Folic acid-conjugated glucose and dextran coated iron oxide nanoparticles as MRI contrast agents for diagnosis and treatment response of rheumatoid arthritis

Dai, Fengying; Du, Min; Liu, Yingguo; Liu, Guiying; Liu, Qingjun; Zhang, Xin

doi:10.1039/c3tb21732a

Cited by 42 publications

(28 citation statements)

References 34 publications

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“…Theranostic nanomedicine is intended to provide simultaneous diagnosis and treatment of a disease, with early detection, easy monitoring, targeted therapy and minimal toxicity. [146,147] Stable phosphocholine-functionalized SPIONs (18LPC/ SPIONs) have recently been prepared by exploiting hydrophobic interactions between a suitable phosphocholine (i.e., 1-octadecyl-2-hydroxy-sn-glycero-3-phosphocholine (18LPC) and an inner amphiphilic layer (oleic acid and oleylamine), covering the surface of the NPs. [145] Superparamagnetic iron oxide nanoparticles (SPIONs) are particularly attractive tools, being able to modify the transversal proton relaxation time (T2) of water molecules, thus resulting in effective contrast agents for in vivo magnetic resonance imaging (MRI) analyses.…”

Section: Interfacing Nucleolipidic Ru III Complexes With Bilayer-coatmentioning

confidence: 99%

Ru^III Complexes for Anticancer Therapy: The Importance of Being Nucleolipidic

et al. 2016

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Ruthenium complexes are attracting increasing attention as second‐generation metal‐based anticancer agents, with NAMI‐A and KP1019 as the major representatives of this class having undergone clinical trials. Our recent interest has been focused on the synthesis and characterization of new amphiphilic derivatives of nucleosides (nucleolipids). These compounds have been selected as core scaffolds linked to RuIII complexes and capable of self‐assembly into stable nanostructures in aq. solutions so to transport the metal ions efficiently into the cell. Through the use of ribo‐ and deoxyribonucleosides as starting building blocks, a mini‐library of nucleolipidic RuIII complexes decorated with diverse hydrophilic and lipophilic chains and incorporating the NAMI‐A analogue AziRu has been prepared. When co‐aggregated with biocompatible lipids, these RuIII‐containing nucleolipids proved to be stable for months under physiological conditions. Detailed microstructural characterization, carried out by a combined approach including different physico‐chemical techniques, allowed their stability, size and shape to be determined. Tested on a panel of human and non‐human cells, all of the studied RuIII complexes showed potent in vitro anticancer activity, significantly higher than that of NAMI‐A‐like analogues, and minimal toxicity. Here we summarize the design and synthetic procedures developed to prepare these new Ru‐containing candidate drugs, discussing the beneficial effects achievable through exploiting nucleolipid appendages in the delivery of metal‐based drugs.

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Section: Interfacing Nucleolipidic Ru III Complexes With Bilayer-coatmentioning

confidence: 99%

Ru^III Complexes for Anticancer Therapy: The Importance of Being Nucleolipidic

et al. 2016

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“…To increase the effectiveness of MNPs, improve their "stealthiness" and increase their blood circulation time to maximize the likelihood of reaching targeted tissues, several techniques including reducing size and grafting polymers have been used. For example, SPIONs with particle size below 9 nm show higher blood vessels penetration efficiency than larger NPs [45]. In addition, functionalization of MNPs with amino groups, silica, polymers, various surfactants or other organic compounds is usually performed in order to achieve better physical and chemical properties.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

“…Compared with conventional treatment, this magnetic targeted chemophotothermal treatment provided superior therapeutic efficacy with only 0.05% the dosage of MTX. In another study, Dai et al [45] coated SPION with Dex and glucose as MRI contrast agents to improve the stability of the MNPs during blood circulation. The balance between hydrodynamic diameter and superparamagnetic properties of the iron oxide colloid crystals were important parameters that were achieved by optimization of glucose content during the iron oxide crystal growth stage.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Recent approaches for targeted drug delivery in rheumatoid arthritis diagnosis and treatment

Chegini

Varshosaz

Taymouri

2018

Artificial Cells, Nanomedicine, and Biotechnology

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Rheumatoid arthritis (RA) is a chronic inflammatory disease with complex pathology characterized by inflammation of joints, devastation of the synovium, pannus formation, bones and cartilage destruction and often is associated with persistent arthritic pain, swelling, stiffness and work disability. In conventional RA therapy, because of short biological half-life, poor bioavailability, high and frequent dosing is required. Thereby, these anti-RA medications, which unable to selectively target affected zone, may cause severe side effects in extra-articular tissues. Today, nanotechnology has emerged as promising tool in the development of novel drug delivery systems for the treatment and diagnosis of intractable diseases such as RA. Active targeting in RA nanomedicine has also been introduced a successful way for facilitating specific uptake of therapeutic agents by the disease cells. In this review, it is attempted to describe various targeted drug delivery systems (localized and receptor-based) used for RA diagnosis and therapy. Then, we highlight recent developments related to various non-viral gene delivery systems for RA gene therapy.

