Food Analysis: Present, Future, and Foodomics

Cifuentes, Alejandro

doi:10.5402/2012/801607

Cited by 91 publications

(39 citation statements)

References 174 publications

(176 reference statements)

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“…However, there is not yet a methodology capable of detecting, identifying and quantifying all human metabolites. Combining techniques such as system-based mass spectrometry, nuclear magnetic resonance, gas chromatography and liquid chromatography may be a better approach for global metabolite identification [93]. As with GWAS, many chemicals and metabolites can be tested for and associated with diet and disease [16] through metabolome-wide studies.…”

Section: Omics Technologies In Personalized Nutritionmentioning

confidence: 99%

“…However, variability and differing concentrations of nutrients and bioactive food compounds create limitations in foodomics studies [93]. …”

Section: Omics Technologies In Personalized Nutritionmentioning

confidence: 99%

“…Metabolomic studies can evaluate groups of metabolites related to a specific metabolic pathway or compare modifications in patterns of metabolites in response to environmental stimuli [93] following targeted or untargeted approaches. Thus, metabolomics is considered the end point of human molecular analysis [94] and can assess the body's response to a diet.…”

Section: Omics Technologies In Personalized Nutritionmentioning

confidence: 99%

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Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition

et al. 2016

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Diversity in the genetic profile between individuals and specific ethnic groups affects nutrient requirements, metabolism and response to nutritional and dietary interventions. Indeed, individuals respond differently to lifestyle interventions (diet, physical activity, smoking, etc.). The sequencing of the human genome and subsequent increased knowledge regarding human genetic variation is contributing to the emergence of personalized nutrition. These advances in genetic science are raising numerous questions regarding the mode that precision nutrition can contribute solutions to emerging problems in public health, by reducing the risk and prevalence of nutrition-related diseases. Current views on personalized nutrition encompass omics technologies (nutrigenomics, transcriptomics, epigenomics, foodomics, metabolomics, metagenomics, etc.), functional food development and challenges related to legal and ethical aspects, application in clinical practice, and population scope, in terms of guidelines and epidemiological factors. In this context, precision nutrition can be considered as occurring at three levels: (1) conventional nutrition based on general guidelines for population groups by age, gender and social determinants; (2) individualized nutrition that adds phenotypic information about the person's current nutritional status (e.g. anthropometry, biochemical and metabolic analysis, physical activity, among others), and (3) genotype-directed nutrition based on rare or common gene variation. Research and appropriate translation into medical practice and dietary recommendations must be based on a solid foundation of knowledge derived from studies on nutrigenetics and nutrigenomics. A scientific society, such as the International Society of Nutrigenetics/Nutrigenomics (ISNN), internationally devoted to the study of nutrigenetics/nutrigenomics, can indeed serve the commendable roles of (1) promoting science and favoring scientific communication and (2) permanently working as a ‘clearing house' to prevent disqualifying logical jumps, correct or stop unwarranted claims, and prevent the creation of unwarranted expectations in patients and in the general public. In this statement, we are focusing on the scientific aspects of disciplines covering nutrigenetics and nutrigenomics issues. Genetic screening and the ethical, legal, social and economic aspects will be dealt with in subsequent statements of the Society.

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Section: Omics Technologies In Personalized Nutritionmentioning

confidence: 99%

“…However, variability and differing concentrations of nutrients and bioactive food compounds create limitations in foodomics studies [93]. …”

Section: Omics Technologies In Personalized Nutritionmentioning

confidence: 99%

Section: Omics Technologies In Personalized Nutritionmentioning

confidence: 99%

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Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition

et al. 2016

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“…With ASE, the adverse environmental impact of the conventional reference methods could be reduced in three different ways: reduction of the amount of solvents required; reduction in the amount and the toxicity of solvents and reagents employed in the extraction step, especially by automatization and miniaturization (Stocka et al, 2011). The procedure is highly automated(Kuranchie-Mensah et al, 2013)and it is already especially useful for routine analyses of environmental pollutants and food in many analytical laboratories (GiergielewiczMożajska et al, 2010).It aims to save employee labor and time, while improving the efficiency of the analyte isolation (Cifuentes, 2012) running safe operations without a continuous supervision.…”

