Food allergy to gelatin in children with systemic immediate-type reactions, including anaphylaxis, to vaccines☆☆☆★

Sakaguchi, Masahiro; Nakayama, Tetsuo; Inouye, Sakae

doi:10.1016/s0091-6749(96)80191-6

Cited by 180 publications

(84 citation statements)

References 9 publications

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“…As another possible association between vaccination and food hypersensitivity against beef, sensitization to vaccine components such as BSA might have been developed by beef intake before vaccination, since some dogs were shown to develop allergic reactions after the first vaccination and have high levels of serum IgE directed to components in the vaccines for dogs [8]. Similar clinical association between food hypersensitivity and allergic reactions following vaccination was also reported in humans via gelatin that was included in vaccines as a stabilizer and identified as an IgE-reactive vaccine component [11]. Allergic reactions after vaccination as well as food hypersensitivity are considered important practical issues in dogs [6,9,10]; therefore, the possible relationship between food hypersensitivity against beef and vaccine-related allergic reactions in dogs should be investigated.…”

mentioning

confidence: 75%

Identification of Bovine Serum Albumin as an IgE-Reactive Beef Component in a Dog with Food Hypersensitivity against Beef

Ohmori

Masuda²,

Kawarai

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. IgE-reactive beef components were examined by an immunoblot analysis using a serum from a dog with food hypersensitivity against beef. The immunoblot analysis revealed a distinct band at approximately 66 kDa and a faint band at approximately 50 kDa. The immunoblot analysis for serum IgE reactivity to bovine serum albumin (BSA) also revealed a positive band at 66 kDa. Serum IgE reactivity to the 66-kDa protein of beef was diminished by pre-incubating the serum sample with BSA. Furthermore, a positive reaction to BSA was detected in intradermal testing in the dog. These results clearly indicated that BSA was an IgE-reactive beef component in the dog with food hypersensitivity against beef. KEY WORDS: allergy, beef, IgE.J. Vet. Med. Sci. 69(8): 865-867, 2007 Food hypersensitivity induces nonseasonal pruritic skin diseases and gastrointestinal signs such as diarrhea and vomiting in dogs. Food ingredients such as beef, cow's milk, soy, corn, wheat, chicken, and chicken eggs have been reported to cause food hypersensitivity in dogs [1,3]. In the two previous reports, 60% and 73% of dogs with food hypersensitivity were shown to develop their clinical sings after oral provocation of beef, respectively [1,3]. Thus, beef can be considered as one of the common food ingredients associated with food hypersensitivity in dogs.Previous studies reported positive results in antigen-specific serum IgE measurement, intradermal testing (IDT), and antigen-specific histamine release assay to food antigens in dogs with food hypersensitivity [1][2][3], indicating that clinical manifestations of food hypersensitivity can be mediated by type I hypersensitivity in dogs that have IgE directed to food antigens in their sera. However, the antigen recognition by IgE has not been well characterized. Identification of allergenic components of food is essential for elucidating the immunological mechanism and developing diagnostic tools for canine food hypersensitivity. Therefore, in the present study, we investigated beef components recognized by serum IgE in a dog with food hypersensitivity against beef by using an immunoblot analysis.A 10-year-old female beagle that showed pruritus and erythema associated with food intake was diagnosed with food hypersensitivity against beef. The diagnosis in the dog was based on the results of a food elimination trial using a commercially available hypoallergenic diet (Prescription Diet Canine z/d ULTRA Allergen Free, Hill's Pet Products, Topeka, KS) and the following food challenge testing using beef conducted as described previously [1,2]. This dog was shown to have a high level of serum IgE directed to beef [46 laboratory units (LU)] by commercially available antigenspecific dog IgE tests (Topscreen and Immunodot tests, CMG Laboratories, Fribourg, Switzerland). In the healthy control dogs, levels of serum IgE directed to beef were 0 LU.Crude beef proteins were extracted from raw beef. In brief, ground raw beef was homogenized thoroughly in phosphate buffered saline (PBS) at 4°C, and then centri...

