<p>Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer</p>

Abstract

Background: Photodynamic therapy (PDT) is widely recognized as a promising way to cure cancer. However, the limited tumor homing property of currently available drug delivery systems (DDSs) is the bottleneck for the delivery of photodynamic agents. Purpose: In our study, we decorated silica nanoparticles (SLN) with cell membrane (CM) derived from SGC7901 cells to construct carrier (CM/SLN) which was able to to specifically target the homogenous SGC7901 cells. Materials and methods: Furthermore, the decent drug loading capability of CM/SLN was adopted to load photodynamic agent chlorins e6 (Ce6) to finally construct aDDS suitable for tumor-targeted PDT of gastric cancer. Results: The experimental results suggested that CM/SLN/Ce6 was nano-sized particles with good dispersion and stability in physiological conditions. Moreover, due to the modification of CM,CM/SLN/Ce6 could specifically target the homogenous SGC7901 cells both in vitro and in vivo. Most importantly, further in vivo results demonstrated that the CM/SLN/Ce6 showed a better anticancer outcome compared to SLN/Ce6. Conclusion: CM/SLN/Ce6 might be a promising platform for effective tumor targeted PDT of gastric cancer.

Biomimetic Nanoparticles Camouflaged in Cancer Cell Membranes and Their Applications in Cancer Theranostics

“…The polymer cores with their payloads are usually prepared via nano-precipitation followed by emulsion solvent evaporation, or self-assembly methods. Inorganic core materials used for CCMCNPs include silicon/silica (18,30,32), magnetic materials FIGURE 1 | Schematic illustration of the steps required in the synthesis of CCMCNPs. The schematic was produced, in part, by using the graphics from powerpoint, ChemBioDraw and Servier Medical Art image data bank (https://smart.servier.com).…”

“…The RBC membrane was found to act as a nanosponge for toxins, and bestowed a longer circulation pharmacokinetic profile than uncoated NPs (3). Since this initial study, cell membrane coating technology has significantly expanded to the use of membranes from platelets (4)(5)(6)(7)(8) and from nucleated cells, such as macrophages (9)(10)(11)(12), neutrophils (13), beta cells (14), and cancer cells (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). The use of cancer cell plasma membranes has attracted attention because these membranes carry tumor-specific receptors and antigens that play a role in cancer cell proliferation, invasion, and metastasis.…”

Cell Membrane-Camouflaged Nanocarriers for Cancer Diagnostic and Therapeutic

“…CM/ SLN/Ce6 exhibited excellent stability in physiological conditions and homologous targeting ability. The aforementioned features make CM/SLN/Ce6 a promising cancer-targeting PDT platform (Yang et al, 2019).…”

Biomimetic cancer cell membrane-coated nanosystems as next-generation cancer therapies

“…The cancer-homing features conveyed by CCMs can also benefit the intracellular uptake of photosensitizers, and therefore expand their ROS-mediated cytotoxicity to cancer cells upon light irradiation. As an example, gastric CCM (SGC7901 cell) has been demonstrated to improve the cancer photodynamic therapy of silica nanoparticles loaded with chlorin e6 [10].…”