Food preservatives sodium benzoate and propionic acid and colorant curcumin suppress Th1-type immune response in vitro

Maier, Elisabeth; Kurz, Katharina; Jenny, M; Schennach, Harald; Ueberall, Florian; Fuchs, Dietmar

doi:10.1016/j.fct.2010.04.042

Cited by 73 publications

(56 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are consistent with our earlier report on the inhibition of IL-12 signaling and neural antigen-specific Th1 differentiation by curcumin in EAE. This is also in agreement with earlier reports on the inhibition of T cell proliferation and IL-17 expression in MBP-reactive lymphocyte [36] and a shift from Th1 to Th2 response in cultured human peripheral blood mononuclear cells [37]. Thus, curcumin inhibits EAE in association with the inhibition of neural antigen-specific Th1 and Th17 cell differentiation.…”

Section: Discussionsupporting

confidence: 92%

Differential regulation of CD4+ T helper cell responses by curcumin in experimental autoimmune encephalomyelitis

Kanakasabai

Casalini

Walline

et al. 2012

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

Differential regulation of CD4+ T helper cell responses by curcumin in experimental autoimmune encephalomyelitis

Kanakasabai

Casalini

Walline

et al. 2012

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

“…These parameters were not changed by propionate or acetate. Other studies, in contrast, showed anti-inflammatory effects of propionate and acetate [50,55,56,57 ].…”

Section: Effects Of Short-chain Fatty Acids Especially Butyrate On mentioning

confidence: 81%

“…Säemann et al [49] suggested that in peripheral lymphocytes and monocytes, butyrate prevents a proinflammatory and T H 1 profile and shifts it to a T H 2 profile, a phenomenon also reported for propionate [57 ]. However, this is conflicting with other data, where, in a LPS-stimulated and phytohemagglutinin-stimulated whole-blood model, the butyrate-induced shift away from a proinflammatory and T H 1 profile did not result in a clear T H 2 profile [58].…”

Section: Effects Of Short-chain Fatty Acids Especially Butyrate On mentioning

confidence: 92%

Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health?

Meijer¹,

Vos

Priebe³

2010

Current Opinion in Clinical Nutrition and Metabolic Care

373

246

View full text Add to dashboard Cite

SCFAs show anti-inflammatory effects and seem to have the potency to prevent infiltration of immune cells from the bloodstream in, for example, the adipose tissue. In addition, their ability to inhibit the proliferation and activation of T cells and to prevent adhesion of antigen-presenting cells could be important as it recently has been shown that obesity-associated inflammation might be antigen-dependent. More studies with concentrations in micromolar range are needed to approach more physiological concentrations.

show abstract

“…Propionate (at concentrations of 2.0 to 5.0 mmol/L) inhibits the proliferation of lymphocytes stimulated by mitogens 50) . Propionate (250 to 500 µ mol/L) suppresses the Th1-type immune response in stimulated human peripheral blood mononuclear cells 51) . Butyrate (1.0 mmol/L) inhibits the proliferation of T lymphocytes, and more than 2.0 mmol/L of butyrate induces apoptosis in activated T lymphocytes, but not primary macrophages 52) .…”

Section: Short Chain Fatty Acids and T Cellsmentioning

confidence: 99%

Are Short Chain Fatty Acids in Gut Microbiota Defensive Players for Inflammation and Atherosclerosis?

Ohira

Tsutsui

Fujioka

2017

JAT

367

244

View full text Add to dashboard Cite

Intestinal flora (microbiota) have recently attracted attention among lipid and carbohydrate metabolism researchers. Microbiota metabolize resistant starches and dietary fibers through fermentation and decomposition, and provide short chain fatty acids (SCFAs) to the host. The major SCFAs acetates, propionate and butyrate, have different production ratios and physiological activities. Several receptors for SCFAs have been identified as the G-protein coupled receptor 41/free fatty acid receptor 3 (GPR41/FFAR3), GPR43/FFAR2, GPR109A, and olfactory receptor 78, which are present in intestinal epithelial cells, immune cells, and adipocytes, despite their expression levels differing between tissues and cell types. Many studies have indicated that SCFAs exhibit a wide range of functions from immune regulation to metabolism in a variety of tissues and organs, and therefore have both a direct and indirect influence on our bodies. This review will focus on SCFAs, especially butyrate, and their effects on various inflammatory mechanisms including atherosclerosis. In the future, SCFAs may provide new insights into understanding the pathophysiology of chronic inflammation, metabolic disorders, and atherosclerosis, and we can expect the development of novel therapeutic strategies for these diseases.

show abstract

Food preservatives sodium benzoate and propionic acid and colorant curcumin suppress Th1-type immune response in vitro

Cited by 73 publications

References 44 publications

Differential regulation of CD4+ T helper cell responses by curcumin in experimental autoimmune encephalomyelitis

Differential regulation of CD4+ T helper cell responses by curcumin in experimental autoimmune encephalomyelitis

Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health?

Are Short Chain Fatty Acids in Gut Microbiota Defensive Players for Inflammation and Atherosclerosis?

Contact Info

Product

Resources

About