Boron Nitride Nanoparticles with a Petal-Like Surface as Anticancer Drug-Delivery Systems

Abstract

Nanoparticles (NPs) have a great potential as nanosized drug-delivery carriers. Such systems must safely deliver the drug to the site of the tumor without drug leakage, effectively penetrate inside cancer cells, and provide intracellular drug release. Herein we developed an original and simple method aimed at the fabrication of spherical boron nitride NPs (BNNPs), 100-200 nm in diameter, with peculiar petal-like surfaces via chemical vapor deposition. Such structures were found to be able to absorb a large amount of antitumor drug-killing tumor cells. They revealed low cytotoxicity and rapid cellular uptake. BNNPs were saturated with doxorubicin (DOX) and then dispersed. The BNNPs loaded with DOX (BNNPs-DOX) were stable at neutral pH but effectively released DOX at pH 4.5-5.5. MTT assay and cell growth testing showed that the BNNPs-DOX nanocarriers had been toxic for IAR-6-1 cells. BNNPs loaded with DOX penetrated into the neoplastic IAR-6-1 cells using endocytic pathways, and then DOX released into the cytoplasm and cell nuclei and resulted in cell death.

Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology

“…Meanwhile, the application of bismuth NPs will be presented here. Although there is not a lot of data about the application of other metalloid NPs in medicine in cancer research in particular, to the best of the authors' knowledge, boron NPs have been used for different diagnosis or therapeutic purposes in cancer models [160,161], but other metalloid NPs such as germanium are frequently used in other areas of nanotechnology. Silicon NPs are also well-known as quantum dot (QD) agents and typically used for diagnostic systems [162].…”

The study of new anticancer drug delivery system based on the boron nitride nanoparticles

“…Наночастицы гексагональ-ного нитрида бора размером 100-150 нм были полу-чены методом химического осаждения из газовой фазы (I. V. Sukhorukovа и соавт. [25] Морфология поверхности наночастиц нитрида бора зависела от скоростей подачи транспортного (Ar) и ре-акционного (NH 3 ) газов. Для синтеза наночастиц с глад-кой наружной поверхностью скорости потока для Ar и NH 3 составляли 500 и 100 см 3 /мин соответственно, а для синтеза наночастиц с развитой наружной по-верхностью -250 и 50 см 3 /мин.…”

“…7). Ранее мы также показали, что ингибитор динаминопосредованного эндоцитоза динасор угнета-ет накопление доксорубицина в клетках, инкубирован-ных с частицами нитрида бора, нагруженными доксору-бицином [25]. Полученные данные указывают на то, что наноконъюгаты нитрида бора с доксорубицином высвобождают химиопрепарат вне зоны мембранных транспортеров и поэтому могут рассматриваться в пла-не их возможного применения для преодоления меха-низмов множественной лекарственной устойчивости.…”

Plasma Surface Polymerized and Biomarker Conjugated Boron Nitride Nanoparticles for Cancer-Specific Therapy: Experimental and Theoretical Study

“…Due to high chemical stability [21], different inorganic NPs, such as mesoporous silica [22], iron oxide [23], hexagonal boron nitride (h-BN) [24], and carbon nanotubes [25], have been developed and tested in NP-based cancer therapy. Among them, h-BN nanoparticles (BNNPs) are of particular interest due to their excellent biocompatibility [26], high drug loading capacity [27], and therapeutic efficacy toward tumor cells with multiple drug resistance [28].…”