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“…Folate could also be conjugated to generation five poly (amidoamide) (PAMAM) dendrimers loaded with MTX to treat inflammatory arthritis with comparable anti‐inflammatory effects to folate‐targeted MTX‐conjugated polymers . Aiming at the high expression of folate receptors on activated macrophages in RA, folic acid‐conjugated dextran and glucose‐coated iron oxide nanoparticles were developed as MRI contrast agents for diagnosis and evaluation of therapeutic effects …”

Section: Targeting Nms Relieve the Att Of Ramentioning

confidence: 99%

Move to Nano‐Arthrology: Targeted Stimuli‐Responsive Nanomedicines Combat Adaptive Treatment Tolerance (ATT) of Rheumatoid Arthritis

Liu

Guo

Liang

2018

Biotechnology Journal

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Rheumatoid arthritis (RA) is one of the most popular chronic autoimmune diseases characterized with persistent synovial inflammation and bone destruction. Although considerable developments have been gained in clinical treatment of RA, the major drawback to RA therapy stems from the adaptive treatment tolerance (ATT) following the long-term drug use, which causes compromised efficacy, sustained drug dose increase, and severe adverse events. To address these challenges, it is of great significance to put forward innovative therapeutic approaches for RA treatment. Nowadays, developments of nanotechnology-based nanomedicines (NMs) for RA are in progress. Multifunctional NMs with targeted stimuli-responsive features have been one of the central concepts in designing more accessible formulations for efficient RA treatment. These NMs are able to postpone RA progression effectively, because of their delivery and on-demand release of medicaments at targeted sites in response to external or internal stimuli related to the RA pathophysiology without obvious adverse side-effects on the normal tissues. Therefore, NMs have gained interest from pre-clinical research scientists as well as clinical doctors worldwide. Herein, the authors highlight the recent attempts of targeted stimuli-responsive NMs for RA therapy in the last 5 years. The described progresses may pave the way to novel and highly effective RA NMs.

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Folic acid-conjugated glucose and dextran coated iron oxide nanoparticles as MRI contrast agents for diagnosis and treatment response of rheumatoid arthritis

Abstract: Folic acid-conjugated glucose and dextran coated SPIO nanoparticles were used for the diagnosis and treatment response of rheumatoid arthritis.

Cited by 42 publications

References 34 publications

Ru^III Complexes for Anticancer Therapy: The Importance of Being Nucleolipidic

Ru^III Complexes for Anticancer Therapy: The Importance of Being Nucleolipidic

Recent approaches for targeted drug delivery in rheumatoid arthritis diagnosis and treatment

Move to Nano‐Arthrology: Targeted Stimuli‐Responsive Nanomedicines Combat Adaptive Treatment Tolerance (ATT) of Rheumatoid Arthritis

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Folic acid-conjugated glucose and dextran coated iron oxide nanoparticles as MRI contrast agents for diagnosis and treatment response of rheumatoid arthritis

Abstract: Folic acid-conjugated glucose and dextran coated SPIO nanoparticles were used for the diagnosis and treatment response of rheumatoid arthritis.

Cited by 42 publications

References 34 publications

RuIII Complexes for Anticancer Therapy: The Importance of Being Nucleolipidic

RuIII Complexes for Anticancer Therapy: The Importance of Being Nucleolipidic

Recent approaches for targeted drug delivery in rheumatoid arthritis diagnosis and treatment

Move to Nano‐Arthrology: Targeted Stimuli‐Responsive Nanomedicines Combat Adaptive Treatment Tolerance (ATT) of Rheumatoid Arthritis

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Ru^III Complexes for Anticancer Therapy: The Importance of Being Nucleolipidic

Ru^III Complexes for Anticancer Therapy: The Importance of Being Nucleolipidic