Food-Grade Encapsulation Systems for (−)-Epigallocatechin Gallate

Shi, Meng; Shi, Yun-Long; Li, Xu-Min; Yang, Rui; Cai, Zhuo‐Yu; Li, Qingsheng; Ma, Shicheng; Ye, Jian-Hui; Lu, Jian; Liang, Yue-Rong; Zheng, Xin-Qiang

doi:10.3390/molecules23020445

Cited by 41 publications

(26 citation statements)

References 95 publications

(138 reference statements)

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“…Furthermore, chronic inflammation shows adverse effects for the bone healing 40) . Meanwhile, it is consensual that EGCG is a strong antioxidant and anti-inflammatory agent 8) . Additionally, the presence of EGCG in biomaterials treated by coating or modification approaches alters the materials properties, including wettability, charge, and calcium deposition 18,22) .…”

Section: Discussionmentioning

confidence: 99%

“…Epigallocatechin gallate (EGCG), the most abundant bioactive polyphenolic compound in green tea, is a known health-promoting ingredient with antioxidant, antibacterial, anti-inflammatory, and anti-cancer properties 8) . The molecule potentially has wide-ranging pharmacological effects on cardiac 9) , inflammatory 10) , oncological 11) , and psychiatric diseases 12) .…”

Section: Introductionmentioning

confidence: 99%

“…The molecule potentially has wide-ranging pharmacological effects on cardiac 9) , inflammatory 10) , oncological 11) , and psychiatric diseases 12) . Thus, this polyphenol is thought to be a promising substance with applicability as a drug in nutritional supplements and biomaterials 8,[13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

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Sustained Release of Catechin from Gelatin and Its Effect on Bone Formation in Critical Sized Defects in Rat Calvaria

Honda

Huang

Zhao

et al. 2020

J. Hard Tissue Biology.

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The potential of plant-derived polyphenols in bone tissue engineering has not been fully realized owing to difficulties in maintaining their stability in affected parts. Catechins, such as epigallocatechin gallate (EGCG), are not fully utilized in bone regenerative medicine. Here, we demonstrated that chemical and non-chemical modifications of gelatin with EGCG resulted in distinct bone-forming abilities in critical-sized bone defects (9 mm) in rat calvaria. We prepared two EG-CG-containing gelatin sponges: vacuum-heated gelatin sponges modified chemically with EGCG (AC-vhEGCG-GS) and vacuum-heated gelatin sponges with EGCG (no chemical modification; NC-vhEGCG-GS). Both sponges were characterized using scanning electron microscopy and degradability and EGCG-retention tests. The bone-forming ability of the sponges were estimated using micro-computed tomography and hematoxylin-eosin staining; the quality of newly formed bone (collagen maturation) was determined using picrosirius red staining and polarized microscopy. Both sponges had a spongy and soft texture with macropores ranging 50-150 µm with negligible differences in degradability. The NC-vhEG-CG-GSs released all their EGCG content within 1 h, whereas AC-vhEGCG-GSs retained 75% of the EGCG for up to 24 h. In addition, AC-vhEGCG-GSs resulted in a significantly greater bone formation than NC-vhEGCG-GSs 4 w after implantation, with negligible differences in collagen maturation. These results suggest that the chemical modification of gelatin with EGCG might be a promising strategy to fully utilize the pharmacological effects of EGCG for natural polymer-based sponges. Moreover, the release rate of EGCG from gelatin is possibly a screening parameter affecting the function of EGCG in vivo.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sustained Release of Catechin from Gelatin and Its Effect on Bone Formation in Critical Sized Defects in Rat Calvaria

Honda

Huang

Zhao

et al. 2020

J. Hard Tissue Biology.

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“…There is convincing evidence that this compound has a stronger antioxidant potential than other green tea catechins, and that it is even more effective in ROS scavenging than vitamins C and E (Rice-Evans et al, 1995). EGCG has been also repeatedly shown to exhibit anti-inflammatory, anti-atherogenic and anti-cancer activities (Singh et al, 2011;Shi et al, 2018). The data from epidemiological studies devoted to investigating EGCG are, however, controversial and often conflicting with in vitro findings.…”

Section: Nano-epigallocatechin-3-gallatementioning

confidence: 99%

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Vaiserman

Koliada

Zayachkivska

et al. 2020

Front. Bioeng. Biotechnol.

140

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The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising strategy to combat aging and associated pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such as curcumin, resveratrol, catechins, quercetin are among the most commonly applied natural compounds used as potential modulators of the free radical-induced cellular damages. The therapeutic potential of these compounds is, however, restricted by their low bioavailability related to poor solubility, stability, and absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems have provided many benefits in preclinical research over the conventional preparations, including superior solubility and stability, extended half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress.

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“…In fact, numerous researches revealed that nanoencapsulation system has been one of the prominent nano delivery systems which significantly increases EGCG stability and improves drug release rate, which partially contributes to the increased cellular uptake of EGCG. In another research reported that the chitosanbased nanoparticulate systems have capable to enhance the EGCG bioavailability [87][88][89][90]. Dube et al, 2013, compared the intestinal absorption of free EGCG and nano-EGCG (CSNP) using excised mouse jejunum.…”

Section: Solid Lipid Nanoparticles (Sln)mentioning

confidence: 99%

Green Tea Catechin Loaded Nanodelivery Systems for the Treatment of Pandemic Diseases

Natarajan

Chandran

Vinukonda

et al. 2019

Asian J Pharm Clin Res

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Tea (Camellia sinensis, Family: Theaceae) is one of the extremely consumed beverages around the world, behind to water. The brew tea is the merely food product contains abundant quantity of the catechins. Green tea is the least processed and thus contains rich antioxidant, polyphenols, especially catechin called epigallocatechin-3-gallate (EGCG), which is whispered to be responsible for a wide range of the health benefits. The key to the amazing health benefits that are derived from green tea is that the leaves are steamed which preserves the EGCG compound from being oxidized. However, the other varieties of teas are under go fermentation process, which breaks down the potential EGCG and destroy from its healing properties. In reality, green tea has very extensive history dating back thousands and thousands of years ago. However, the pharmacological efficacy and stability of green tea catchiness are primarily depended on the formulation and way to drink to alleviate the deadly diseases with scientific evidence. Nanotechnology is a vibrantly emerging field especially in the pharmaceutical industry to explore a lot of application. The promising nano-delivery system used to enhance the therapeutic efficacy with a minimal dose, minimize the dose-related toxicity, target delivery, site-specific delivery, and controlled/sustain the delivery application. In recent decades, the application of nanotechnology has been utilized for phytopharmaceutical industry including green tea catechins to maximize the health benefits. In this review, we tried our level best retrieve the value of information on nanodelivery application of green tea catchiness for various devastating diseases.

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Food-Grade Encapsulation Systems for (−)-Epigallocatechin Gallate

Cited by 41 publications

References 95 publications

Sustained Release of Catechin from Gelatin and Its Effect on Bone Formation in Critical Sized Defects in Rat Calvaria

Sustained Release of Catechin from Gelatin and Its Effect on Bone Formation in Critical Sized Defects in Rat Calvaria

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Green Tea Catechin Loaded Nanodelivery Systems for the Treatment of Pandemic Diseases

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