Folic acid modified cell membrane capsules encapsulating doxorubicin and indocyanine green for highly effective combinational therapy in vivo

Xiao, Li; Zhao, Xiaohuan; Pardhi, Dinesh M.; Wu, Qianqian; Zheng, Yong; Zhu, Huihui; Mao, Zhengwei

doi:10.1016/j.actbio.2018.05.006

Cited by 42 publications

(23 citation statements)

References 47 publications

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“…Encouragingly, combined chemo-photothermal therapy realized successful suppression of MCF-7 and DOX-resistant MCF-7/ADR tumor growth as well as prevention of tumor recurrence in vivo . Similarly, many other attempts have been made to co-encapsulate various NIR dyes and drugs in different kinds of nano-carriers like liposomes (Li et al, 2015; Feng et al, 2016; Yan et al, 2016; Gao et al, 2018; Mu et al, 2019), polymeric nanoparticles (Su et al, 2015; Zhu et al, 2015; Chen Y. et al, 2017; Wang et al, 2017; Deng et al, 2018; He H. Z. et al, 2018; Yao et al, 2018; Tan et al, 2019; Zhang et al, 2019), protein nanoparticles (Chen et al, 2015; Lin and Shieh, 2018; Gao et al, 2019; Pei et al, 2019), and cell membranes (Sun et al, 2015; Li X. et al, 2018; Wan et al, 2018; Zhang N. et al, 2018; Ye et al, 2019). For example, Liu et al developed “Abraxane-like” nanodrug through self-assembly of human serum albumin (HSA), paclitaxel (PTX), and ICG in a simple mixing manner (Chen et al, 2015).…”

Section: Organic Nanomaterials-based Chemo-photothermal Therapymentioning

confidence: 99%

Recent Advances in Nanomaterials-Based Chemo-Photothermal Combination Therapy for Improving Cancer Treatment

Chen

Yang

et al. 2019

Front. Bioeng. Biotechnol.

106

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Conventional chemotherapy for cancer treatment is usually compromised by shortcomings such as insufficient therapeutic outcome and undesired side effects. The past decade has witnessed the rapid development of combination therapy by integrating chemotherapy with hyperthermia for enhanced therapeutic efficacy. Near-infrared (NIR) light-mediated photothermal therapy, which has advantages such as great capacity of heat ablation and minimally invasive manner, has emerged as a powerful approach for cancer treatment. A variety of nanomaterials absorbing NIR light to generate heat have been developed to simultaneously act as carriers for chemotherapeutic drugs, contributing as heat trigger for drug release and/or inducing hyperthermia for synergistic effects. This review aims to summarize the recent development of advanced nanomaterials in chemo-photothermal combination therapy, including metal-, carbon-based nanomaterials and particularly organic nanomaterials. The potential challenges and perspectives for the future development of nanomaterials-based chemo-photothermal therapy were also discussed.

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Section: Organic Nanomaterials-based Chemo-photothermal Therapymentioning

confidence: 99%

Recent Advances in Nanomaterials-Based Chemo-Photothermal Combination Therapy for Improving Cancer Treatment

Chen

Yang

et al. 2019

Front. Bioeng. Biotechnol.

106

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“…Cellular membranes (CM) were reported to be involved in many vital biological processes, which mainly ascribed to the proteins in the phospholipid bilayer 24. In addition, the CM also shows high biocompatibility and inherits the merits of the source cells 25.…”

Section: Introductionmentioning

confidence: 99%

<p>Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer</p>

Yang¹,

Teng²,

Fu³

et al. 2019

IJN

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Background: Photodynamic therapy (PDT) is widely recognized as a promising way to cure cancer. However, the limited tumor homing property of currently available drug delivery systems (DDSs) is the bottleneck for the delivery of photodynamic agents. Purpose: In our study, we decorated silica nanoparticles (SLN) with cell membrane (CM) derived from SGC7901 cells to construct carrier (CM/SLN) which was able to to specifically target the homogenous SGC7901 cells. Materials and methods: Furthermore, the decent drug loading capability of CM/SLN was adopted to load photodynamic agent chlorins e6 (Ce6) to finally construct aDDS suitable for tumor-targeted PDT of gastric cancer. Results: The experimental results suggested that CM/SLN/Ce6 was nano-sized particles with good dispersion and stability in physiological conditions. Moreover, due to the modification of CM,CM/SLN/Ce6 could specifically target the homogenous SGC7901 cells both in vitro and in vivo. Most importantly, further in vivo results demonstrated that the CM/SLN/Ce6 showed a better anticancer outcome compared to SLN/Ce6. Conclusion: CM/SLN/Ce6 might be a promising platform for effective tumor targeted PDT of gastric cancer.

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“…A high cellular uptake of drugs can result in effective treatment efficacy. It has been reported that folate receptors (FAR) are overexpressed in various cancers, including cervical cancer, breast cancer, brain cancer, and colon cancer [ 27 ]. However, A549 cells were usually used as folate receptor-negative control cells [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

Delivery of Doxorubicin for Human Cervical Carcinoma Targeting Therapy by Folic Acid-Modified Selenium Nanoparticles

Xia

Zhao

et al. 2018

IJMS

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Cancer-specific drug delivery represents an attractive approach to preventing undesirable side effects and increasing the accumulation of the drug in tumors. The surface modification of selenium nanoparticles (SeNPs) with targeting moieties thus represents an effective strategy for cancer therapy. In this study, SeNPs were modified with folic acid (FA), whose receptors were overexpressed on the surface of cancer cells, including human cervical carcinoma HeLa cells, to fabricate tumor-targeting delivery carrier FA-SeNPs nanoparticles. Then, the anticancer drug doxorubicin (DOX) was loaded onto the surface of the FA-SeNPs for improving the antitumor efficacy of DOX in human cervical carcinoma therapy. The chemical structure characterization of FA-Se@DOX showed that DOX was successfully loaded to the surface of FA-SeNPs to prepare FA-Se@DOX nanoparticles. FA-Se@DOX exhibited significant cellular uptake in human cervical carcinoma HeLa cells (folate receptor overexpressing cells) in comparison with lung cancer A549 cells (folate receptor deficiency cells), and entered HeLa cells mainly by the clathrin-mediated endocytosis pathway. Compared to free DOX or Se@DOX at the equivalent dose of DOX, FA-Se@DOX showed obvious activity to inhibit HeLa cells’ proliferation and induce the apoptosis of HeLa cells. More importantly, FA-Se@DOX could specifically accumulate in the tumor site, which contributed to the significant antitumor efficacy of FA-Se@DOX in vivo. Taken together, FA-Se@DOX may be one novel promising drug candidate for human cervical carcinoma therapy.

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Folic acid modified cell membrane capsules encapsulating doxorubicin and indocyanine green for highly effective combinational therapy in vivo

Cited by 42 publications

References 47 publications

Recent Advances in Nanomaterials-Based Chemo-Photothermal Combination Therapy for Improving Cancer Treatment

Recent Advances in Nanomaterials-Based Chemo-Photothermal Combination Therapy for Improving Cancer Treatment

<p>Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer</p>

Delivery of Doxorubicin for Human Cervical Carcinoma Targeting Therapy by Folic Acid-Modified Selenium Nanoparticles

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