We describe a patient with adventitial cystic disease of the popliteal artery with intermittent claudication involving the right calf during exercise. Magnetic resonance imaging (MRI) and computed tomography (CT) revealed a cystic lesion that encircled and compressed the popliteal artery. Resection of the cyst involving a segment of the affected popliteal artery and interposing an autologous vein graft resolved the symptoms, and the postoperative course was uneventful. The cyst was histologically similar to a ganglion.

ABSTRACT. IgE-reactive beef components were examined by an immunoblot analysis using a serum from a dog with food hypersensitivity against beef. The immunoblot analysis revealed a distinct band at approximately 66 kDa and a faint band at approximately 50 kDa. The immunoblot analysis for serum IgE reactivity to bovine serum albumin (BSA) also revealed a positive band at 66 kDa. Serum IgE reactivity to the 66-kDa protein of beef was diminished by pre-incubating the serum sample with BSA. Furthermore, a positive reaction to BSA was detected in intradermal testing in the dog. These results clearly indicated that BSA was an IgE-reactive beef component in the dog with food hypersensitivity against beef. KEY WORDS: allergy, beef, IgE.J. Vet. Med. Sci. 69(8): 865-867, 2007 Food hypersensitivity induces nonseasonal pruritic skin diseases and gastrointestinal signs such as diarrhea and vomiting in dogs. Food ingredients such as beef, cow's milk, soy, corn, wheat, chicken, and chicken eggs have been reported to cause food hypersensitivity in dogs [1,3]. In the two previous reports, 60% and 73% of dogs with food hypersensitivity were shown to develop their clinical sings after oral provocation of beef, respectively [1,3]. Thus, beef can be considered as one of the common food ingredients associated with food hypersensitivity in dogs.Previous studies reported positive results in antigen-specific serum IgE measurement, intradermal testing (IDT), and antigen-specific histamine release assay to food antigens in dogs with food hypersensitivity [1][2][3], indicating that clinical manifestations of food hypersensitivity can be mediated by type I hypersensitivity in dogs that have IgE directed to food antigens in their sera. However, the antigen recognition by IgE has not been well characterized. Identification of allergenic components of food is essential for elucidating the immunological mechanism and developing diagnostic tools for canine food hypersensitivity. Therefore, in the present study, we investigated beef components recognized by serum IgE in a dog with food hypersensitivity against beef by using an immunoblot analysis.A 10-year-old female beagle that showed pruritus and erythema associated with food intake was diagnosed with food hypersensitivity against beef. The diagnosis in the dog was based on the results of a food elimination trial using a commercially available hypoallergenic diet (Prescription Diet Canine z/d ULTRA Allergen Free, Hill's Pet Products, Topeka, KS) and the following food challenge testing using beef conducted as described previously [1,2]. This dog was shown to have a high level of serum IgE directed to beef [46 laboratory units (LU)] by commercially available antigenspecific dog IgE tests (Topscreen and Immunodot tests, CMG Laboratories, Fribourg, Switzerland). In the healthy control dogs, levels of serum IgE directed to beef were 0 LU.Crude beef proteins were extracted from raw beef. In brief, ground raw beef was homogenized thoroughly in phosphate buffered saline (PBS) at 4°C, and then centri...

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In veterinary medicine, the management of malignant skin wounds is highly challenging. We conducted a study on seven case animals (four dogs and three cats) which presented with malignant skin wounds. All seven animals had signs and symptoms which were controlled following treatment with a modified Mohs paste. Upon obtaining informed consent from their owners, the animals requiring management of malignant wounds were enrolled in this study. The modified Mohs paste was prepared by mixing zinc chloride, zinc oxide starch powder, glycerin, and distilled water. The modified Mohs paste was topically applied to and left to remain on the malignant wounds for one hour, under controlled conditions. Once the paste was removed, the wounds were irrigated with a solution of sterile saline. At the first examination, the wounds of each animal were observed for signs of exudate, malodor, and bleeding. In every case, visible improvement was observed immediately after the modified Mohs paste treatment. Specifically, the size of the malignant wounds, and the number of times the dressing gauze required changing, significantly decreased (p < 0.05 and p < 0.01, respectively). The open malignant skin wounds caused by mammary gland tumors disappeared in two cases. The Mohs paste has been shown to be a viable option for the palliative treatment in canine and feline malignant skin wound management.

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