Folic acid–egg white coated IPN network of carboxymethyl cellulose and egg white nanoparticles for treating breast cancer

Raj, V.; Priya, P. Gomathi; Rajendran, Renji; Suryamathi, Mathiazhagan; Kalaivani, Sathasivam

doi:10.1007/s13726-018-0647-0

Cited by 8 publications

(8 citation statements)

References 39 publications

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“…This composite is capable of delivering cyclophosphamide and can be a potential candidate for targeted breast cancer drug delivery. It was observed at pH 5.0 and 6.0 that more drug was released than at pH 7.4, which is an ideal feature for drug delivery targeting breast tumors 95 . The anti‐oxidant activity of curcumin can be effectively protected in nanoparticles encapsulated with egg white.…”

Section: Application To Biomaterialsmentioning

confidence: 99%

“…It was observed at pH 5.0 and 6.0 that more drug was released than at pH 7.4, which is an ideal feature for drug delivery targeting breast tumors. 95 The anti-oxidant activity of curcumin can be effectively protected in nanoparticles encapsulated with egg white. Ethanol can lead to an increase in the β-sheet structure of egg white, and a thicker gel structure can be formed during thermal denaturation, leading to an increase in particle diameter.…”

Section: Drug Delivery Systemmentioning

confidence: 99%

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An insight on egg white: From most common functional food to biomaterial application

Dong

Zhang

2020

J Biomed Mater Res

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Natural egg white tis widely used as an ingredient in nutritional foods and for food processing. Due to its characteristic foaming, emulsification, adhesion, and gelation, and its heat setting, biocompatibility, and low cost, research into the application and development of egg white in biomaterials, especially medical biomaterials, have been receiving attention. The composition and characteristics of egg white protein, and the physical mixing and chemically cross‐linking of egg white with other materials used to make degradable packaging films, bioceramics, bioplastics, biomimetic films, hydrogels, 3D scaffolds, bone regeneration, biopatterning, biosensors, and so forth, are reviewed in detail in this report. The novel egg white‐based biomaterials in various forms and applications could be constructed mostly through physical treatments such as ultrasonic wave, ultraviolet, laser and other radiation or high‐temperature calcination. Furthermore, the application and prospects for the use of egg white in biomaterials is also discussed.

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Section: Application To Biomaterialsmentioning

confidence: 99%

Section: Drug Delivery Systemmentioning

confidence: 99%

An insight on egg white: From most common functional food to biomaterial application

Dong

Zhang

2020

J Biomed Mater Res

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“…This gel was utilized to treat breast cancer. Releasing cyclophosphamide from folic acid/egg white cyclophosphamide (IPN-NPs) showed a fast release and pH sensitivity pH 5 and 6 [112]. Poly(vinyl alcohol) was blended with poly(acrylic acid) to produce IPN hydrogels.…”

Section: Drug Delivery Applicationsmentioning

confidence: 99%

Interpenetrating polymeric hydrogels as favorable materials for hygienic applications

2020

Biointerface Res Appl Chem

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Polymers can crosslink to produce intermingled materials with three-dimensional network structure known as interpenetrating polymeric network (IPN). They comprise elastic crosslinked polymeric chains. The chains of the hydrogels are either physically or chemically entangled together. Interpenetrating hydrogels can be tailored to provide enhanced materials. They can be classified according to methods of their synthesis as simultaneous or sequential IPNs and the structure to be homo or semi IPNs. The preparation factors play a role in controlling the properties of the produced IPNs. Moreover, the ambient conditions such as pH, temperature as well as the ionic strength may affect the performance of these hydrogels. The swelling capacity is an important feature that allows the prepared hydrogel to perform the required application. Some disadvantages may arise such as the low mechanical properties that are suggested to be overcome. IPNs can be used in various applications that serve the human requirements like drug delivery, tissue engineering, medical and packaging applications. Hydrogels present biocompatibility and nontoxicity when used in biomedical applications. Interpenetrating hydrogels can be prepared from natural or synthetic polymers. Polysaccharides as natural polymers can be used to produce efficient interpenetrating hydrogels. Polyacrylates, poly(ethylene glycol) and poly(vinyl alcohol) are designated as promising synthetic polymers capable of forming interpenetrating hydrogels.

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“…The cytotoxicity investigation of MCF-7 cells by fluorescent live/dead cell assay and MTT assay suggests that folic acid-egg white/cyclophosphamide (IPN-NPs) displays higher toxicity compared to free cyclophosphamide and IPN-NPs. The attained folic acid-egg white/cyclophosphamide (IPN-NPs) might deliver a potential candidate for targeted breast cancer drug delivery [66].…”

Section: Nanoparticlesmentioning

confidence: 99%

Interpenetrating polymer network as a pioneer drug delivery system: a review

et al. 2019

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Interpenetrating polymer network (IPN) is an enterprising drug delivery system, comprising of two polymers with several advantages like stability, biocompatibility, high swelling capacity and biodegradability which plays an important function in targeted and controlled drug delivery. IPN acquired appreciable focus in the pharmaceutical sector mostly for the last few decades because of their utility in biomedical applications like tissue engineering and drug delivery at the target site at desired rate. For the past few years, different types of polymers obtained from natural or artificial sources have been used to prepare the IPN, resulting in improved properties; thus, IPN is considered in the category of the novel technologies demonstrating the superior performances as compared to the conventional technique. IPN development leads to the formation of dosage form with reduced side effects and prolonged drug action. The current topic includes IPN, types of IPN, mode of preparation, applications, delivery systems and list of polymers employed in the synthesis of IPN.

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Folic acid–egg white coated IPN network of carboxymethyl cellulose and egg white nanoparticles for treating breast cancer

Cited by 8 publications

References 39 publications

An insight on egg white: From most common functional food to biomaterial application

An insight on egg white: From most common functional food to biomaterial application

Interpenetrating polymeric hydrogels as favorable materials for hygienic applications

Interpenetrating polymer network as a pioneer drug delivery system: a review

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