Biomimetic Nanoparticles Camouflaged in Cancer Cell Membranes and Their Applications in Cancer Theranostics

Jin, Jiefu; Bhujwalla, Zaver M.

doi:10.3389/fonc.2019.01560

Cited by 85 publications

(70 citation statements)

References 59 publications

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“…The major applications for which these particles are used in cancer are homologous targeting to deliver imaging and therapeutic agents, the disruption of cancer cell–stromal cell interactions, and the induction of an immune response. However, some challenges and issues need to be solved before translating this therapeutic approach for use in humans [ 143 ]. Furthermore, quantum dots obtained through microfluidic methods are capable of diagnosing and delivering molecules to cancer cells in vivo.…”

Section: Applications Of Microfluidic Devicesmentioning

confidence: 99%

Fabrication and Applications of Microfluidic Devices: A Review

Niculescu

Chircov

Bîrcă

et al. 2021

IJMS

350

208

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Microfluidics is a relatively newly emerged field based on the combined principles of physics, chemistry, biology, fluid dynamics, microelectronics, and material science. Various materials can be processed into miniaturized chips containing channels and chambers in the microscale range. A diverse repertoire of methods can be chosen to manufacture such platforms of desired size, shape, and geometry. Whether they are used alone or in combination with other devices, microfluidic chips can be employed in nanoparticle preparation, drug encapsulation, delivery, and targeting, cell analysis, diagnosis, and cell culture. This paper presents microfluidic technology in terms of the available platform materials and fabrication techniques, also focusing on the biomedical applications of these remarkable devices.

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Section: Applications Of Microfluidic Devicesmentioning

confidence: 99%

Fabrication and Applications of Microfluidic Devices: A Review

Niculescu

Chircov

Bîrcă

et al. 2021

IJMS

350

208

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show abstract

“…Each type of tumor cell was incubated in culture dishes (20 mm) for 12 h. The cells were incubated with DiI-CCM-(PTX)NS for 0.5 h. The cell samples were washed 3 times with PBS for 5 min and fixed with 4% polyformaldehyde for 20 min. Then, the cells were stained with Hoechst 33258 for 20 min [ 13 , 32 , 33 , 39 ]. Finally, the cells were observed by CLSM.…”

Section: Methodsmentioning

confidence: 99%

Carrier-free highly drug-loaded biomimetic nanosuspensions encapsulated by cancer cell membrane based on homology and active targeting for the treatment of glioma

Fan

Cui²,

Hao³

et al. 2021

Bioactive Materials

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Nanosuspensions, as a new drug delivery system for insoluble drugs, are only composed of a drug and a small amount of stabilizer, which is dispersed in an aqueous solution with high drug-loading, small particle size, high dispersion, and large specific surface area. It can significantly improve the dissolution, bioavailability, and efficacy of insoluble drugs. In this study, paclitaxel nanosuspensions ((PTX)NS) were prepared by an ultrasonic precipitation method, with the characteristics of simple preparation and easy repetition. With the help of a homologous targeting mechanism, a kind of glioma C6 cancer cell membrane (CCM)-coated (PTX)NS was developed and modified with D WSW peptide to obtain D WSW-CCM-(PTX)NS with the functions of BBB penetration and tumor targeting. The results showed that the cancer cell membrane could effectively camouflage the nanosuspensions so that it was not cleared by the immune system and could cross the blood-brain-barrier (BBB) and selectively target tumor tissues. Cell uptake experiments and in vivo imaging confirmed that the uptake of D WSW-CCM-(PTX)NS by tumor cells and the distribution in intracranial gliomas increased. Cytotoxicity test and in vivo anti-glioma studies showed that D WSW-CCM-(PTX)NS could significantly inhibit the growth of glioma cells and significantly prolong the survival time of glioma-bearing mice. Finally, the cancer cell membrane coating endowed the nanosuspensions with the biological properties of homologous adhesion and immune escape. This study provides an integrated solution for improving the targeting of nanosuspensions and demonstrates the encouraging potential of biomimetic nanosuspensions applicable to tumor therapy.

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“…Additionally, membranes from these cells usually need to be purified through a discontinuous sucrose gradient centrifugation to remove the nucleus and other intracellular biomacromolecules. [50,51] Then, the resulting membranes are washed with isoionic buffers and extruded through polycar bonate porous membranes, forming cell membranederived vesicles. - [46] a)…”

Section: Isolation Of Cell Membrane-derived Vesiclesmentioning

confidence: 99%

Improving Cancer Immunotherapy by Cell Membrane‐Camouflaged Nanoparticles

Zeng

2020

Adv Funct Materials

137

103

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Cancer immunotherapy has received tremendous attention in the past decade owing to its clinical successes with the use of immune-checkpoint inhibition and chimeric antigen receptor T cell therapy. However, only a small proportion of the patients have benefited from these immunotherapeutic drugs, which has raised concerns about the low response rate and immune-related adverse events. Nanomedicines have served as a paradigm for preferential tumor accumulation but still confront issues such as poor circulation and insufficient tumor accumulation. By virtue of coating nanoparticles with cell membranes from diverse cell sources, active proteins on cell membranes can impart a variety of desired functionalities or supplementary therapeutic effects to nanoparticles, providing ways for enhanced cancer immunotherapy. In this review, the recent advances of cell membrane camouflaged nanoparticles applied to the improved immunotherapy are discussed on the basis of different sources of cell membranes and corresponding working mechanisms. These biomimetic nanoparticles can potentially deliver therapeutic agents to the designated sites and actively engage in particular stages of the cancer immunity cycle, eliciting antitumor immunity with less off-target toxicities.

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Biomimetic Nanoparticles Camouflaged in Cancer Cell Membranes and Their Applications in Cancer Theranostics

Cited by 85 publications

References 59 publications

Fabrication and Applications of Microfluidic Devices: A Review

Fabrication and Applications of Microfluidic Devices: A Review

Carrier-free highly drug-loaded biomimetic nanosuspensions encapsulated by cancer cell membrane based on homology and active targeting for the treatment of glioma

Improving Cancer Immunotherapy by Cell Membrane‐Camouflaged Nanoparticles

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