Folate-grafted boron nitride nanotubes: Possible exploitation in cancer therapy

Ferreira, Tiago Hilário; Marino, Attilio; Rocca, Antonella; Liakos, Ioannis; Nitti, Simone; Athanassiou, Athanassia; Mattoli, Virgilio; Mazzolai, Barbara; Sousa, Edésia Martins Barros de; Ciofani, Gianni

doi:10.1016/j.ijpharm.2015.01.048

Cited by 48 publications

(38 citation statements)

References 40 publications

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“…49 Additional potential applications of BNNPs include their utilization for boron neutron capture therapy, 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 where BNNPs could promote high boron concentration, 50,51 or as bionanotransducers for cell sensing and stimulation due to their specific piezoelectric properties. 52-54…”

Section: Discussionmentioning

confidence: 99%

Boron Nitride Nanoparticles with a Petal-Like Surface as Anticancer Drug-Delivery Systems

Сухорукова

Zhitnyak

Kovalskii

et al. 2015

ACS Appl. Mater. Interfaces

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Nanoparticles (NPs) have a great potential as nanosized drug-delivery carriers. Such systems must safely deliver the drug to the site of the tumor without drug leakage, effectively penetrate inside cancer cells, and provide intracellular drug release. Herein we developed an original and simple method aimed at the fabrication of spherical boron nitride NPs (BNNPs), 100-200 nm in diameter, with peculiar petal-like surfaces via chemical vapor deposition. Such structures were found to be able to absorb a large amount of antitumor drug-killing tumor cells. They revealed low cytotoxicity and rapid cellular uptake. BNNPs were saturated with doxorubicin (DOX) and then dispersed. The BNNPs loaded with DOX (BNNPs-DOX) were stable at neutral pH but effectively released DOX at pH 4.5-5.5. MTT assay and cell growth testing showed that the BNNPs-DOX nanocarriers had been toxic for IAR-6-1 cells. BNNPs loaded with DOX penetrated into the neoplastic IAR-6-1 cells using endocytic pathways, and then DOX released into the cytoplasm and cell nuclei and resulted in cell death.

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Section: Discussionmentioning

confidence: 99%

Boron Nitride Nanoparticles with a Petal-Like Surface as Anticancer Drug-Delivery Systems

Сухорукова

Zhitnyak

Kovalskii

et al. 2015

ACS Appl. Mater. Interfaces

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“…41 FA was covalently grafted on the surface of BNNS through esterification reaction according to a previously reported method. 40 Briefly, 10 mg of BNNS was first treated with HNO 3 (65%) and ultrasound for 1 hour, then subjected to stirring overnight at 70°C. Thus, hydroxyl groups were introduced on the surface of BNNS.…”

Section: Preparation Of Bnns-famentioning

confidence: 99%

“…29,30,42 The distinct peaks at 1,700 cm -1 assigned to the C=O amide stretching of FA molecule appeared in the spectrum of BNNS-FA complexes. 40 This result suggested that FA was grafted onto BNNS. UV-vis spectra of FA, BNNS, and BNNS-FA complexes are shown in Figure 3B.…”

Section: Dox Loading and Ph-dependent Releasementioning

confidence: 99%

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Folate-conjugated boron nitride nanospheres for targeted delivery of anticancer drug

Feng

Zhang

Yan

et al. 2016

IJN

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With its unique physical and chemical properties and structural similarity to carbon, boron nitride (BN) has attracted considerable attention and found many applications. Biomedical applications of BN have recently started to emerge, raising great hopes in drug and gene delivery. Here, we developed a targeted anticancer drug delivery system based on folate-conjugated BN nanospheres (BNNS) with receptor-mediated targeting. Folic acid (FA) was successfully grafted onto BNNS via esterification reaction. In vitro cytotoxicity assay showed that BNNS-FA complexes were non-toxic to HeLa cells up to a concentration of 100 μg/mL. Then, doxorubicin hydrochloride (DOX), a commonly used anticancer drug, was loaded onto BNNS-FA complexes. BNNS-FA/DOX complexes were stable at pH 7.4 but effectively released DOX at pH 5.0, which exhibited a pH sensitive and sustained release pattern. BNNS-FA/DOX complexes could be recognized and specifically internalized by HeLa cells via FA receptor-mediated endocytosis. BNNS-FA/DOX complexes exhibited greater cytotoxicity to HeLa cells than free DOX and BNNS/DOX complexes due to the increased cellular uptake of DOX mediated by the FA receptor. Therefore, BNNS-FA complexes had strong potential for targeted cancer therapy.

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“…In order to form a hybrid system that includes the characteristics of both materials, it was proposed in this work the addition of BNNTs into a nPCL matrix. Taking advantage of the detectable signal through fluorescence microscope coming from BNNTs [21], it may be possible to modulate their emission in response to the adsorption of specific biomolecules, as already shown for carbon nanotubes [22] [23]. Thereby, it can be possible to develop a biosensor based on this hybrid system.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Characterization and Cell Adhesion Evaluation of Poly-ε-Caprolactone/BNNT Nanofibers Produced through Electrospinning Process

2017

International Journal of Advanced Research in Chemical Science

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Folate-grafted boron nitride nanotubes: Possible exploitation in cancer therapy

Cited by 48 publications

References 40 publications

Boron Nitride Nanoparticles with a Petal-Like Surface as Anticancer Drug-Delivery Systems

Boron Nitride Nanoparticles with a Petal-Like Surface as Anticancer Drug-Delivery Systems

Folate-conjugated boron nitride nanospheres for targeted delivery of anticancer drug

Physicochemical Characterization and Cell Adhesion Evaluation of Poly-ε-Caprolactone/BNNT Nanofibers Produced through Electrospinning Process

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