Folate distribution in barley (Hordeum vulgare L.), common wheat (Triticum aestivum L.) and durum wheat (Triticum turgidum durum Desf.) pearled fractions

Giordano, Debora; Reyneri, Amedeo; Blandino, Massimo

doi:10.1002/jsfa.7276

Cited by 26 publications

(13 citation statements)

References 39 publications

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“…As a result, malignant cells are unable to synthesize DNA and RNA, leading to cell apoptosis (35). This confirms the findings of previous studies emphasizing the crucial role of folates in root development (36,37). Cantharidin is a natural substance, secreted by blister beetles, particularly Lytta vesicatoria , which inhibits protein phosphatase 2A.…”

Section: Discussionsupporting

confidence: 92%

Predictive power of the Triticum root elongation test for the assessment of novel anti‑proliferative therapies

et al. 2019

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The use of alternative techniques to reduce the number of animals used in anticancer research is an issue of current interest. The aim of this study was to validate the use of a simple and efficient alternative tool for the assessment of the potential of novel anti-proliferative agents. A set of 20 compounds with various mechanisms were tested in the Triticum aestivum root elongation assay, using aminophyl-line as negative control. Hierarchical cluster analyses were performed using the furthest neighbor method based on Euclidean distance measure, and the compounds were statistically analyzed in reference to their anti-proliferative pattern registered in the NCI60 human tumor cell line anticancer drug screen. A correlation between the Triticum test results and the NCI60 anti-proliferative profile was made for a number of human cells that we defined as the Triticum cell panel. Linear equations were computed that can be used to transform the inhibitory effect measured in any future Triticum assay in order to predict the effect on particular human cells. Of the tested anti-proliferative agents, methotrexate, colchicine, cantharidin, cisplatin and verapamil produced a growth inhibition over 50%. On the whole, the findings of this study suggest that the Triticum test can be used to detect several types of anti-proliferative mechanisms, particularly those targeting tubulin, rendering it a useful tool with which to identify novel mitotic spindle inhibitors.

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Section: Discussionsupporting

confidence: 92%

Predictive power of the Triticum root elongation test for the assessment of novel anti‑proliferative therapies

et al. 2019

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“…Green malt has the highest functional ingredients including antioxidant activity (79.80%), total phenolic (122.43 mg/100 g), (+)-catechin (69.06 mg/100 g), quercetin (30.78 mg/100 g), 1,2-dihydroxybenzene (37.21 mg/100 g), isorhamnetin (22.44 mg/100 g), and carotenoid (0.171 mg/100 g) [22]. The germ and the outer layers of hulless barley grains have the highest folate concentration (103.3 mg/100 g) [23]. The average concentrations of K, Ca, and Fe in barley grass powder were 6.7, 12.0, and 4.6 times that of barley grains, especially the qK1/qMg1/qCa1 region with large additive effects in Bmag0211~GBMS0014 on chromosome 1H [24].…”

Section: Functional Ingredients In Barleymentioning

confidence: 99%

“…The GABA has a very important role in mediating NaCl stress phenolic compounds accumulation in germinated hulless barley [38]. Linoleic acid content increased from 51.74% to 56.56% and oil from 1.73 to 2.13%, while oleic content decreased from 19.94% to 15.62% and palmitic acid from 18.53% to 17.33% during barley malting process [23].…”

Section: Tocolsmentioning

confidence: 99%

Molecular Mechanism of Functional Ingredients in Barley to Combat Human Chronic Diseases

Zeng

et al. 2020

Oxidative Medicine and Cellular Longevity

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Barley plays an important role in health and civilization of human migration from Africa to Asia, later to Eurasia. We demonstrated the systematic mechanism of functional ingredients in barley to combat chronic diseases, based on PubMed, CNKI, and ISI Web of Science databases from 2004 to 2020. Barley and its extracts are rich in 30 ingredients to combat more than 20 chronic diseases, which include the 14 similar and 9 different chronic diseases between grains and grass, due to the major molecular mechanism of six functional ingredients of barley grass (GABA, flavonoids, SOD, K-Ca, vitamins, and tryptophan) and grains (β-glucans, polyphenols, arabinoxylan, phytosterols, tocols, and resistant starch). The antioxidant activity of barley grass and grain has the same and different functional components. These results support findings that barley grain and its grass are the best functional food, promoting ancient Babylonian and Egyptian civilizations, and further show the depending functional ingredients for diet from Pliocene hominids in Africa and Neanderthals in Europe to modern humans in the world. This review paper not only reveals the formation and action mechanism of barley diet overcoming human chronic diseases, but also provides scientific basis for the development of health products and drugs for the prevention and treatment of human chronic diseases.

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“…8 (Pioneer 3245, 2011 growing season). The total folate content was determined through a microbiological assay according to the AOAC Method 2004.05 (DeVries et al, 2005, with a few modifications, as reported by Giordano et al (2016a). The amount of folate in each sample was determined through a comparison with calibration curves of folic acid (Sigma-Aldrich, Saint Luis, Missouri).…”

Section: Analysis Of the Total Folate Contentmentioning

confidence: 99%

Distribution of bioactive compounds in maize fractions obtained in two different types of large scale milling processes

Blandino

Alfieri

Giordano

et al. 2017

Journal of Cereal Science

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Maize kernels contain different bioactive compounds that are important for human 1 health. The aim of this study was to analyze the distribution of the bioactive 2 compounds in maize fractions derived from two industrial dry-milling processes, 3 characterized by a dry-degermination (DD) system and a tempering-degermination 4 (TD) system. 5The bioactive compounds in maize resulted unevenly distributed in the milling 6 fractions of the kernel. By-products such as the germ and the animal feed flour, had 7 higher total antioxidant capacity (TAC), total polyphenol content (TPC) and total

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Folate distribution in barley (Hordeum vulgare L.), common wheat (Triticum aestivum L.) and durum wheat (Triticum turgidum durum Desf.) pearled fractions

Cited by 26 publications

References 39 publications

Predictive power of the Triticum root elongation test for the assessment of novel anti‑proliferative therapies

Predictive power of the Triticum root elongation test for the assessment of novel anti‑proliferative therapies

Molecular Mechanism of Functional Ingredients in Barley to Combat Human Chronic Diseases

Distribution of bioactive compounds in maize fractions obtained in two different types of large scale milling processes

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