Physicochemical Characterization and Cell Adhesion Evaluation of Poly-ε-Caprolactone/BNNT Nanofibers Produced through Electrospinning Process

doi:10.20431/2349-0403.0410004

Cited by 1 publication

(1 citation statement)

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“…The plasma treatment had changed the hydrophobic BNNT film in to a more hydrophilic surface, which was attributed to be the cause for the increased cell number on the film [81]. In another study, MRC-5 human lung fibroblast cells, exhibited good adhesion on PCL-BNNTs nanofibers that were comparable to the cell adhesion observed on pristine PCL nanofibers [82]. Though the mechanism contributing to the cell adhesion was not investigated in the study, it is likely to be influenced by the surface topography of the nanofibrous scaffold.…”

Section: Bnnts and Cell Adhesionmentioning

confidence: 97%

Boron nitride nanotube scaffolds: emergence of a new era in regenerative medicine

Anandhan

Krishnan

2021

Biomed. Mater.

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Tissue engineering scaffolds have transformed from passive geometrical supports for cell adhesion, extension and proliferation to active, dynamic systems that can in addition, trigger functional maturation of the cells in response to external stimuli. Such ‘smart’ scaffolds require the incorporation of active response elements that can respond to internal or external stimuli. One of the key elements that direct the cell fate processes is mechanical stress. Different cells respond to various types and magnitudes of mechanical stresses. The incorporation of a pressure-sensitive element in the tissue engineering scaffold therefore, will aid in tuning the cell response to the desired levels. Boron nitride nanotubes (BNNTs) are analogous to carbon nanotubes and have attracted considerable attention due to their unique amalgamation of chemical inertness, piezoelectric property, biocompatibility and, thermal and mechanical stability. Incorporation of BNNTs in scaffolds confers them with piezoelectric property that can be used to stimulate the cells seeded on them. Biorecognition and solubilization of BNNTs can be engineered through surface functionalization with different biomolecules. Over the years, the importance of BNNT has grown in the realm of healthcare nanotechnology. This review discusses the salient properties of BNNTs, the influence of functionalization on their in vitro and in vivo biocompatibility, and the uniqueness of BNNT-incorporated tissue engineering scaffolds.

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Section: Bnnts and Cell Adhesionmentioning

confidence: 97%