 99%
“…Also Shahavandi et al [27] found that adherence to DAQS showed a significant decrease for systolic blood pressure among 270 apparently healthy adults. Emerging new research suggests that designing dietary strategies based on bioactive antioxidants can prevent metabolic disorders [28][29][30]. For this reason, we hypothesized that a higher quality of dietary antioxidant score may be associated with a favorable cardio-metabolic profile such as blood pressure, glycemic markers and lipid profile among adult individuals with obesity who are apparently metabolically healthy from two metropolises of Iran, Tabriz and Tehran.…”
Section: Introductionmentioning
confidence: 99%