Section: Introductionmentioning

confidence: 99%

The Rate of Success of the Accelerated Solvent Extraction (Ase) of Fat and Organochlorine Pesticides from Dried Fish Meat Samples

Cioca¹,

Heemken²,

Mihaiu³

2017

BUASVMCN-VM

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The replacement of conventional sample preparation techniques with newer techniques which are automated, faster and more eco-friendly, is nowadays desired in every analytical laboratory. One of the techniques with the attributes mentioned above is the Accelerated Solvent Extraction. In order to evaluate how successful this method is for the extraction of fat and organochlorine pesticides (OCPs) from dried fish meat samples, we have tested two series of diverse fish using Dionex™ 350 ASE provided by Thermo Scientific™ (Germany). For a more interesting approach, we added to our investigation 7 polychlorinated biphenyl (PCBs), 3 thricholorobenzenes, 2 tetrachlorobenzenes, 1 pentachlorobenzenes and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The study focused on comparing the recoveries of these analytes from different fish samples, after replacing the conventional reference method of the laboratory with ASE. The ASE parameters tested were previously used for the extraction of fat and polybrominated diphenyl ethers (PBDE) from fish samples: temperature: 120 ° C; static time: 5 min; number of cycles: 3; flushing volume: 25%; rinse with nitrogen: 90 s; solvent: cyclohexane/ethyl acetate (ratio 1:1).The ASE method provided similar and in some cases better results when compared to the standard reference method, more rapidly, eco-friendly and safer. Any high or low recoveries of the analytes taken into study are attributed to random or systematic errors during the Clean-up step of the extracts and the quantification with Gas Chromatography coupled with Tandem Mass-Spectrometry (GC MS/MS).

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“…However, an important challenge is to detect untargeted compounds and to determine their identity in foods. Therefore, the development of advanced analytical techniques is expected to play a crucial role [12]. Moreover, in order to establish the MRL-s the European Food Safety Authority (EFSA) take into account that no information regarding the storage stability of pesticides, and their metabolism and residues in crops.…”

Section: Introductionmentioning

confidence: 99%

Identification and quantification of some pesticide metabolites from vegetables by GC-TOF-MS and LC-MS-QQQ

Meghesan-Breja¹,

Cimpoiu²,

Hosu³

2017

Studia UBB Chemia

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ABSTRACT. Considering the international situation regarding the residues of pesticides in vegetables and fruits and the requirement for sensitive and reliable analytical methods that are able to ensure the compliance of marketed food commodities with the law on food safety, the aim of this paper was the identification and determination of some degradation products and metabolites of ten most often used pesticides. Two analytical approaches are proposed and used for the development of reliable screening, quantification and confirmation of pesticides metabolites in different vegetables. The proposed methods have different approaches than the other multi-residue methods for vegetables allowing the extensive investigation of previously undetectable or unknown pesticide metabolites in vegetables. These methods were tested on cherry tomato, cucumber, and chili pepper, some of the most widely consumed vegetables. The results suggests that spraying pesticides in high doses lead to high levels of pesticide residues in the case of some studied vegetables and the concentration of metabolites together concentration of parent pesticide must be taken into account in order to establish the MRL's in vegetables and fruits.

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Food Analysis: Present, Future, and Foodomics

Cited by 91 publications

References 174 publications

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition

The Rate of Success of the Accelerated Solvent Extraction (Ase) of Fat and Organochlorine Pesticides from Dried Fish Meat Samples

Identification and quantification of some pesticide metabolites from vegetables by GC-TOF-MS and LC-MS-QQQ

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