Differential regulation of CD4+ T helper cell responses by curcumin in experimental autoimmune encephalomyelitis

Kanakasabai, Saravanan; Casalini, Eli D.; Walline, Crystal C.; Mo, Caiqing; Chearwae, Wanida; Bright, John J.

doi:10.1016/j.jnutbio.2011.10.002

Cited by 73 publications

(55 citation statements)

References 48 publications

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“…Further evidence of curcumin's immuno-modulating effects are demonstrated by its ability to lower Th-17 autoimmune responses (Kanakasabai et al, 2012;Xie et al, 2009) which have recently been shown to be upregulated in major depression . Curcumin also decreases the expression of Th-1 cytokines (e.g., IFN-γ, TNF-α) and increases the expression of Th-2 cytokines (e.g., IL-4 and IL-10) (Bereswill et al, 2010;Zhang et al, 2006).…”

Section: Effects Of Curcumin On Immune Pathways <<mentioning

confidence: 99%

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

2012

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Curcumin is the principal curcuminoid of the popular Indian spice turmeric and has attracted increasing attention for the treatment of a range of conditions. Research into its potential as a treatment for depression is still in its infancy, although several potential antidepressant mechanisms of action have been identified. Research completed to date on the multiple effects of curcumin is reviewed in this paper, with a specific emphasis on the biological systems that are compromised in depression. The antidepressant effects of curcumin in animal models of depression are summarised, and its influence on neurotransmitters such as serotonin and dopamine is detailed. The effects of curcumin in moderating hypothalamus-pituitary-adrenal (HPA) disturbances, lowering inflammation, and protecting against oxidative stress, mitochondrial damage, neuroprogression and intestinal hyperpermeability, all of which are compromised in major depressive disorder, are also summarised. With increasing interest in natural treatments for depression, and efforts to enhance current treatment outcomes, curcumin is presented as a promising novel, adjunctive or stand-alone natural antidepressant.

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Section: Effects Of Curcumin On Immune Pathways <<mentioning

confidence: 99%

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

2012

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“…It has been shown to have a neuroprotective role in EAE [8, 9], but it is unknown whether curcumin is able to protect mitochondria from injury and subsequently suppress apoptosis in the early pathology of MS/EAE.…”

Section: Introductionmentioning

confidence: 99%

Curcumin Inhibits Mitochondrial Injury and Apoptosis from the Early Stage in EAE Mice

Feng

Tao

Yan

et al. 2014

Oxidative Medicine and Cellular Longevity

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The exact pathophysiological change concerning mitochondrial injury and oligodendrocyte apoptosis in MS and EAE model is still unknown. Whether curcumin is able to inhibit mitochondrial injury and suppress the apoptosis in the early stages of MS/EAE is still unclear. We first explored mitochondrial injury and apoptosis at different time points p.i. in C57 BL/6 EAE mice. We then explored the effects of curcumin on mitochondria and apoptosis. Results showed that mitochondrial injury can be observed 3 days p.i. Apoptosis in the spinal cord occurred 3 days p.i. and the apoptotic cells were shown to be oligodendrocytes and neuronal cells. Curcumin significantly reduced the number of apoptotic cells and inhibited the upregulation of cyt-c, caspase-9, and caspase-3 at 7 days p.i. in the EAE mice. These observations demonstrate that mitochondrial injury and oligodendrocyte/neuronal apoptosis occur in the early stages of EAE. Curcumin can inhibit apoptosis in EAE mice which maybe act through protection of mitochondrial injury and inhibition of the intrinsic apoptotic pathway.

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“…18 Major polyphenolic phytochemicals including curcumin have been isolated from the rhizome of the plant Curcuma longa (turmeric) that has been traditionally used for the treatment of inflammation for centuries. 23 Most of these reported phytochemicals in individual plant components have showed their presence in GSTC3. Even though not quantitatively determined, the presence of active principles in the combined formulation suggests the possibility that an additive/synergetic action of these active principles would be exhibited by GSTC3.…”

Section: Discussionmentioning

confidence: 99%

Component Authentication and Standardisation of an Anti-atherosclerotic Herbal Formulation-GSTC3

Manalil¹,

Suseela²,

Ramavarma³

et al. 2015

Phcog J

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Context: Polyherbal drugs in traditional medicine have been time-tested for treatment of a wide variety of chronic ailments. Aims: To determine constituent components in an in-house designed polyherbal formulation GSTC3 and evaluation of consistency in preparation. Settings and Design: In this study, a hypolipidemic formulation was created using well known plant extracts such as Commiphora mukul (Hook. ex Stocks.) Eng. (Burseraceae), Salacia reticulata Wight (Celastraceae), Terminalia arjuna (Roxb.) Wight and Arn (Combretaceae) and Curcuma longa Linn (Zingiberaceae). Methods and Material:The authentication of individual plant powders was performed using techniques such as powder microscopy and characterised according to Ayurvedic pharmacopeia of India. Phytochemical screening, HPTLC analysis and physicochemical parameters were also determined. Results:The powder microscopic analysis of the individual components served as an authentication for source of plants used. Phytochemical screening ascertained that active classes of compounds reported in the individual extracts such as steroids, terpenoids and polyphenols came into the formulation. Finally, HPTLC analysis of three different batches of GSTC3 ensured stability and integrity in batch to batch preparations. Conclusion: Experimental studies have revealed the antioxidant, antiinflammatory, anti-lipidemic and anti-thrombotic efficacy of GSTC3. This standardisation procedure is essential for further development of GSTC3 into an efficient anti-atherosclerotic drug candidate.Key words: HPTLC, Pharmacognosy, Polyherbal formulation, Powder microscopy, Phytochemical screening. SUMMARY• GSTC is an anti-atherosclerotic polyherbal formulation developed from four individual medicinal plants.• Powder microscopic analysis of the individual components of GSTC3 served as an authentication of source plant.• Phytochemical screening ascertained the presence of steroids, terpenoids and polyphenols in the formulation.• HPTLC analysis of three different batches of GSTC3 ensured stability and integrity among batch to batch preparations.• Physicochemical analysis showed the feasibility of GSTC3 in its further development as an efficient anti-atherosclerotic drug candidate.

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Differential regulation of CD4+ T helper cell responses by curcumin in experimental autoimmune encephalomyelitis

Cited by 73 publications

References 48 publications

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

Curcumin Inhibits Mitochondrial Injury and Apoptosis from the Early Stage in EAE Mice

Component Authentication and Standardisation of an Anti-atherosclerotic Herbal Formulation-GSTC3

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