Follicle-Stimulating Hormone Activates a cAMP-Dependent Chloride Conductance in TM4 Sertoli Cells

Jungwirth, A.; Weiger, Thomas; Singh, Shio Kumar; Paulmichl, Markus; Frick, J.

doi:10.1006/bbrc.1997.6424

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…However, in another report it was shown that SK11 cells as well as SK9 cells do not bind to spermatids in vitro , 49 rendering both cell lines unsuitable for studies on the impact of steroids on spermatogenesis, and other aspects of Sertoli cell–germ‐cell interactions. In agreement with that, other frequently used murine Sertoli cell lines, such as the TM4 line, 50 which has been shown to be FSH responsive, 51 and the SF7 line, were shown to be unable to maintain spermatogonial stem cells in coculture experiments 52 …”

Section: Sertoli Cell Maturation Is Required For the Initiation Of Spsupporting

confidence: 83%

Testicular Morphogenesis

Gassei

Schlatt

2007

Annals of the New York Academy of Sciences

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The organogenesis of a functional testis is the basis for male fertility and perpetuation of each species. In mammals, testicular development is dependent on two crucial events during embryonic and pubertal development. First, primary sex determination is initiated by expression of the Sry gene on the Y chromosome and directs the primordial gonad toward testicular development rather than ovarian differentiation. The male pathway comprises highly regulated cell differentiation of somatic cells within the gonadal primordium, as well as migration of mesonephric cells and primordial germ cells, ultimately leading to the formation of testis cords. These cords present the earliest visible sign of male gonadal differentiation. Second, during puberty immature Sertoli cells cease to proliferate and differentiate into their postmitotic, adult phenotype. The maturation of the Sertoli cells is pivotal for initiation and maintenance of spermatogenesis. The regulation of the two separate functions of Sertoli cells—during testis development and in spermatogenesis—are poorly understood. In this review, different models that have been used to study embryonic gonadal development and testicular maturation are compared. In vivo models, organ, and cell culture systems are discussed as regards their applicability to study testicular organogenesis. Then, a new tissue engineering approach is presented that mimics male embryonic gonadogenesis and that offers novel ways to study early testicular differentiation, as well as Sertoli cell maturation and spermatogonial stem‐cell niche formation.

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Section: Sertoli Cell Maturation Is Required For the Initiation Of Spsupporting

confidence: 83%

Testicular Morphogenesis

Gassei

Schlatt

2007

Annals of the New York Academy of Sciences

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“…The exocytosis has been associated with increased intracellular ion concentrations mainly Ca 2+ and Cl − (Jungwirth et al, 1997;Lalevee et al, 1997). It has been shown that 1,25D 3 has a regulatory effect on Cl − currents (Menegaz et al, 2010a) and consequently on cellular secretion, as it was observed when TM4 cells were incubated with the hormone in the presence of quinacrine (Menegaz et al, 2010a).…”

Section: 25d 3 Actions On Testismentioning

confidence: 97%

Nongenomic and genomic effects of 1α,25(OH)2 vitamin D3 in rat testis

et al. 2011

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“…Secretory activities of Sertoli cells are critical to spermatogenesis [18]. Sertoli cells express a variety of ion channels involved in cellular secretory functions [19][20][21][22]. The hormonal regulation of fluid secretion by Sertoli cells is important in male reproduction, and involves multiple signaling pathways including second messengers and modulation of ion channel activities [23,24].…”

Section: Introductionmentioning

confidence: 99%