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mentioning

confidence: 75%

Identification of Bovine Serum Albumin as an IgE-Reactive Beef Component in a Dog with Food Hypersensitivity against Beef

Ohmori

Masuda²,

Kawarai

et al. 2007

The Journal of Veterinary Medical Science

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“…Anaphylaxis to gelatine in condiments (146,147) and, at least in some countries, vaccines has been increasingly recognized (148)(149)(150). It seems obvious to avoid gelatinebased colloids in patients with known gelatine allergy (147).…”

Section: Plasma Volume Expanders (Colloids)mentioning

confidence: 99%

Anaphylaxis during anaesthesia: diagnostic approach

Ebo¹,

Fisher²,

Hagendorens³

et al. 2007

Allergy

190

197

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Anaesthesiologists administer several drugs while providing general anaesthesia. Many of these drugs can elicit adverse drug reactions that fall apart into two major types. First, reactions that are usually dose-dependent and related to the pharmacological properties of the drug and/or its metabolites. Second, reactions that are unrelated to the drug's pharmacological characteristics and that are less dose-dependent. These reactions comprise drug intolerance, idiosyncratic reactions and drug-induced immune-mediated allergic and nonimmune-mediated so-called pseudo-allergic or anaphylactoid reactions. The terms anaphylactic and anaphylactoid, however, have been used inconsistently in the literature. Therefore, the nomenclature task force set up by the European Academy of Allergy and Immunology (EAACI) has proposed that anaphylactic-type reactions should be reclassified into allergic anaphylaxis and nonallergic anaphylaxis. Allergic anaphylaxis being further subdivided in IgE-mediated and non-IgE-mediated reactions (1).The exact prevalence of anaphylaxis during anaesthesia is difficult to ascertain. The estimated overall frequency has been reported to vary between 1 in 3500 and 1 in 13 000 procedures in French series (2, 3) and between 1 in 10 000 and 1 in 20 000 in an Australian study (4). The clinical manifestation of these reactions is not infrequently an almost immediate generalized response with bronchospasm and hypotension. The degree of severity varies and does not allow differentiation between an IgE-mediated or non-IgE mediated reaction resulting from nonspecific mediator release (5). The mortality from these reactions is in the range from 3 to 6%, and an additional 2% of patients experience significant residual brain damage (4).Diagnosis of anaphylaxis during anaesthesia is not always straightforward. It can be hampered as a broad spectrum of different drugs can elicit heterogeneous allergic and nonallergic reactions with distinct and sometimes unclear pathological mechanisms. Problems are certainly compounded as multiple drugs need to be administered during general anaesthesia. In addition, nonanaesthesia related drugs or procedures (e.g. disinfection) are sometimes administered/performed in the perioperative period and can also be the cause of an allergic reaction.In addition, none of the available diagnostic tests demonstrates absolute accuracy. False-positive test Correct management of anaphylaxis during anaesthesia requires a multidisciplinary approach with prompt recognition and treatment of the acute event by the attending anaesthesiologist, and subsequent determination of the responsible agent(s) with strict avoidance of subsequent administration of all incriminated and/or cross-reacting compounds.However, correct identification of the causative compound(s) and safe alternatives is not always straightforward and, too often, not done.This review is not intended to discuss acute management of anaesthesia-related anaphylaxis but summarizes the major causes of anaphylaxis during anaesthesia and the di...

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“…Post-vaccination allergic reactions to MMR and varicella vaccines have been linked to the gelatin excipient, and confirmed through observation of induced gelatinspecific IgE antibodies [97][98][99][100]. 24 out of 26 children with allergic reactions to vaccines (e.g., anaphylactic shock) had anti-gelatin IgE ranging from 1.2 to 250 μg/mL.…”

Section: Evidence For a Role For Collagen In Vaccine Adverse Reactionsmentioning

confidence: 80%

“…Seven were allergic to gelatin-containing foods. A pool of 26 control children all tested negative for anti-gelatin IgE [99]. A study from 2009 that looked at gelatin sensitivity in children who were sensitive to cows' milk, beef and/or pork as determined by IgE antibody levels [101] found that 16% of beef-sensitized children and 38% of porksensitized children had IgE antibodies to beef-or porkderived gelatins that were cross-reactive with each other.…”

Section: Evidence For a Role For Collagen In Vaccine Adverse Reactionsmentioning

confidence: 99%

Glyphosate pathways to modern diseases VI: Prions, amyloidoses and autoimmune neurological diseases

Samsel¹,

Seneff²

2017

JBPC

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Food allergy to gelatin in children with systemic immediate-type reactions, including anaphylaxis, to vaccines☆☆☆★

Cited by 180 publications

References 9 publications

Identification of Bovine Serum Albumin as an IgE-Reactive Beef Component in a Dog with Food Hypersensitivity against Beef

Identification of Bovine Serum Albumin as an IgE-Reactive Beef Component in a Dog with Food Hypersensitivity against Beef

Anaphylaxis during anaesthesia: diagnostic approach

Glyphosate pathways to modern diseases VI: Prions, amyloidoses and autoimmune neurological diseases

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